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- 抗原 See all ERCC2 抗体
- ERCC2 (Excision Repair Cross-Complementing Rodent Repair Deficiency, Complementation Group 2 (ERCC2))
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抗原表位
- C-Term
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适用
- 人, 小鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This ERCC2 antibody is un-conjugated
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应用范围
- Western Blotting (WB), ELISA
- 特异性
- ERCC2 Antibody detects endogenous levels of total ERCC2.
- 预测反应
- Pig,Zebrafish,Bovine,Sheep,Rabbit,Xenopus
- 纯化方法
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
- 免疫原
- A synthesized peptide derived from human ERCC2, corresponding to a region within C-terminal amino acids.
- 亚型
- IgG
- Top Product
- Discover our top product ERCC2 Primary Antibody
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anti-Excision Repair Cross-Complementing Rodent Repair Deficiency, Complementation Group 2 (ERCC2) antibody
ERCC2 适用: 人 WB, IHC 宿主: 兔 Monoclonal unconjugated
anti-Excision Repair Cross-Complementing Rodent Repair Deficiency, Complementation Group 2 (ERCC2) (Internal Region) antibodyERCC2 适用: 人, 小鼠 WB, IF, ICC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Excision Repair Cross-Complementing Rodent Repair Deficiency, Complementation Group 2 (ERCC2) (AA 1-300) antibodyERCC2 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Excision Repair Cross-Complementing Rodent Repair Deficiency, Complementation Group 2 (ERCC2) (AA 1-405) antibodyERCC2 适用: 人 WB, ELISA, IF 宿主: 小鼠 Monoclonal S3 unconjugated
anti-Excision Repair Cross-Complementing Rodent Repair Deficiency, Complementation Group 2 (ERCC2) (AA 1-300) antibodyERCC2 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Excision Repair Cross-Complementing Rodent Repair Deficiency, Complementation Group 2 (ERCC2) (AA 1-760) antibodyERCC2 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Excision Repair Cross-Complementing Rodent Repair Deficiency, Complementation Group 2 (ERCC2) (AA 1-760) antibodyERCC2 适用: 人 WB, IF 宿主: 小鼠 Polyclonal unconjugated
anti-Excision Repair Cross-Complementing Rodent Repair Deficiency, Complementation Group 2 (ERCC2) (AA 631-730) antibodyERCC2 适用: 人 ELISA, IF 宿主: 小鼠 Monoclonal 2C9 unconjugated
anti-Excision Repair Cross-Complementing Rodent Repair Deficiency, Complementation Group 2 (ERCC2) (AA 1-300) antibodyERCC2 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Excision Repair Cross-Complementing Rodent Repair Deficiency, Complementation Group 2 (ERCC2) (AA 687-722), (C-Term) antibodyERCC2 适用: 人 WB 宿主: 兔 Polyclonal RB51850 unconjugated
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- 应用备注
- WB 1:1000-3000, ELISA(peptide) 1:20000-1:40000
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 1 mg/mL
- 缓冲液
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C
- 储存方法
- Store at -20 °C. Stable for 12 months from date of receipt.
- 有效期
- 12 months
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- 抗原
- ERCC2 (Excision Repair Cross-Complementing Rodent Repair Deficiency, Complementation Group 2 (ERCC2))
- 别名
- ERCC2 (ERCC2 产品)
- 别名
- COFS2 antibody, EM9 antibody, TTD antibody, XPD antibody, AA407812 antibody, AU020867 antibody, AW240756 antibody, CXPD antibody, Ercc-2 antibody, MGC89573 antibody, CG9433 antibody, DhR3 antibody, DhXPD antibody, DmXPD antibody, Dmel\\CG9433 antibody, ERCC2 antibody, XPD/ERCC2 antibody, l(2)SH2 2137 antibody, l(2)SH2137 antibody, xpd antibody, zgc:56365 antibody, ERCC excision repair 2, TFIIH core complex helicase subunit antibody, excision repair cross-complementing rodent repair deficiency, complementation group 2 antibody, excision repair cross-complementation group 2 antibody, Xeroderma pigmentosum D antibody, ERCC2 antibody, Ercc2 antibody, ercc2 antibody, Xpd antibody
- 背景
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Description: ATP-dependent 5'-3' DNA helicase, component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. The ATP-dependent helicase activity of XPD/ERCC2 is required for DNA opening. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module CAK controls the initiation of transcription. XPD/ERCC2 acts by forming a bridge between CAK and the core-TFIIH complex. Involved in the regulation of vitamin-D receptor activity. As part of the mitotic spindle-associated MMXD complex it plays a role in chromosome segregation. Might have a role in aging process and could play a causative role in the generation of skin cancers.
Gene: ERCC2
- 分子量
- 87kDa
- 基因ID
- 2068
- UniProt
- P18074
- 途径
- DNA Damage Repair
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