-
- 抗原 See all JMY 抗体
- JMY (Junction Mediating and Regulatory Protein, P53 Cofactor (JMY))
-
抗原表位
- N-Term
-
适用
- 人, 小鼠, 大鼠, Cow, 豚鼠
-
宿主
- 兔
-
克隆类型
- 多克隆
-
标记
- This JMY antibody is un-conjugated
-
应用范围
- Western Blotting (WB)
- 序列
- VFIVAWNEIE GKFAITCHNR TAQRQRSGSR EQAGARGGAE AGGAASDGSR
- 预测反应
- Cow: 86%, Guinea Pig: 93%, Human: 100%, Mouse: 100%, Rat: 100%
- 产品特性
- This is a rabbit polyclonal antibody against JMY. It was validated on Western Blot.
- 纯化方法
- Affinity Purified
- Top Product
- Discover our top product JMY Primary Antibody
-
anti-Junction Mediating and Regulatory Protein, P53 Cofactor (JMY) (AA 535-634) antibody
JMY 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 5B6 unconjugated
anti-Junction Mediating and Regulatory Protein, P53 Cofactor (JMY) (AA 535-634) antibodyJMY 适用: 人 WB, ELISA, IF 宿主: 小鼠 Monoclonal 2D7 unconjugated
anti-Junction Mediating and Regulatory Protein, P53 Cofactor (JMY) (AA 708-848) antibodyJMY 适用: 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Junction Mediating and Regulatory Protein, P53 Cofactor (JMY) (AA 2-29), (N-Term) antibodyJMY 适用: 人 WB 宿主: 兔 Polyclonal RB30560 unconjugated
anti-Junction Mediating and Regulatory Protein, P53 Cofactor (JMY) (AA 535-634) antibodyJMY 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-Junction Mediating and Regulatory Protein, P53 Cofactor (JMY) (C-Term) antibodyJMY 适用: 人, 小鼠, 大鼠 WB, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Junction Mediating and Regulatory Protein, P53 Cofactor (JMY) (AA 401-500) antibodyJMY 适用: 小鼠, 大鼠 WB, ELISA, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Junction Mediating and Regulatory Protein, P53 Cofactor (JMY) (C-Term) antibodyJMY 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Junction Mediating and Regulatory Protein, P53 Cofactor (JMY) (C-Term) antibodyJMY 适用: 人, 小鼠 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Junction Mediating and Regulatory Protein, P53 Cofactor (JMY) (C-Term) antibodyJMY 适用: 人, 小鼠, Cow, 犬, 小鸡, Pig WB, IHC 宿主: 兔 Polyclonal unconjugated
-
- 应用备注
- Optimal working dilutions should be determined experimentally by the investigator.
- 说明
-
Antigen size: 712 AA
- 限制
- 仅限研究用
-
- 状态
- Liquid
- 浓度
- Lot specific
- 缓冲液
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 注意事项
- Avoid repeated freeze-thaw cycles.
- 储存条件
- -20 °C
- 储存方法
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
-
- 抗原
- JMY (Junction Mediating and Regulatory Protein, P53 Cofactor (JMY))
- 别名
- JMY (JMY 产品)
- 别名
- WHDC1L3 antibody, junction mediating and regulatory protein, p53 cofactor antibody, junction-mediating and regulatory protein antibody, JMY antibody, jmy antibody, Jmy antibody
- 背景
-
JMY acts both as a nuclear p53/TP53-cofactor and a cytoplasmic regulator of actin dynamics depending on conditions. In nucleus, JMY acts as a cofactor that increases p53/TP53 response via its interaction with p300/EP300. JMY increases p53/TP53-dependent transcription and apoptosis, suggesting an important role in p53/TP53 stress response such as DNA damage. In cytoplasm, JMY acts as a nucleation-promoting factor for both branched and unbranched actin filaments. JMY activates the Arp2/3 complex to induce branched actin filament networks. JMY also catalyzes actin polymerization in the absence of Arp2/3, creating unbranched filaments. JMY contributes to cell motility by controlling actin dynamics. JMY may promote the rapid formation of a branched actin network by first nucleating new mother filaments and then activating Arp2/3 to branch off these filaments. The p53/TP53-cofactor and actin activator activities are regulated via its subcellular location.
Alias Symbols: FLJ37870, MGC163496, WHDC1L3
Protein Interaction Partner: CCDC136, UBC, EP300, MDM2, E2F4, E2F3, E2F2, E2F1,
Protein Size: 712 - 分子量
- 82 kDa
- 基因ID
- 133746
- NCBI登录号
- NM_152405, NP_689618
- UniProt
- Q8N9B5
- 途径
- Regulation of Actin Filament Polymerization
-
You are here:
