PRKAR2A 抗体 (Middle Region)
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- 抗原 See all PRKAR2A 抗体
- PRKAR2A (Protein Kinase, CAMP-Dependent, Regulatory, Type II, alpha (PRKAR2A))
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抗原表位
- Middle Region
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适用
- 人, 大鼠, 小鼠, 犬, Pig, Cow, 马, 豚鼠, 兔
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This PRKAR2A antibody is un-conjugated
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应用范围
- Western Blotting (WB)
- 序列
- DILVTKDNQT RSVGQYDNRG SFGELALMYN TPRAATIVAT SEGSLWGLDR
- 预测反应
- Cow: 100%, Dog: 100%, Guinea Pig: 93%, Horse: 100%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 93%, Rat: 100%
- 产品特性
- This is a rabbit polyclonal antibody against PRKAR2A. It was validated on Western Blot.
- 纯化方法
- Affinity Purified
- Top Product
- Discover our top product PRKAR2A Primary Antibody
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- 应用备注
- Optimal working dilutions should be determined experimentally by the investigator.
- 说明
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Antigen size: 404 AA
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- Lot specific
- 缓冲液
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 注意事项
- Avoid repeated freeze-thaw cycles.
- 储存条件
- -20 °C
- 储存方法
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- 抗原
- PRKAR2A (Protein Kinase, CAMP-Dependent, Regulatory, Type II, alpha (PRKAR2A))
- 别名
- PRKAR2A (PRKAR2A 产品)
- 别名
- PKR2 antibody, PRKAR2 antibody, prkar2a antibody, zgc:85886 antibody, PRKAR2A antibody, 1110061A24Rik antibody, AI317181 antibody, AI836829 antibody, RII(alpha) antibody, protein kinase cAMP-dependent type II regulatory subunit alpha antibody, protein kinase, cAMP-dependent, regulatory, type II, alpha, B antibody, protein kinase, cAMP-dependent, regulatory, type II, alpha antibody, protein kinase, cAMP dependent regulatory, type II alpha antibody, protein kinase cAMP-dependent type 2 regulatory subunit alpha antibody, PRKAR2A antibody, prkar2ab antibody, Prkar2a antibody
- 背景
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CAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. The protein encoded by this gene is one of the regulatory subunits. This subunit can be phosphorylated by the activated catalytic subunit. It may interact with various A-kinase anchoring proteins and determine the subcellular localization of cAMP-dependent protein kinase. This subunit has been shown to regulate protein transport from endosomes to the Golgi apparatus and further to the endoplasmic reticulum (ER).
Alias Symbols: MGC3606, PKR2, PRKAR2
Protein Interaction Partner: UBC, SUZ12, IMPDH2, GPS1, CSRP1, KPNA6, PRKACB, PRKACA, GCH1, WASF1, VCP, CIRBP, ELAVL1, PJA2, Dynll1, AKAP7, PPP1CB, MYCBPAP, ARFGEF2, AKAP2, RAB32, NBEA, AKAP12, AKAP11, AKAP10, AKAP8, AKAP6, AKAP3, AKAP5, AKAP13, AKAP9, CBFA2T3, SMAD3, AKAP1, CFTR, SMA
Protein Size: 404 - 分子量
- 44 kDa
- 基因ID
- 5576
- NCBI登录号
- NM_004157, NP_004148
- UniProt
- P13861
- 途径
- Hedgehog Signaling, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Myometrial Relaxation and Contraction, G-protein mediated Events, Interaction of EGFR with phospholipase C-gamma, SARS-CoV-2 Protein Interactome, The Global Phosphorylation Landscape of SARS-CoV-2 Infection
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