我们推荐在您的浏览器上开启Javascript，以获得最佳效果。

IGF1 抗体 (AA 49-118) (HRP)

Name: IGF1 抗体 (AA 49-118) (HRP)
SKU: ABIN1992770
Availability: OutOfStock

IGF1 适用: 人 ELISA 宿主: 兔 Polyclonal HRP

产品编号 ABIN1992770

发货至: 中国

Datasheet as PDF

抗原 See all IGF1 抗体

IGF1 (Insulin-Like Growth Factor 1 (IGF1))
抗原表位
18

15

15

9

8

4

3

3

2

2

2

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1
AA 49-118
适用
150

69

61

22

16

9

7

3

2

1
人
宿主
128

50

11

2

1

1
兔
Compatible Secondaries
克隆类型
138

53
多克隆
标记
93

29

13

7

7

5

2

2

2

2

2

2

2

2

2

2

2

2

2

2

1

1

1

1

1

1

1

1

1

1

1
This IGF1 antibody is conjugated to HRP
应用范围
145

76

68

56

41

30

26

26

26

21

15

14

8

8

8

8

7

6

4

2

2

1

1
ELISA

交叉反应

人

纯化方法

>95%, Protein G purified

免疫原

Recombinant Human Insulin-like growth factor I protein (49-118AA)

亚型

IgG

Top Product

Discover our top product IGF1 Primary Antibody
anti-Insulin-Like Growth Factor 1 (IGF1) (AA 49-118) antibody
IGF1 适用: 人 WB, IHC, IP, ICC 宿主: 小鼠 Monoclonal C1 unconjugated

anti-Insulin-Like Growth Factor 1 (IGF1) (AA 49-118) antibody
IGF1 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated

anti-Insulin-Like Growth Factor 1 (IGF1) (AA 49-153) antibody
IGF1 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated

anti-Insulin-Like Growth Factor 1 (IGF1) (Internal Region) antibody
Verified IGF1 适用: 人 WB, IHC, ELISA, IF, FACS 宿主: 山羊 Polyclonal unconjugated

anti-Insulin-Like Growth Factor 1 (IGF1) (AA 115-144) antibody
IGF1 适用: 人 WB, IHC, ELISA, IF, FACS 宿主: 兔 Polyclonal unconjugated

anti-Insulin-Like Growth Factor 1 (IGF1) (AA 49-100) antibody
IGF1 适用: 人, 小鼠, 大鼠, 犬 WB, ELISA, IP, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated

anti-Insulin-Like Growth Factor 1 (IGF1) (AA 33-102) antibody
IGF1 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated

anti-Insulin-Like Growth Factor 1 (IGF1) antibody
IGF1 适用: 人 WB, IHC 宿主: 兔 Monoclonal unconjugated

anti-Insulin-Like Growth Factor 1 (IGF1) (AA 115-144), (C-Term) antibody
IGF1 适用: 人 WB, IF, FACS, IHC (p) 宿主: 兔 Polyclonal RB33711 unconjugated

anti-Insulin-Like Growth Factor 1 (IGF1) antibody (HRP)
IGF1 适用: 人 WB, IHC, IF, ICC 宿主: 兔 Polyclonal HRP

应用备注

Optimal working dilution should be determined by the investigator.

限制

仅限研究用
状态

Liquid

缓冲液

Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

储存液

ProClin

注意事项

This product contains ProClin^TM: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

注意事项

Avoid repeated freeze.
Do NOT add Sodium Azide! Use of Sodium Azide will inhibit enzyme activity of horseradish peroxidase.

储存条件

-20 °C,-80 °C

储存方法

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
抗原

IGF1 (Insulin-Like Growth Factor 1 (IGF1))

别名

IGF1 (IGF1 产品)

别名

IGF-I antibody, IGF1A antibody, IGFI antibody, C730016P09Rik antibody, Igf-1 antibody, Igf-I antibody, Npt2B antibody, IGF-1 antibody, IGFIA antibody, IGF-IB antibody, igf1 antibody, IGF-1L antibody, IGF-1a antibody, IGF1 antibody, igf-1 antibody, igf1-A antibody, igf1.S antibody, xigf1 antibody, insulin like growth factor 1 antibody, insulin-like growth factor 1 antibody, insulin-like growth factor I antibody, insulin like growth factor 1 L homeolog antibody, IGF1 antibody, Igf1 antibody, LOC100136741 antibody, igf1 antibody, LOC678666 antibody, igf1.L antibody, LOC104911603 antibody

背景

Background: Receptor tyrosine kinase which mediates actions of insulin-like growth factor 1 (IGF1). Binds IGF1 with high affinity and IGF2 and insulin (INS) with a lower affinity. The activated IGF1R is involved in cell growth and survival control. IGF1R is crucial for tumor transformation and survival of malignant cell. Ligand binding activates the receptor kinase, leading to receptor autophosphorylation, and tyrosines phosphorylation of multiple substrates, that function as signaling adapter proteins including, the insulin-receptor substrates (IRS1/2), Shc and 14-3-3 proteins. Phosphorylation of IRSs proteins lead to the activation of two main signaling pathways: the PI3K-AKT/PKB pathway and the Ras-MAPK pathway. The result of activating the MAPK pathway is increased cellular proliferation, whereas activating the PI3K pathway inhibits apoptosis and stimulates protein synthesis. Phosphorylated IRS1 can activate the 85 kDa regulatory subunit of PI3K (PIK3R1), leading to activation of several downstream substrates, including protein AKT/PKB. AKT phosphorylation, in turn, enhances protein synthesis through mTOR activation and triggers the antiapoptotic effects of IGFIR through phosphorylation and inactivation of BAD. In parallel to PI3K-driven signaling, recruitment of Grb2/SOS by phosphorylated IRS1 or Shc leads to recruitment of Ras and activation of the ras-MAPK pathway. In addition to these two main signaling pathways IGF1R signals also through the Janus kinase/signal transducer and activator of transcription pathway (JAK/STAT). Phosphorylation of JAK proteins can lead to phosphorylation/activation of signal transducers and activators of transcription (STAT) proteins. In particular activation of STAT3, may be essential for the transforming activity of IGF1R. The JAK/STAT pathway activates gene transcription and may be responsible for the transforming activity. JNK kinases can also be activated by the IGF1R. IGF1 exerts inhibiting activities on JNK activation via phosphorylation and inhibition of MAP3K5/ASK1, which is able to directly associate with the IGF1R.
Aliases: IBP1 antibody, IGF I antibody, IGF IA antibody, IGF IB antibody, IGF-I antibody, Igf1 antibody, IGF1_HUMAN antibody, IGF1A antibody, IGFI antibody, IGFIA antibody, Insulin like growth factor 1 (somatomedin C) antibody, Insulin like growth factor 1 antibody, Insulin like growth factor IA antibody, Insulin like growth factor IB antibody, Insulin-like growth factor I antibody, Mechano growth factor antibody, MGF antibody, OTTHUMP00000195080 antibody, OTTHUMP00000195081 antibody, OTTHUMP00000195082 antibody, OTTHUMP00000195083 antibody, OTTHUMP00000195084 antibody, Somatomedia C antibody, Somatomedin C antibody, Somatomedin-C antibody

UniProt

P05019

途径

RTK signaling, Intracellular Steroid Hormone Receptor Signaling Pathway, Peptide Hormone Metabolism, Hormone Activity, Regulation of Intracellular Steroid Hormone Receptor Signaling, Regulation of Hormone Metabolic Process, Regulation of Hormone Biosynthetic Process, Stem Cell Maintenance, Glycosaminoglycan Metabolic Process, Regulation of Carbohydrate Metabolic Process, Autophagy, Smooth Muscle Cell Migration, Activated T Cell Proliferation, Positive Regulation of fat Cell Differentiation