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MDM2 抗体 (pSer186, pSer188)

Name: MDM2 抗体 (pSer186, pSer188)
SKU: ABIN2568351
Availability: OutOfStock

MDM2 适用: 人 IF 宿主: 兔 Polyclonal unconjugated

产品编号 ABIN2568351

发货至: 中国

Datasheet as PDF

抗原 See all MDM2 抗体

MDM2 (Mdm2, p53 E3 Ubiquitin Protein Ligase Homolog (Mouse) (MDM2))
抗原表位
25

25

14

10

10

10

9

8

8

8

8

4

4

4

4

3

3

3

2

2

2

2

2

2

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1
pSer186, pSer188
适用
190

77

52

11

2

1

1

1

1

1
人
宿主
166

27

1
兔
Compatible Secondaries
克隆类型
167

27
多克隆
标记
96

13

9

9

7

6

4

4

4

4

4

4

2

2

2

2

2

2

2

2

2

2

2

2

2

1

1

1

1
This MDM2 antibody is un-conjugated
应用范围
123

77

63

36

27

27

26

18

18

14

10

10

5

4

3

2

2

1

1

1

1

1
Immunofluorescence (IF)

特异性

The antibody detects endogenous levels of MDM2 only when phosphorylated at serine 186 and serine 188.

纯化方法

Antibodies were purified by affinity-chromatography using epitope-specific peptide.

免疫原

MDM2 (phospho Ser186/Ser188) antibody was raised against a peptide sequence around phosphorylation site of Ser186/Ser188 (H-K-S (p)-D-S (p)-I-S) derived from Human MDM2.

亚型

IgG

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anti-Mdm2, p53 E3 Ubiquitin Protein Ligase Homolog (Mouse) (MDM2) (pSer166) antibody
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anti-Mdm2, p53 E3 Ubiquitin Protein Ligase Homolog (Mouse) (MDM2) (AA 26-169) antibody
MDM2 适用: 人 WB, ELISA, IHC, FACS 宿主: 小鼠 Monoclonal 3C1E3 unconjugated

anti-Mdm2, p53 E3 Ubiquitin Protein Ligase Homolog (Mouse) (MDM2) (AA 393-424) antibody
MDM2 适用: 人, 小鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated

anti-Mdm2, p53 E3 Ubiquitin Protein Ligase Homolog (Mouse) (MDM2) (pSer186) antibody
MDM2 适用: 人 WB, ELISA, IHC (p), IF (p), IF (cc), ICC, IHC (fro) 宿主: 兔 Polyclonal unconjugated

anti-Mdm2, p53 E3 Ubiquitin Protein Ligase Homolog (Mouse) (MDM2) antibody
MDM2 适用: 人, 小鼠, 大鼠 IHC, IF 宿主: 兔 Polyclonal unconjugated

anti-Mdm2, p53 E3 Ubiquitin Protein Ligase Homolog (Mouse) (MDM2) antibody
MDM2 适用: 人, 小鼠, 大鼠, 猴 WB, ELISA, IHC, IF, IP, ICC 宿主: 兔 Polyclonal unconjugated

anti-Mdm2, p53 E3 Ubiquitin Protein Ligase Homolog (Mouse) (MDM2) (AA 119-438) antibody
MDM2 适用: 人 WB, IHC, IHC (p) 宿主: 小鼠 Monoclonal 1E6 unconjugated

anti-Mdm2, p53 E3 Ubiquitin Protein Ligase Homolog (Mouse) (MDM2) (AA 200-430) antibody
MDM2 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated

应用备注

Optimal working dilution should be determined by the investigator.

限制

仅限研究用
状态

Liquid

浓度

1 mg/mL

缓冲液

Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

储存液

Sodium azide

注意事项

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

储存条件

-20 °C

储存方法

Store antibody at -20°C for up to one year.
抗原

MDM2 (Mdm2, p53 E3 Ubiquitin Protein Ligase Homolog (Mouse) (MDM2))

别名

MDM2 (MDM2 产品)

别名

ACTFS antibody, HDMX antibody, hdm2 antibody, zgc:109834 antibody, 1700007J15Rik antibody, AA415488 antibody, Mdm-2 antibody, MDM2 proto-oncogene antibody, MDM2 proto-oncogene S homeolog antibody, Mdm2, p53 E3 ubiquitin protein ligase homolog (mouse) antibody, MDM2 oncogene, E3 ubiquitin protein ligase antibody, transformed mouse 3T3 cell double minute 2 antibody, MDM2 antibody, mdm2.S antibody, Mdm2 antibody, mdm2 antibody

背景

This gene is a target gene of the transcription factor tumor protein p53. The encoded protein is a nuclear phosphoprotein that binds and inhibits transactivation by tumor protein p53, as part of an autoregulatory negative feedback loop. Overexpression of this gene can result in excessive inactivation of tumor protein p53, diminishing its tumor suppressor function. This protein has E3 ubiquitin ligase activity, which targets tumor protein p53 for proteasomal degradation. This protein also affects the cell cycle, apoptosis, and tumorigenesis through interactions with other proteins, including retinoblastoma 1 and ribosomal protein L5. More than 40 different alternatively spliced transcript variants have been isolated from both tumor and normal tissues

分子量

55 kDa

基因ID

4193

NCBI登录号

NP_001138811

UniProt

Q00987

途径

p53 Pathway, PI3K-Akt Signaling, Cell Division Cycle, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Autophagy, Ubiquitin Proteasome Pathway