ERCC2 抗体 (N-Term)
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- 抗原 See all ERCC2 抗体
- ERCC2 (Excision Repair Cross-Complementing Rodent Repair Deficiency, Complementation Group 2 (ERCC2))
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抗原表位
- N-Term
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适用
- 人, 小鼠, 大鼠, 豚鼠, Cow, 斑马鱼
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This ERCC2 antibody is un-conjugated
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应用范围
- Western Blotting (WB)
- 序列
- KLNVDGLLVY FPYDYIYPEQ FSYMRELKRT LDAKGHGVLE MPSGTGKTVS
- 交叉反应
- 牛, Fruit Fly (Drosophila melanogaster), 人, 小鼠, 猪, 大鼠
- 预测反应
- Cow: 100%, Guinea Pig: 100%, Human: 100%, Mouse: 100%, Rat: 100%, Zebrafish: 100%
- 产品特性
- This is a rabbit polyclonal antibody against ERCC2. It was validated on Western Blot using a cell lysate as a positive control.
- 纯化方法
- Affinity Purified
- 免疫原
- The immunogen is a synthetic peptide directed towards the N terminal region of human ERCC2
- Top Product
- Discover our top product ERCC2 Primary Antibody
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- 应用备注
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WB Suggested Anti-ERCC2 Antibody Titration: 0.2-1 µg/mL
ELISA Titer: 1:312500
Positive Control: Human Muscle.
Optimal working dilutions should be determined experimentally by the investigator. - 说明
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Antigen size: 760 AA
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- Lot specific
- 缓冲液
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 注意事项
- Avoid repeated freeze-thaw cycles.
- 储存条件
- -20 °C
- 储存方法
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- 抗原
- ERCC2 (Excision Repair Cross-Complementing Rodent Repair Deficiency, Complementation Group 2 (ERCC2))
- 别名
- ERCC2 (ERCC2 产品)
- 别名
- COFS2 antibody, EM9 antibody, TTD antibody, XPD antibody, AA407812 antibody, AU020867 antibody, AW240756 antibody, CXPD antibody, Ercc-2 antibody, MGC89573 antibody, CG9433 antibody, DhR3 antibody, DhXPD antibody, DmXPD antibody, Dmel\\CG9433 antibody, ERCC2 antibody, XPD/ERCC2 antibody, l(2)SH2 2137 antibody, l(2)SH2137 antibody, xpd antibody, zgc:56365 antibody, ERCC excision repair 2, TFIIH core complex helicase subunit antibody, excision repair cross-complementing rodent repair deficiency, complementation group 2 antibody, excision repair cross-complementation group 2 antibody, Xeroderma pigmentosum D antibody, ERCC2 antibody, Ercc2 antibody, ercc2 antibody, Xpd antibody
- 背景
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The nucleotide excision repair pathway is a mechanism to repair damage to DNA. ERCC2 is involved in transcription-coupled nucleotide excision repair and is an integral member of the basal transcription factor BTF2/TFIIH complex. This protein has ATP-dependent DNA helicase activity and belongs to the RAD3/XPD subfamily of helicases. Defects in this gene can result in three different disorders, the cancer-prone syndrome xeroderma pigmentosum complementation group D, trichothiodystrophy, and Cockayne syndrome. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. The nucleotide excision repair pathway is a mechanism to repair damage to DNA. The protein encoded by this gene is involved in transcription-coupled nucleotide excision repair and is an integral member of the basal transcription factor BTF2/TFIIH complex. The gene product has ATP-dependent DNA helicase activity and belongs to the RAD3/XPD subfamily of helicases. Defects in this gene can result in three different disorders, the cancer-prone syndrome xeroderma pigmentosum complementation group D, trichothiodystrophy, and Cockayne syndrome. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: COFS2, EM9, MGC102762, MGC126218, MGC126219, TTD, XPD
Protein Interaction Partner: GTF2H2C_2, UBC, FAM96B, CIAO1, rev, CDK7, TP53, MMS19, ERCC3, UVSSA, RAD52, GTF2H1, MNAT1, CCNH, GTF2F1, PIDD1, GTF2H3, GTF2H2, AR, ERCC6, tat, ATF7IP, HERC5, ISG15, TRIM25, RAD51, ERCC5, ERCC2, CDK1,
Protein Size: 760 - 分子量
- 87 kDa
- 基因ID
- 2068
- NCBI登录号
- NM_000400, NP_000391
- UniProt
- P18074
- 途径
- DNA Damage Repair
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