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NLRP3 抗体 (AA 15-120)

Name: NLRP3 抗体 (AA 15-120)
SKU: ABIN1386361
Availability: OutOfStock

This 兔多克隆 antibody specifically detects NLRP3 in WB, IF, IHC (p), IHC (fro) 和 IF (p). It exhibits reactivity toward 人. It has been mentioned in 11+ publications

Decreased cAMP exaggerated acute gouty arthritis in P2Y14R-KO rats. (NLRP3 抗体 (AA 15-120))

Antigen: 2 µg/100 µL Primary: Antiserum, 1:500, 1:1000, 1:2000, 1:4000, 1:8000, 1:16000, 1:32000; Secondary: HRP conjugated Rabbit Anti-Goat IgG at 1: 5000; TMB staining Read the data in Microplate Reader by 450nm. (NLRP3 抗体 (AA 15-120))

ELISA

Formalin-fixed and paraffin embedded mouse embryo labeled with Rabbit Anti Cryopyrin/CIAS1/NALP3 Polyclonal Antibody, Unconjugated (ABIN1386361) at 1:200 followed by conjugation to the secondary antibody and DAB staining (NLRP3 抗体 (AA 15-120))

IHC

Formalin-fixed and paraffin embedded human lung carcinoma labeled with Rabbit Anti Cryopyrin/CIAS1/NALP3 Polyclonal Antibody, Unconjugated (ABIN1386361) at 1:200 followed by conjugation to the secondary antibody and DAB staining (NLRP3 抗体 (AA 15-120))

Upregulated cAMP suppressed acute gouty arthritis in vivo. (NLRP3 抗体 (AA 15-120))

Pyroptosis stress was invalidated once cAMP increased by Forskolin in vitro. (NLRP3 抗体 (AA 15-120))

15 images

(11 references)

产品编号 ABIN1386361

发货至: 中国

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Quick Overview for NLRP3 抗体 (AA 15-120) (ABIN1386361)

抗原

See all NLRP3 抗体

NLRP3 (NLR Family, Pyrin Domain Containing 3 (NLRP3))

适用

人

宿主

兔

克隆类型

多克隆

标记

This NLRP3 antibody is un-conjugated

应用范围

Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Discover our top product NLRP3 Primary Antibody

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AA 15-120

原理

NALP3/CIAS1 Polyclonal Antibody

交叉反应

人, 小鼠, 大鼠

纯化方法

Purified by Protein A.

免疫原

KLH conjugated synthetic peptide derived from human Cryopyrin

亚型

IgG
anti-NLR Family, Pyrin Domain Containing 3 (NLRP3) (AA 1-93), (Pyrin Domain) antibody
NLRP3 适用: 人, 小鼠 WB, IHC, IF, IP 宿主: 小鼠 Monoclonal Cryo-2 unconjugated

anti-NLR Family, Pyrin Domain Containing 3 (NLRP3) (AA 671-1033) antibody
NLRP3 适用: 小鼠 WB 宿主: 兔 Polyclonal unconjugated

anti-NLR Family, Pyrin Domain Containing 3 (NLRP3) (C-Term) antibody
Verified NLRP3 适用: 人 ELISA, IHC, FACS, IF 宿主: 山羊 Polyclonal unconjugated

anti-NLR Family, Pyrin Domain Containing 3 (NLRP3) (C-Term) antibody
NLRP3 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated

anti-NLR Family, Pyrin Domain Containing 3 (NLRP3) (N-Term) antibody
NLRP3 适用: 人, 小鼠, 大鼠 WB, FACS, IHC (p) 宿主: 兔 Polyclonal unconjugated

anti-NLR Family, Pyrin Domain Containing 3 (NLRP3) (N-Term) antibody
NLRP3 适用: 人, 小鼠, 大鼠 WB, IHC, FACS 宿主: 兔 Polyclonal unconjugated

anti-NLR Family, Pyrin Domain Containing 3 (NLRP3) (AA 65-91), (N-Term) antibody
NLRP3 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal RB22404 unconjugated

anti-NLR Family, Pyrin Domain Containing 3 (NLRP3) (AA 158-207) antibody
NLRP3 适用: 人, 犬, 猴 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated

anti-NLR Family, Pyrin Domain Containing 3 (NLRP3) (AA 1-100) antibody
NLRP3 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 3B1 unconjugated

anti-NLR Family, Pyrin Domain Containing 3 (NLRP3) (AA 30-102) antibody
NLRP3 适用: 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated

应用备注

WB(1:500-2000), IHC-P(1:100-500), IHC-F(1:100-500), IF(IHC-P)(1:100-500), IF(1:50-200)

限制

仅限研究用
状态

Liquid

浓度

Lot specific

缓冲液

0.01M TBS ( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

储存液

ProClin

注意事项

This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

储存条件

4 °C,-20 °C

储存方法

Shipped at 4C. Store at -20C for one year. Avoid repeated freeze/thaw cycles.

有效期

12 months
Li, Jiang, Ye, Zhou, Liu, Yang, Hao, Hu: "P2Y14 receptor has a critical role in acute gouty arthritis by regulating pyroptosis of macrophages." in: Cell death & disease, Vol. 11, Issue 5, pp. 394, (2021) (PubMed).

Yang, Cheng, Liu, Liu, Tan, Guan, Guo, Kuang: "Datura Metel L. Ameliorates Imiquimod-Induced Psoriasis-Like Dermatitis and Inhibits Inflammatory Cytokines Production through TLR7/8-MyD88-NF-κB-NLRP3 Inflammasome Pathway." in: Molecules (Basel, Switzerland), Vol. 24, Issue 11, (2019) (PubMed).

Zendedel, Mönnink, Hassanzadeh, Zaminy, Ansar, Habib, Slowik, Kipp, Beyer: "Estrogen Attenuates Local Inflammasome Expression and Activation after Spinal Cord Injury." in: Molecular neurobiology, (2017) (PubMed).

Yu, Liu, Sun, Wang, Wang, Zhao, Dai, Zhao, Zhang, Li, Han, Lu, Dong, Liu, Yu, Li: "Chronic obstructive sleep apnea promotes aortic remodeling in canines through miR-145/Smad3 signaling pathway." in: Oncotarget, Vol. 8, Issue 23, pp. 37705-37716, (2017) (PubMed).

Zhang, Pan, Yang, Fu, Liu, Chi, Zhang, Hong, Ma, Yin: "H3 Relaxin Protects Against Myocardial Injury in Experimental Diabetic Cardiomyopathy by Inhibiting Myocardial Apoptosis, Fibrosis and Inflammation." in: Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, Vol. 43, Issue 4, pp. 1311-1324, (2017) (PubMed).

Fernandez, Miller, Krammer, Gopal, Greenbaum, Bhardwaj: "Ion efflux and influenza infection trigger NLRP3 inflammasome signaling in human dendritic cells." in: Journal of leukocyte biology, Vol. 99, Issue 5, pp. 723-34, (2016) (PubMed).

Zhou, Rivera, Bhosle, Lahaie, Shao, Tahiri, Zhu, Polosa, Dorfman, Beaudry-Richard, Costantino, Lodygensky, Lachapelle, Chemtob: "Choroidal Involution Is Associated with a Progressive Degeneration of the Outer Retinal Function in a Model of Retinopathy of Prematurity: Early Role for IL-1β." in: The American journal of pathology, Vol. 186, Issue 12, pp. 3100-3116, (2016) (PubMed).

Debye, Schmülling, Zhou, Rune, Beyer, Johann: "Neurodegeneration and NLRP3 inflammasome expression in the anterior thalamus of SOD1(G93A) ALS mice." in: Brain pathology (Zurich, Switzerland), (2016) (PubMed).

Heitzer, Kaiser, Kanagaratnam, Zendedel, Hartmann, Beyer, Johann: "Administration of 17β-Estradiol Improves Motoneuron Survival and Down-regulates Inflammasome Activation in Male SOD1(G93A) ALS Mice." in: Molecular neurobiology, (2016) (PubMed).

Zendedel, Johann, Mehrabi, Joghataei, Hassanzadeh, Kipp, Beyer: "Activation and Regulation of NLRP3 Inflammasome by Intrathecal Application of SDF-1a in a Spinal Cord Injury Model." in: Molecular neurobiology, (2015) (PubMed).

Johann, Heitzer, Kanagaratnam, Goswami, Rizo, Weis, Troost, Beyer: "NLRP3 inflammasome is expressed by astrocytes in the SOD1 mouse model of ALS and in human sporadic ALS patients." in: Glia, (2015) (PubMed).
抗原

NLRP3 (NLR Family, Pyrin Domain Containing 3 (NLRP3))

别名

CIAS1

背景

Synonyms: LRR and PYD domains-containing protein 3, AGTAVPRL, AII/AVP antibody Angiotensin/vasopressin receptor AII/AVP like, Angiotensin/vasopressin receptor AII/AVP-like, C1orf7, Caterpiller protein 1.1, CIAS 1, CIAS1, CLR1.1, Cold autoinflammatory syndrome 1, Cold autoinflammatory syndrome 1 protein, Cryopyrin, Familial cold autoinflammatory syndrome, FCAS, FCU, Muckle-Wells syndrome, MWS, NACHT, NACHT LRR and PYD containing protein 3, NALP 3, NALP3, NALP3_HUMAN, NLRP3, PYPAF 1, PYPAF1 antibody PYRIN containing APAF1 like protein 1, PYRIN-containing APAF1-like protein 1.

基因ID

114548

UniProt

Q96P20

途径

Cellular Response to Molecule of Bacterial Origin, Positive Regulation of Endopeptidase Activity, Inflammasome