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FAS 抗体 (Extracellular Domain)

Name: FAS 抗体 (Extracellular Domain)
SKU: ABIN319859
Availability: OutOfStock

FAS 适用: 人, 猴 FACS, IP 宿主: 小鼠 Monoclonal LOB 3-17 unconjugated

产品编号 ABIN319859

发货至: 中国

Datasheet as PDF

抗原 See all FAS 抗体

FAS (TNF Receptor Superfamily, Member 6 (FAS))
抗原表位
25

16

16

8

7

6

5

4

4

4

4

4

3

3

3

3

3

2

2

2

2

2

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1
Extracellular Domain
适用
207

66

62

18

6

4

2

2

1

1
人, 猴
宿主
156

85

4

2

1

1

1
小鼠
Compatible Secondaries
克隆类型
156

92

1
单克隆
标记
115

27

25

12

11

7

4

4

3

3

3

3

3

3

3

3

3

2

2

2

2

1

1

1

1

1

1

1

1

1

1
This FAS antibody is un-conjugated
应用范围
160

112

73

64

34

33

27

26

26

18

16

9

8

6

5

4

4

2

2

2

2

1

1
Flow Cytometry (FACS), Immunoprecipitation (IP)

特异性

This antibody recognises the CD95 cell surface antigen.

纯化方法

Affinity Chromatography on Protein A.

免疫原

Fusion protein comprising extracellular domain of human Fas linked to human Fc. Spleen cells from immunised BALB/c mice were fused with cells of the mouse NSI myeloma cell line.

克隆位点

LOB 3-17

亚型

IgG1

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应用备注

Flow Cytometry: Use 10 μL of 1/50-1/100 diluted antibody to label 10^6 cells in 100 μL. Immunoprecipitation: 20 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

限制

仅限研究用
浓度

1.0 mg/mL

缓冲液

Tris NaCl, pH 8.0 containing 0.09 % Sodium Azide as preservative.

储存液

Sodium azide

注意事项

This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

注意事项

Avoid repeated freezing and thawing.

储存条件

4 °C/-20 °C

储存方法

Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
抗原

FAS (TNF Receptor Superfamily, Member 6 (FAS))

别名

CD95 / FAS (FAS 产品)

别名

ALPS1A antibody, APO-1 antibody, APT1 antibody, CD95 antibody, FAS1 antibody, FASTM antibody, TNFRSF6 antibody, AI196731 antibody, APO1 antibody, TNFR6 antibody, Tnfrsf6 antibody, lpr antibody, Fas cell surface death receptor antibody, Fas (TNF receptor superfamily member 6) antibody, FAS antibody, Fas antibody, fas antibody

背景

CD95, also known as FAS or APO1, is a 36 kDa cell surface type I membrane glycoprotein with an apparent molecular weight of 44 kDa on SDS PAGE. CD95 is a member of the TNF receptor family, which includes TNFR1, TNFR2, CD27, CD30 and CD40. Binding of CD95 Ligand to CD95 or crosslinking of CD95 by anti CD95 monoclonal antibodies leads to apoptosis of CD95 expressing cells. CD95 belongs to a subgroup of family members that have a death domain (DD) which contains 70 amino acids near the carboxyl terminal region of the molecule. The binding of adaptor molecules to this DD is responsible for transmitting the death signal for apoptosis. Stimulation of CD95 results in aggregation of its DD, leading to the recruitment of FADD and caspase 8 that together with the receptor form the death inducing signaling complex (DISC). CD95/CD95L is involved in the peripheral deletion of activated mature T cells at the end of the immune response and defects in this pathway predispose to autoimmune disorders. CD95 is also involved in killing of targets such as virus infected cells or cancer cells and killing of inflammatory cells at immune privileged sites. CD95 is expressed by activated T and B cells, NK cells and thymocytes.Synonyms: APT1, Apo-1 antigen, FAS1, FASLG receptor, TNFRSF6, Tumor necrosis factor receptor superfamily member 6

基因ID

355

NCBI登录号

NP_000034

UniProt

P25445

途径

p53 Pathway, Apoptosis, Production of Molecular Mediator of Immune Response, Positive Regulation of Endopeptidase Activity