IRAK1 抗体 (pThr209)
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- 抗原 See all IRAK1 抗体
- IRAK1 (Interleukin-1 Receptor-Associated Kinase 1 (IRAK1))
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抗原表位
- pThr209
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适用
- 人, 小鼠, 大鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This IRAK1 antibody is un-conjugated
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应用范围
- Western Blotting (WB), Flow Cytometry (FACS), Immunofluorescence (Cultured Cells) (IF (cc)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
- 特异性
- This phosphorylation site is homologous to Thr209 in Mouse and Rat.
- 交叉反应
- 人, 小鼠, 大鼠
- 纯化方法
- Purified by Protein A.
- 免疫原
- KLH conjugated synthetic phosphopeptide derived from human IRAK1 around the phosphorylation site of Thr209 [RG(p-T)HN]
- 亚型
- IgG
- Top Product
- Discover our top product IRAK1 Primary Antibody
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anti-Interleukin-1 Receptor-Associated Kinase 1 (IRAK1) (AA 301-400) antibody
IRAK1 适用: 人, 大鼠 ELISA, FACS, IF (cc), IF (p), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Interleukin-1 Receptor-Associated Kinase 1 (IRAK1) (AA 530-693) antibodyIRAK1 适用: 人 WB, ELISA, IHC (p), IP, IF 宿主: 小鼠 Monoclonal 3F7 unconjugated
anti-Interleukin-1 Receptor-Associated Kinase 1 (IRAK1) (AA 530-693) antibodyIRAK1 适用: 人 WB, ELISA, IHC (p), IP, IF, RNAi 宿主: 小鼠 Monoclonal 3A9 unconjugated
anti-Interleukin-1 Receptor-Associated Kinase 1 (IRAK1) (AA 530-693) antibodyIRAK1 适用: 人 WB, IHC (p), IP, IF, EIA 宿主: 小鼠 Monoclonal 3A9 unconjugated
anti-Interleukin-1 Receptor-Associated Kinase 1 (IRAK1) (AA 348-381), (pSer376) antibodyIRAK1 适用: 人 WB, IHC (p), IF 宿主: 兔 Polyclonal RB56575 unconjugated
anti-Interleukin-1 Receptor-Associated Kinase 1 (IRAK1) (AA 424-633) antibodyIRAK1 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Interleukin-1 Receptor-Associated Kinase 1 (IRAK1) (AA 683-712), (C-Term) antibodyIRAK1 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal RB02337 unconjugated
anti-Interleukin-1 Receptor-Associated Kinase 1 (IRAK1) (AA 683-712) antibodyIRAK1 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Interleukin-1 Receptor-Associated Kinase 1 (IRAK1) (pThr387) antibodyIRAK1 适用: 人, 小鼠, 大鼠 WB, ELISA, FACS, IF (cc), IF (p), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Interleukin-1 Receptor-Associated Kinase 1 (IRAK1) (pThr209) antibodyIRAK1 适用: 人 ELISA, IF (cc), IF (p), IHC (p), IHC (fro), ICC 宿主: 兔 Polyclonal unconjugated
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- 应用备注
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WB 1:300-5000
FCM 1:20-100
IHC-P 1:200-400
IF(ICC) 1:50-200 - 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 1 μg/μL
- 缓冲液
- 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
- 储存液
- ProClin
- 注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- 储存条件
- 4 °C,-20 °C
- 储存方法
- Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
- 有效期
- 12 months
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- 抗原
- IRAK1 (Interleukin-1 Receptor-Associated Kinase 1 (IRAK1))
- 别名
- IRAK1 (IRAK1 产品)
- 别名
- IRAK1 antibody, IRAK antibody, pelle antibody, AA408924 antibody, IRAK-1 antibody, IRAK1-S antibody, Il1rak antibody, Plpk antibody, mPLK antibody, RGD1563841 antibody, interleukin 1 receptor associated kinase 1 antibody, interleukin-1 receptor-associated kinase 1 antibody, IRAK1 antibody, irak1 antibody, Irak1 antibody
- 背景
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Synonyms: IRAK, pelle, Interleukin-1 receptor-associated kinase 1, IRAK-1, IRAK1
Background: Serine/threonine-protein kinase that plays a critical role in initiating innate immune response against foreign pathogens. Involved in Toll-like receptor (TLR) and IL-1R signaling pathways. Is rapidly recruited by MYD88 to the receptor-signaling complex upon TLR activation. Association with MYD88 leads to IRAK1 phosphorylation by IRAK4 and subsequent autophosphorylation and kinase activation. Phosphorylates E3 ubiquitin ligases Pellino proteins (PELI1, PELI2 and PELI3) to promote pellino-mediated polyubiquitination of IRAK1. Then, the ubiquitin-binding domain of IKBKG/NEMO binds to polyubiquitinated IRAK1 bringing together the IRAK1-MAP3K7/TAK1-TRAF6 complex and the NEMO-IKKA-IKKB complex. In turn, MAP3K7/TAK1 activates IKKs (CHUK/IKKA and IKBKB/IKKB) leading to NF-kappa-B nuclear translocation and activation. Alternatively, phosphorylates TIRAP to promote its ubiquitination and subsequent degradation. Phosphorylates the interferon regulatory factor 7 (IRF7) to induce its activation and translocation to the nucleus, resulting in transcriptional activation of type I IFN genes, which drive the cell in an antiviral state. When sumoylated, translocates to the nucleus and phosphorylates STAT3.
- 基因ID
- 3654
- UniProt
- P51617
- 途径
- NF-kappaB Signaling, TLR signaling, Neurotrophin Signaling Pathway, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Toll-Like Receptors Cascades
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