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Tuberin 抗体 (pSer1254)
TSC2
适用: 人
IHC (p)
宿主: 兔
Polyclonal
unconjugated
Tuberin抗体详情
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抗原
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Tuberin (TSC2)
(Tuberous Sclerosis 2 (TSC2))
抗原表位
All epitopes for Tuberin 抗体
pSer1254
适用
All reactivities for Tuberin 抗体
人
宿主
All hosts for Tuberin 抗体
兔
克隆类型
All clonalities for Tuberin 抗体
多克隆
标记
All conjugates for Tuberin 抗体
This Tuberin antibody is un-conjugated
应用范围
All applications for Tuberin 抗体
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
特异性
This antibody detects endogenous levels of p-Tsc2 protein only when phosphorylated at Ser1254.
交叉反应 (详细)
Species reactivity (tested):Human.
纯化方法
Affinity chromatography
纯度
> 95 % by SDS-PAGE
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使用细节
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应用备注
Immunohistochemistry: 1/50 - 1/200. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
限制
仅限研究用
贮存及处理
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浓度
1,0 mg/mL
缓冲液
Phosphate buffered saline (PBS), pH 7.2., 0.05 % sodium azide
储存液
Sodium azide
注意事项
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
注意事项
Avoid repeated freezing and thawing.
储存条件
4 °C/-20 °C
储存方法
Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Tuberin目标详情
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抗原
Tuberin (TSC2)
(Tuberous Sclerosis 2 (TSC2))
别名
Tuberin / TSC2 (TSC2 产品 )
别名
TSC2 antibody, fc16b02 antibody, tuberin antibody, wu:fc16b02 antibody, LAM antibody, TSC4 antibody, Nafld antibody, Tcs2 antibody, Rc antibody, TSC complex subunit 2 antibody, tuberin antibody, hypothetical protein antibody, tuberous sclerosis 2 antibody, TSC2 antibody, LOC5569538 antibody, tsc2 antibody, PGTG_00159 antibody, Tsc2 antibody
背景
Tuberin, or TSC2 (Tuberous sclerosis complex), is implicated as a tumor suppressor. It may function in vesicular transport, and may also play a role in the regulation of cell growth arrest and in the regulation of transcription mediated by steroid receptors. Interaction between hamartin (TSC1) and tuberin may facilitate vesicular docking. It specifically stimulates the intrinsic GTPase activity of the Ras related protein RAP1A and RAB5, suggesting a possible mechanism for its role in regulating cellular growth. Mutations in tuberin lead to constitutive activation of RAP1A in tumors. At least three isoforms of Tuberin exist.Synonyms: TSC4, Tuberous sclerosis 2 protein
分子量
approx. 200 kDa
基因ID
7249
NCBI登录号
NP_000539
UniProt
P49815
途径
RTK signaling , AMPK Signaling , Fc-epsilon Receptor Signaling Pathway , EGFR Signaling Pathway , Neurotrophin Signaling Pathway , Regulation of Cell Size , Tube Formation , Protein targeting to Nucleus
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