The antibody detects endogenous levels of IRAK1 only when phosphorylated at serine 376.
纯化方法
Antibodies were purified by affinity-chromatography using epitope-specific peptide.
免疫原
IRAK1 (phospho Ser376) antibody was raised against a peptide sequence around phosphorylation site of Serine 376 (Q-S-S (p)-M-V) derived from Human IRAK1.
IRAK1 encodes the interleukin-1 receptor-associated kinase 1, one of two putative serine/threonine kinases that become associated with the interleukin-1 receptor (IL1R) upon stimulation. IRAK1 is partially responsible for IL1-induced upregulation of the transcription factor NF-kappa B.