(5 references)-
- 抗原 See all NPC1L1 抗体
- NPC1L1 (NPC1 (Niemann-Pick Disease, Type C1, Gene)-Like 1 (NPC1L1))
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抗原表位
- AA 294-323, N-Term
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适用
- 人
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This NPC1L1 antibody is un-conjugated
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应用范围
- Western Blotting (WB)
- 纯化方法
- This antibody is purified through a protein A column, followed by peptide affinity purification.
- 免疫原
- This NPC1L1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 294-323 amino acids from the N-terminal region of human NPC1L1.
- 克隆位点
- RB42754
- 亚型
- Ig Fraction
- Top Product
- Discover our top product NPC1L1 Primary Antibody
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anti-NPC1 (Niemann-Pick Disease, Type C1, Gene)-Like 1 (NPC1L1) (AA 500-600) antibody
NPC1L1 适用: 小鼠, 大鼠 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-NPC1 (Niemann-Pick Disease, Type C1, Gene)-Like 1 (NPC1L1) (AA 1000-1100) antibodyNPC1L1 适用: 人, 小鼠, 大鼠 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-NPC1 (Niemann-Pick Disease, Type C1, Gene)-Like 1 (NPC1L1) antibodyNPC1L1 适用: 人 ELISA, IHC 宿主: 兔 Monoclonal 4B10 unconjugated Recombinant Antibody
anti-NPC1 (Niemann-Pick Disease, Type C1, Gene)-Like 1 (NPC1L1) (AA 596-610) antibodyNPC1L1 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-NPC1 (Niemann-Pick Disease, Type C1, Gene)-Like 1 (NPC1L1) (N-Term) antibodyNPC1L1 适用: 人 WB, ELISA, ICC, IF 宿主: 兔 Polyclonal unconjugated
anti-NPC1 (Niemann-Pick Disease, Type C1, Gene)-Like 1 (NPC1L1) (AA 1030-1100) antibodyNPC1L1 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
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- 应用备注
- WB: 1:1000
- 限制
- 仅限研究用
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- 状态
- Liquid
- 缓冲液
- Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- 4 °C,-20 °C
- 有效期
- 6 months
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: "Biological, clinical and population relevance of 95 loci for blood lipids. ..." in: Nature, Vol. 466, Issue 7307, pp. 707-13, (2010) (PubMed).
: "A SNP of NPC1L1 affects cholesterol absorption in Japanese." in: Journal of atherosclerosis and thrombosis, Vol. 17, Issue 4, pp. 356-60, (2010) (PubMed).
: "Pharmacogenetic analysis of lipid responses to rosuvastatin in Chinese patients." in: Pharmacogenetics and genomics, Vol. 20, Issue 10, pp. 634-7, (2010) (PubMed).
: "Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study." in: Diabetes Care, Vol. 33, Issue 10, pp. 2250-3, (2010) (PubMed).
: "HNF1alpha and SREBP2 are important regulators of NPC1L1 in human liver." in: Journal of lipid research, Vol. 51, Issue 6, pp. 1354-62, (2010) (PubMed).
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: "Biological, clinical and population relevance of 95 loci for blood lipids. ..." in: Nature, Vol. 466, Issue 7307, pp. 707-13, (2010) (PubMed).
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- 抗原
- NPC1L1 (NPC1 (Niemann-Pick Disease, Type C1, Gene)-Like 1 (NPC1L1))
- 别名
- NPC1L1 (NPC1L1 产品)
- 别名
- NPC1L1 antibody, 9130221N23Rik antibody, Gm243 antibody, NPC11L1 antibody, NPC1 like intracellular cholesterol transporter 1 antibody, NPC1 like 1 antibody, NPC1-like 1 antibody, NPC1L1 antibody, npc1l1 antibody, Npc1l1 antibody
- 背景
- The protein encoded by this gene is a multi-pass membrane protein. It contains a conserved N-terminal Niemann-Pick C1 (NPC1) domain and a putative sterol-sensing domain (SSD) which includes a YQRL motif functioning as a plasma membrane to trans-Golgi network transport signal in other proteins. This protein takes up free cholesterol into cells through vesicular endocytosis and plays a critical role in the absorption of intestinal cholesterol. It also has the ability to transport alpha-tocopherol (vitamin E). The drug ezetimibe targets this protein and inhibits the absorption of intestinal cholesterol and alpha-tocopherol. In addition, this protein may play a critical role in regulating lipid metabolism. Polymorphic variations in this gene are associated with plasma total cholesterol and low-density lipoprotein cholesterol (LDL-C) levels and coronary heart disease (CHD) risk. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
- 分子量
- 148728
- NCBI登录号
- NP_001095118, NP_037521
- UniProt
- Q9UHC9
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