CHEK1 抗体
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北京 101111
Quick Overview for CHEK1 抗体 (ABIN3209997)
抗原
See all CHEK1 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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交叉反应
- 小鼠
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纯化方法
- Purified antibody.
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免疫原
- CHK1 antibody was raised in Mouse using a purified recombinant fragment of CHK1 expressed in E. coli as the immunogen.
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亚型
- IgG1
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应用备注
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ELISA: 1:10,000, WB: 1:500-1:2,000
Optimal conditions should be determined by the investigator. -
限制
- 仅限研究用
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浓度
- Lot specific
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缓冲液
- Purified antibody supplied in PBS containing 0.03 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium Azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
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注意事项
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Avoid repeated freeze/thaw cycles.
Dilute only prior to immediate use. -
储存条件
- 4 °C/-20 °C
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储存方法
- Store at 4 °C for short term storage. Store at -20 °C for long term storage.
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- CHEK1 (Checkpoint Kinase 1 (CHEK1))
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别名
- CHK1
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背景
- CHK1 is a kinase that phosphorylates Cdc25, an important phosphatase in cell cycle control, particularly for entry into mitosis. Cdc25, when phosphorylated on serine 216 by chk1 becomes bound by an adaptor protein in the cytoplasm. Therefore it is inhibited from removing the inhibiting phosphate from MPF (mitotic/maturation promoting factor) added by Wee1. Consequently, a cell is prevented from entering mitosis. Synonyms: Monoclonal CHK1 antibody, Anti-CHK1 antibody, CHK-1 antibody, CHK 1 antibody, CHEK1 antibody.
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途径
- p53 Pathway, Apoptosis, Cell Division Cycle, DNA Damage Repair
抗原
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