(1 reference)-
- 抗原 See all LKB1 (STK11) 抗体
- LKB1 (STK11) (serine/threonine Kinase 11 (STK11))
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适用
- 人
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This LKB1 antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
- 特异性
- This antibody detects endogenous levels of LKB1 protein. (region surrounding Gln434)
- 交叉反应 （详细）
- Species reactivity (tested):Human.
- 纯化方法
- Affinity chromatography
- 纯度
- > 95 % by SDS-PAGE
- Top Product
- Discover our top product STK11 Primary Antibody
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anti-serine/threonine Kinase 11 (STK11) (AA 134-433) antibody
STK11 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-serine/threonine Kinase 11 (STK11) antibodySTK11 适用: 人, 小鼠, 大鼠 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-serine/threonine Kinase 11 (STK11) (AA 14-44), (N-Term) antibodySTK11 适用: 人 WB, IF, IHC (p), FACS 宿主: 兔 Polyclonal RB3547 unconjugated
anti-serine/threonine Kinase 11 (STK11) (AA 14-44) antibodySTK11 适用: 人 WB, ELISA, IHC, IF, FACS 宿主: 兔 Polyclonal unconjugated
anti-serine/threonine Kinase 11 (STK11) (pSer428) antibodySTK11 适用: 人, 小鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-serine/threonine Kinase 11 (STK11) (AA 19-48) antibodySTK11 适用: 人 WB, ELISA, IF, FACS 宿主: 兔 Polyclonal unconjugated
anti-serine/threonine Kinase 11 (STK11) (Tyr1313) antibodySTK11 适用: 人, 小鼠 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-serine/threonine Kinase 11 (STK11) (AA 1-433) antibodySTK11 适用: 人 WB, IF, PLA 宿主: 兔 Polyclonal unconjugated
anti-serine/threonine Kinase 11 (STK11) (Internal Region) antibodySTK11 适用: 人, 小鼠, 大鼠 WB, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-serine/threonine Kinase 11 (STK11) (pThr189) antibodySTK11 适用: 人, 小鼠 WB, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
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- 应用备注
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Western Blot: 1/500 - 1/1000. Immunohistochemistry: 1/50 - 1/200.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. - 限制
- 仅限研究用
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- 浓度
- 1,0 mg/mL
- 缓冲液
- Phosphate buffered saline (PBS), pH 7.2., 0.05 % sodium azide
- 储存液
- Sodium azide
- 注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 注意事项
- Avoid repeated freezing and thawing.
- 储存条件
- 4 °C/-20 °C
- 储存方法
- Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
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: "Repositioning of Somatic Golgi Apparatus Is Essential for the Dendritic Establishment of Adult-Born Hippocampal Neurons." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 38, Issue 3, pp. 631-647, (2019) (PubMed).
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: "Repositioning of Somatic Golgi Apparatus Is Essential for the Dendritic Establishment of Adult-Born Hippocampal Neurons." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 38, Issue 3, pp. 631-647, (2019) (PubMed).
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- 抗原
- LKB1 (STK11) (serine/threonine Kinase 11 (STK11))
- 别名
- STK11 (STK11 产品)
- 别名
- pjs antibody, LKB1 antibody, XEEK1 antibody, Stk11 antibody, PJS antibody, hLKB1 antibody, AA408040 antibody, Lkb1 antibody, Par-4 antibody, R75140 antibody, mLKB1 antibody, wu:fj61a05 antibody, zgc:110180 antibody, xeek1 antibody, serine/threonine kinase 11 antibody, polarization-related protein LKB1 antibody, serine/threonine kinase 11 L homeolog antibody, STK11 antibody, stk11 antibody, LOC662493 antibody, Stk11 antibody, stk11.L antibody
- 背景
- LKB1, a member of the serine/threonine kinase family, is a tumor suppressor. Physically associates with p53, it regulates specific p53 dependent apoptosis pathways. LKB1 protein is present in both the cytoplasm and nucleus of living cells and translocates to mitochondria during apoptosis. Restoring LKB1 activity into cancer cell lines defective for its expression results in a G1 cell cycle arrest.Mutations in LKB1 gene are associated with Peutz Jeghers syndrome, an autosomal dominant disorder characterized by the growth of polyps in the gastrointestinal tract, pigmented macules on the skin and mouth, and other neoplasms. LKB1 functions as a master upstream protein kinase, regulating AMPK related kinases as well as AMPK. In vitro, LKB1 has been observed to directly phosphorylate threonine 172 of AMPKa, an event that is correlated with activation of this kinase. LKB1 has also been found to play a role in chromatin remodeling, cell cycle arrest, Wnt signaling, cell polarity, and energy metabolism.Synonyms: LKB1, NY-REN-19, PJS, Renal carcinoma antigen NY-REN-19, Serine/threonine-protein kinase 11, Serine/threonine-protein kinase LKB1
- 分子量
- approx. 54 kDa
- 基因ID
- 6794
- NCBI登录号
- NP_000446
- UniProt
- Q15831
- 途径
- AMPK Signaling, Carbohydrate Homeostasis, Regulation of Carbohydrate Metabolic Process, Warburg Effect
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