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FGFR1 抗体 (N-Term)

Name: FGFR1 抗体 (N-Term)
SKU: ABIN1882081
Availability: OutOfStock

FGFR1 适用: 人, 小鼠 WB, IF, IHC (p), FACS 宿主: 兔 Polyclonal RB04521 unconjugated

The anti-FGFR1 Pab (ABIN1882081 and ABIN2841755) is used in Western blot to detect FGFR1 in NIH-3T3 cell lysate. (FGFR1 抗体 (N-Term))

Flow cytometric analysis of MCF-7 cells using FGFR1 Antibody (N-term) (bottom histogram) compared to a negative control cell (top histogram). (FGFR1 抗体 (N-Term))

FACS

Colocalization of A1B3 and FGFR1 using IF. (FGFR1 抗体 (N-Term))

Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. (FGFR1 抗体 (N-Term))

IHC (p)

4 images

(12 references)

产品编号 ABIN1882081

发货至: 中国

Datasheet as PDF

抗原 See all FGFR1 抗体

FGFR1 (Fibroblast Growth Factor Receptor 1 (FGFR1))
抗原表位
33

30

19

19

18

17

16

9

8

8

8

8

8

7

7

5

5

5

4

3

2

2

2

2

2

2

2

2

2

2

2

2

2

2

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1
AA 19-48, N-Term
适用
245

103

100

24

22

15

8

7

4

2

2

1
人, 小鼠
宿主
237

41

1
兔
Compatible Secondaries
克隆类型
229

50
多克隆
标记
124

24

20

17

13

12

7

7

7

7

6

6

5

5

5

5

5

1

1

1

1
This FGFR1 antibody is un-conjugated
应用范围
237

120

63

62

52

35

25

22

20

17

15

9

7

5

2

1
Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Flow Cytometry (FACS)

纯化方法

This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

免疫原

This FGFR1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 19~48 amino acids from the N-terminal region of human FGFR1.

克隆位点

RB04521

亚型

Ig Fraction
anti-Fibroblast Growth Factor Receptor 1 (FGFR1) (AA 236-362) antibody
FGFR1 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated

anti-Fibroblast Growth Factor Receptor 1 (FGFR1) (C-Term) antibody
FGFR1 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated

anti-Fibroblast Growth Factor Receptor 1 (FGFR1) (AA 19-48) antibody
FGFR1 适用: 人, 小鼠 WB, ELISA, IHC, IF, FACS 宿主: 兔 Polyclonal unconjugated

anti-Fibroblast Growth Factor Receptor 1 (FGFR1) (AA 31-150) antibody
FGFR1 适用: 人 WB, ELISA, PLA 宿主: 小鼠 Monoclonal 5E9 unconjugated

anti-Fibroblast Growth Factor Receptor 1 (FGFR1) (pTyr766) antibody
FGFR1 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated

anti-Fibroblast Growth Factor Receptor 1 (FGFR1) (Tyr766) antibody
FGFR1 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated

anti-Fibroblast Growth Factor Receptor 1 (FGFR1) (AA 291-324) antibody
FGFR1 适用: 人, 小鼠 WB, FACS 宿主: 兔 Polyclonal RB50848 unconjugated

anti-Fibroblast Growth Factor Receptor 1 (FGFR1) (AA 806-842), (C-Term) antibody
FGFR1 适用: 人 WB, IF, IHC (p) 宿主: 小鼠 Monoclonal 1440CT772-50-23 unconjugated

anti-Fibroblast Growth Factor Receptor 1 (FGFR1) antibody
FGFR1 适用: 人 WB, IF, IHC (p) 宿主: 小鼠 Monoclonal 4C3 unconjugated

anti-Fibroblast Growth Factor Receptor 1 (FGFR1) (AA 22-376) antibody
FGFR1 适用: 大鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated

应用备注

IF: 1:50~100. WB: 1:1000. IHC-P: 1:50~100. FC: 1:10~50

限制

仅限研究用
状态

Liquid

缓冲液

Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

储存液

Sodium azide

注意事项

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

储存条件

4 °C,-20 °C

有效期

6 months
Hirata, Katayama, Tsuji, Imura, Natsume, Sugahara, Kunieda, Nakamura, Otsuki: "Homeobox family Hoxc localization during murine palate formation." in: Congenital anomalies, Vol. 56, Issue 4, pp. 172-9, (2016) (PubMed).

Mohanan, Temburni, Kappes, Galileo: "L1CAM stimulates glioma cell motility and proliferation through the fibroblast growth factor receptor." in: Clinical & experimental metastasis, Vol. 30, Issue 4, pp. 507-20, (2013) (PubMed).

Kamura, Matsumoto, Fukushi, Fujiwara, Iida, Okada, Iwamoto: "Basic fibroblast growth factor in the bone microenvironment enhances cell motility and invasion of Ewing's sarcoma family of tumours by activating the FGFR1-PI3K-Rac1 pathway." in: British journal of cancer, Vol. 103, Issue 3, pp. 370-81, (2010) (PubMed).

Page, Ambady, Holmes, Vilner, Kole, Kashpur, Huntress, Vojtic, Whitton, Dominko: "Induction of stem cell gene expression in adult human fibroblasts without transgenes." in: Cloning and stem cells, Vol. 11, Issue 3, pp. 417-26, (2009) (PubMed).

Mondrinos, Koutzaki, Lelkes, Finck: "A tissue-engineered model of fetal distal lung tissue." in: American journal of physiology. Lung cellular and molecular physiology, Vol. 293, Issue 3, pp. L639-50, (2007) (PubMed).

Sahni, Francis: "Stimulation of endothelial cell proliferation by FGF-2 in the presence of fibrinogen requires alphavbeta3." in: Blood, Vol. 104, Issue 12, pp. 3635-41, (2004) (PubMed).

Jiao, Greendorfer, Zhang, Zinn, Diglio, Thompson: "Alternatively spliced FGFR-1 isoform signaling differentially modulates endothelial cell responses to peroxynitrite." in: Archives of biochemistry and biophysics, Vol. 410, Issue 2, pp. 187-200, (2003) (PubMed).

Fu, Abu-Khalil, Morrison, Geschwind, Kornblum: "Expression patterns of epidermal growth factor receptor and fibroblast growth factor receptor 1 mRNA in fetal human brain." in: The Journal of comparative neurology, Vol. 462, Issue 2, pp. 265-73, (2003) (PubMed).

Lundin, Rönnstrand, Cross, Hellberg, Lindahl, Claesson-Welsh: "Differential tyrosine phosphorylation of fibroblast growth factor (FGF) receptor-1 and receptor proximal signal transduction in response to FGF-2 and heparin." in: Experimental cell research, Vol. 287, Issue 1, pp. 190-8, (2003) (PubMed).

Kiselyov, Skladchikova, Hinsby, Jensen, Kulahin, Soroka, Pedersen, Tsetlin, Poulsen, Berezin, Bock: "Structural basis for a direct interaction between FGFR1 and NCAM and evidence for a regulatory role of ATP." in: Structure (London, England : 1993), Vol. 11, Issue 6, pp. 691-701, (2003) (PubMed).

Baumann, Kunapuli, Tracy, Cowell: "The oncogenic fusion protein-tyrosine kinase ZNF198/fibroblast growth factor receptor-1 has signaling function comparable with interleukin-6 cytokine receptors." in: The Journal of biological chemistry, Vol. 278, Issue 18, pp. 16198-208, (2003) (PubMed).

Hauge: "[Expeditions to high altitudes--what can we learn from them?]." in: Tidsskrift for den Norske lægeforening : tidsskrift for praktisk medicin, ny række, Vol. 111, Issue 8, pp. 926-8, (1991) (PubMed).
抗原

FGFR1 (Fibroblast Growth Factor Receptor 1 (FGFR1))

别名

FGFR1 (FGFR1 产品)

别名

FGFR antibody, fgfr antibody, X1FGFR antibody, XFGFR-1 antibody, XFGFRA2 antibody, bfgfr antibody, cek antibody, fgfr1 antibody, flg antibody, flt-2 antibody, flt2 antibody, kal2 antibody, ogd antibody, xfgfr1 antibody, CG7223 antibody, CT22273 antibody, CT39172 antibody, DFGF-R1 antibody, DFGF-R2 antibody, DFR-1 antibody, DFR1 antibody, DFR1/DFGF-R2 antibody, DPR3 antibody, DTRK(FR1) antibody, Dfr-1 antibody, Dfr1 antibody, DmHD-38 antibody, Dmel\\CG7223 antibody, Dtk1 antibody, EMS2 antibody, FGF-R2 antibody, FGFR2 antibody, FR1 antibody, Fr1 antibody, HD-38 antibody, HTL/FGFR1 antibody, Htl antibody, Tk1 antibody, dtk1 antibody, i100 antibody, i150 antibody, i79 antibody, j372 antibody, cd331 antibody, fgfbr antibody, fgfr-1 antibody, hbgfr antibody, n-sam antibody, ach antibody, cd333 antibody, cek2 antibody, fgfr-3 antibody, hsfgfr3ex antibody, jtk4 antibody, BFGFR antibody, CD331 antibody, CEK antibody, FGFBR antibody, FGFR-1 antibody, FLG antibody, FLT-2 antibody, FLT2 antibody, HBGFR antibody, HH2 antibody, KAL2 antibody, N-SAM antibody, OGD antibody, bFGF-R-1 antibody, AW208770 antibody, Eask antibody, Fgfr-1 antibody, Flt-2 antibody, Hspy antibody, FLG-1 antibody, FGFRI antibody, x1fgfr antibody, cb231 antibody, sb:cb231 antibody, fibroblast growth factor receptor antibody, fibroblast growth factor receptor 1 S homeolog antibody, basic fibroblast growth factor receptor 1 antibody, heartless antibody, fibroblast growth factor receptor 1 antibody, fibroblast growth factor receptor 3 (achondroplasia, thanatophoric dwarfism) L homeolog antibody, Fibroblast growth factor receptor 1 antibody, fibroblast growth factor receptor 1 L homeolog antibody, fibroblast growth factor receptor 1a antibody, FGFR antibody, fgfr antibody, fgfr1.S antibody, CpipJ_CPIJ005849 antibody, htl antibody, fgfr1 antibody, fgfr3.L antibody, FGFR1 antibody, Fgfr1 antibody, fgfr1.L antibody, fgfr1a antibody

背景

FGFR1 is a member of the fibroblast growth factor receptor family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member binds both acidic and basic fibroblast growth factors and is involved in limb induction. Mutations in this gene can lead to Pfeiffer syndrome and Jackson-Weiss syndrome. The genomic organization of the gene is very similar to family members 2-4, encompassing 19 exons that are subject to complex alternative splicing, which allows for structural, tissue expression and ligand affinity variations among the isoforms.

分子量

91868

NCBI登录号

NP_001167534, NP_001167535, NP_001167536, NP_001167537, NP_001167538, NP_056934, NP_075593, NP_075594, NP_075598

UniProt

P11362

途径

RTK signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Sensory Perception of Sound, Stem Cell Maintenance, S100 Proteins