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NLRP3 抗体

NLRP3 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN2427660
发货至: 中国
  • 抗原 See all NLRP3 抗体
    NLRP3 (NLR Family, Pyrin Domain Containing 3 (NLRP3))
    适用
    • 90
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    宿主
    • 86
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    克隆类型
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    多克隆
    标记
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    This NLRP3 antibody is un-conjugated
    应用范围
    • 62
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    Western Blotting (WB), ELISA
    纯化方法
    Affinity purification
    免疫原
    Recombinant protein of human NLRP3
    亚型
    IgG
    Top Product
    Discover our top product NLRP3 Primary Antibody
  • 应用备注
    WB 1:200-1:1000
    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    0.1 mg/mL
    缓冲液
    PBS with 0.05 % sodium azide and 50 % glycerol, PH7.4
    储存液
    Sodium azide
    注意事项
    Avoid freeze / thaw cycles.
    储存条件
    -20 °C
    储存方法
    Store at -20°C. Avoid freeze / thaw cycles.
  • 抗原
    NLRP3 (NLR Family, Pyrin Domain Containing 3 (NLRP3))
    别名
    NLRP3 (NLRP3 产品)
    别名
    CIAS1 antibody, Nalp3 antibody, avp antibody, cias1 antibody, nalp3 antibody, pypaf1 antibody, agtavprl antibody, AGTAVPRL antibody, AII antibody, AVP antibody, C1orf7 antibody, CLR1.1 antibody, FCAS antibody, FCU antibody, MWS antibody, NALP3 antibody, PYPAF1 antibody, AII/AVP antibody, Cias1 antibody, Mmig1 antibody, Pypaf1 antibody, NLR family pyrin domain containing-like antibody, NLR family pyrin domain containing 3 antibody, NLR family, pyrin domain containing 3 L homeolog antibody, NLR family, pyrin domain containing 3 antibody, NLRPL antibody, NLRP3 antibody, nlrp3.L antibody, Nlrp3 antibody
    背景
    This gene encodes a pyrin-like protein containing a pyrin domain, a nucleotide-binding site (NBS) domain, and a leucine-rich repeat (LRR) motif. This protein interacts with the apoptosis-associated speck-like protein PYCARD/ASC, which contains a caspase recruitment domain, and is a member of the NALP3 inflammasome complex. This complex functions as an upstream activator of NF-kappaB signaling, and it plays a role in the regulation of inflammation, the immune response, and apoptosis. Mutations in this gene are associated with familial cold autoinflammatory syndrome (FCAS), Muckle-Wells syndrome (MWS), chronic infantile neurological cutaneous and articular (CINCA) syndrome, and neonatal-onset multisystem inflammatory disease (NOMID). Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. Alternative 5' UTR structures are suggested by available data, however, insufficient evidence is available to determine if all of the represented 5' UTR splice patterns are biologically valid.
    分子量
    Calculated MW: 118 kDa
    途径
    Cellular Response to Molecule of Bacterial Origin, Positive Regulation of Endopeptidase Activity, Inflammasome
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