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IL1R2 抗体

IL1R2 适用: 人 WB, IF, IHC (p), EIA, IP 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN303103
发货至: 中国
  • 抗原 See all IL1R2 抗体
    IL1R2 (Interleukin 1 Receptor, Type II (IL1R2))
    适用
    • 71
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    宿主
    • 50
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    克隆类型
    • 52
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    多克隆
    标记
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    This IL1R2 antibody is un-conjugated
    应用范围
    • 61
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    Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA), Immunoprecipitation (IP)
    交叉反应 (详细)
    Species reactivity (tested):Human.
    纯化方法
    Protein A Chromatography.
    免疫原
    Recombinant Human IL-1R type II.
    Top Product
    Discover our top product IL1R2 Primary Antibody
  • 应用备注
    Immunohistochemistry on Paraffin Sections (10 μg/mL). Western Blot. Immunofluorescence. Immunoprecipitation. ELISA.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    限制
    仅限研究用
  • 浓度
    2.0 mg/mL
    缓冲液
    0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2 with 0.01 % (w/v) Sodium Azide as preserevative.
    储存液
    Sodium azide
    注意事项
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    注意事项
    Avoid repeated freezing and thawing.
    储存条件
    4 °C/-20 °C
    储存方法
    Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.
  • 抗原
    IL1R2 (Interleukin 1 Receptor, Type II (IL1R2))
    别名
    CD121b / IL1R2 (IL1R2 产品)
    别名
    CD121b antibody, CDw121b antibody, IL-1R-2 antibody, IL-1RT-2 antibody, IL-1RT2 antibody, IL1R2c antibody, IL1RB antibody, Il1r-2 antibody, IL-1R2 antibody, interleukin 1 receptor type 2 antibody, interleukin 1 receptor, type II antibody, interleukin-like antibody, IL1R2 antibody, Il1r2 antibody, KK34 antibody
    背景
    CDw121b is a 65 kD member of the immunoglobulin superfamily also known as IL-1 receptor (IL-1R) type II. The IL-1R family is composed of three proteins: IL-1R type I, IL-1R type II, and the widely expressed IL-1R AcP. Both IL-1R type I and type II bind IL-1 alpha and IL-1 beta, although with differing affinities. The high affinity complex consists of IL-1R type I and IL-1R AcP, whereas IL-1 binds to IL-1R type II with low affinity. The IL-1 receptor antagonist (IL-1RA) can bind to both IL-1R type I and II. IL-1R type II is expressed at low levels on B cells, monocytes/macrophages, neutrophils, basal epithelia of the skin, and T cells. Binding of IL-1 to the high affinity IL-1 receptor mediates thymocyte and T cell activation, fibroblast proliferation, and induction of acute phase protein production. Binding of IL-1 to CDw121b appears to be dispensable for IL-1 signaling and may negatively regulate IL-1 responses acting as a quotdecoy quot receptor.Synonyms: CD121 antigen-like family member B, CDw121b, IL-1R-2, IL-1R-beta, IL1RB, Interleukin-1 receptor type II
    基因ID
    9606
    UniProt
    P27930
    途径
    NF-kappaB Signaling
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