PRKAR2A 抗体
(Protein Kinase, CAMP-Dependent, Regulatory, Type II, alpha (PRKAR2A))
cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. The protein encoded by this gene is one of the regulatory subunits. This subunit can be phosphorylated by the activated catalytic subunit. It may interact with various A-kinase anchoring proteins and determine the subcellular localization of cAMP-dependent protein kinase. This subunit has been shown to regulate protein transport from endosomes to the Golgi apparatus and further to the endoplasmic reticulum (ER). [provided by RefSeq, Jul 2008].
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PRKAR2A
适用: 人, 小鼠, 大鼠, Pig, Cow, 犬, 马
WB
宿主: 兔
Polyclonal
unconjugated
1 image
PRKAR2A
适用: 人, 小鼠, 大鼠, Pig
WB, IHC, IP, IHC (p), IF (cc)
宿主: 兔
Monoclonal
4H11
unconjugated
Latest Publications for our PRKAR2A 抗体
: "Myomegalin is a novel A-kinase anchoring protein involved in the phosphorylation of cardiac myosin binding protein C." in: BMC cell biology, Vol. 12, pp. 18, (2011) (PubMed).
: "Endosome-to-Golgi transport is regulated by protein kinase A type II alpha." in: The Journal of biological chemistry, Vol. 278, Issue 3, pp. 1991-7, (2003) (PubMed).
: "Human myometrial quiescence and activation during gestation and parturition involve dramatic changes in expression and activity of particulate type II (RII alpha) protein kinase A holoenzyme." in: The Journal of clinical endocrinology and metabolism, Vol. 88, Issue 5, pp. 2194-205, (2003) (PubMed).
: "A-kinase anchoring protein AKAP220 binds to glycogen synthase kinase-3beta (GSK-3beta ) and mediates protein kinase A-dependent inhibition of GSK-3beta." in: The Journal of biological chemistry, Vol. 277, Issue 40, pp. 36955-61, (2002) (PubMed).
: "MTG8 proto-oncoprotein interacts with the regulatory subunit of type II cyclic AMP-dependent protein kinase in lymphocytes." in: Oncogene, Vol. 20, Issue 43, pp. 6225-32, (2001) (PubMed).
: "Association of immature hypophosphorylated protein kinase cepsilon with an anchoring protein CG-NAP." in: The Journal of biological chemistry, Vol. 275, Issue 44, pp. 34592-6, (2000) (PubMed).
: "Scar/WAVE-1, a Wiskott-Aldrich syndrome protein, assembles an actin-associated multi-kinase scaffold." in: The EMBO journal, Vol. 19, Issue 17, pp. 4589-600, (2000) (PubMed).
: "Protein kinase A associates with cystic fibrosis transmembrane conductance regulator via an interaction with ezrin." in: The Journal of biological chemistry, Vol. 275, Issue 19, pp. 14360-6, (2000) (PubMed).
: "Structure and function of cyclic nucleotide-dependent protein kinases." in: Annual review of physiology, Vol. 56, pp. 237-72, (1994) (PubMed).
: "The two mRNA forms for the type I alpha regulatory subunit of cAMP-dependent protein kinase from human testis are due to the use of different polyadenylation site signals." in: Biochemical and biophysical research communications, Vol. 167, Issue 1, pp. 323-30, (1990) (PubMed).
: "Endosome-to-Golgi transport is regulated by protein kinase A type II alpha." in: The Journal of biological chemistry, Vol. 278, Issue 3, pp. 1991-7, (2003) (PubMed).
: "Human myometrial quiescence and activation during gestation and parturition involve dramatic changes in expression and activity of particulate type II (RII alpha) protein kinase A holoenzyme." in: The Journal of clinical endocrinology and metabolism, Vol. 88, Issue 5, pp. 2194-205, (2003) (PubMed).
: "A-kinase anchoring protein AKAP220 binds to glycogen synthase kinase-3beta (GSK-3beta ) and mediates protein kinase A-dependent inhibition of GSK-3beta." in: The Journal of biological chemistry, Vol. 277, Issue 40, pp. 36955-61, (2002) (PubMed).
: "MTG8 proto-oncoprotein interacts with the regulatory subunit of type II cyclic AMP-dependent protein kinase in lymphocytes." in: Oncogene, Vol. 20, Issue 43, pp. 6225-32, (2001) (PubMed).
: "Association of immature hypophosphorylated protein kinase cepsilon with an anchoring protein CG-NAP." in: The Journal of biological chemistry, Vol. 275, Issue 44, pp. 34592-6, (2000) (PubMed).
: "Scar/WAVE-1, a Wiskott-Aldrich syndrome protein, assembles an actin-associated multi-kinase scaffold." in: The EMBO journal, Vol. 19, Issue 17, pp. 4589-600, (2000) (PubMed).
: "Protein kinase A associates with cystic fibrosis transmembrane conductance regulator via an interaction with ezrin." in: The Journal of biological chemistry, Vol. 275, Issue 19, pp. 14360-6, (2000) (PubMed).
: "Structure and function of cyclic nucleotide-dependent protein kinases." in: Annual review of physiology, Vol. 56, pp. 237-72, (1994) (PubMed).
: "The two mRNA forms for the type I alpha regulatory subunit of cAMP-dependent protein kinase from human testis are due to the use of different polyadenylation site signals." in: Biochemical and biophysical research communications, Vol. 167, Issue 1, pp. 323-30, (1990) (PubMed).
Aliases for PRKAR2A 抗体
protein kinase cAMP-dependent type II regulatory subunit alpha (PRKAR2A) 抗体protein kinase, cAMP-dependent, regulatory, type II, alpha, B (prkar2ab) 抗体
protein kinase, cAMP-dependent, regulatory, type II, alpha (PRKAR2A) 抗体
protein kinase, cAMP dependent regulatory, type II alpha (Prkar2a) 抗体
protein kinase cAMP-dependent type 2 regulatory subunit alpha (Prkar2a) 抗体
protein kinase cAMP-dependent type II regulatory subunit alpha (Prkar2a) 抗体
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