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NPC1L1 抗体

(NPC1 (Niemann-Pick Disease, Type C1, Gene)-Like 1 (NPC1L1))
The protein encoded by this gene is a multi-pass membrane protein. It contains a conserved N-terminal Niemann-Pick C1 (NPC1) domain and a putative sterol-sensing domain (SSD) which includes a YQRL motif functioning as a plasma membrane to trans-Golgi network transport signal in other proteins. This protein takes up free cholesterol into cells through vesicular endocytosis and plays a critical role in the absorption of intestinal cholesterol. It also has the ability to transport alpha-tocopherol (vitamin E). The drug ezetimibe targets this protein and inhibits the absorption of intestinal cholesterol and alpha-tocopherol. In addition, this protein may play a critical role in regulating lipid metabolism. Polymorphic variations in this gene are associated with plasma total cholesterol and low-density lipoprotein cholesterol (LDL-C) levels and coronary heart disease (CHD) risk. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009].

Active filters:

  • 抗原: NPC1L1
  • Primary
Catalog no. 产品 适用 宿主 / 克隆类型 应用 价格和交货时间
ABIN1881583
NPC1L1 抗体 (N-Term) NPC1L1 · Primary Antibody 人 兔 Polyclonal 克隆位点 RB42754
  • WB (Western Blotting: 有验证图片)
  • 400 μL
  • 80 μL
发货至: 中国
ABIN1804672
NPC1L1 抗体 (Internal Region) NPC1L1 · Primary Antibody 人, 小鼠, 大鼠 兔 Polyclonal
  • IHC (Immunohistochemistry: 有验证图片)
  • WB (Western Blotting: 所列应用)
  • IHC (p) (Immunohistochemistry (Paraffin-embedded Sections): 所列应用)
  • 50 μL
发货至: 中国
ABIN791336
NPC1L1 抗体 (AA 596-610) NPC1L1 · Primary Antibody 人 兔 Polyclonal
  • WB (Western Blotting: 所列应用)
  • 100 μL
发货至: 中国
ABIN6144760
NPC1L1 抗体 (AA 1030-1100) NPC1L1 · Primary Antibody 人 兔 Polyclonal
  • WB (Western Blotting: 有验证图片)
  • 100 μL
  • 1 mL
  • 20 μL
  • 500 μL
发货至: 中国
ABIN6263697
NPC1L1 抗体 (N-Term) NPC1L1 · Primary Antibody 人 兔 Polyclonal
  • IF/ICC (Immunofluorescence (fixed cells): 有验证图片)
  • WB (Western Blotting: 所列应用)
  • ICC (Immunocytochemistry: 所列应用)
  • IF (Immunofluorescence: 所列应用)
  • 100 μL
  • 200 μL
发货至: 中国
ABIN7127645
Recombinant NPC1L1 抗体 NPC1L1 · Primary Antibody 人 兔 Monoclonal 克隆位点 4B10
  • IHC (Immunohistochemistry: 有验证图片)
  • ELISA (ELISA: 所列应用)
  • 100 μL
  • 50 μL
发货至: 中国
ABIN1918112
NPC1L1 抗体 (AA 294-323) (FITC) NPC1L1 · Primary Antibody 人 兔 Polyclonal
  • WB (Western Blotting: 所列应用)
  • ELISA (ELISA: 所列应用)
  • 200 μL
发货至: 中国
ABIN1918111
NPC1L1 抗体 (AA 294-323) (APC) NPC1L1 · Primary Antibody 人 兔 Polyclonal
  • WB (Western Blotting: 所列应用)
  • ELISA (ELISA: 所列应用)
  • 200 μL
发货至: 中国
ABIN1918113
NPC1L1 抗体 (AA 294-323) (PE) NPC1L1 · Primary Antibody 人 兔 Polyclonal
  • WB (Western Blotting: 所列应用)
  • ELISA (ELISA: 所列应用)
  • 200 μL
发货至: 中国
ABIN596791
NPC1L1 抗体 NPC1L1 · Primary Antibody 人 兔 Polyclonal
  • WB (Western Blotting: 所列应用)
  • IP (Immunoprecipitation: 所列应用)
  • 100 μL
发货至: 中国
ABIN1807106
NPC1L1 抗体 (AA 294-323) NPC1L1 · Primary Antibody 人 兔 Polyclonal
  • WB (Western Blotting: 所列应用)
  • 400 μL
发货至: 中国
ABIN768614
NPC1L1 抗体 (C-Term) NPC1L1 · Primary Antibody 小鼠 山羊 Polyclonal
  • ELISA (ELISA: 所列应用)
  • 100 μg
发货至: 中国
ABIN768613
NPC1L1 抗体 (AA 56-69) NPC1L1 · Primary Antibody 小鼠 山羊 Polyclonal
  • ELISA (ELISA: 所列应用)
  • 100 μg
发货至: 中国
ABIN7605741
NPC1L1 抗体 NPC1L1 · Primary Antibody 人 兔 Monoclonal 克隆位点 21N41
  • WB (Western Blotting: 有验证图片)
  • 100 μL
发货至: 中国
ABIN7842020
NPC1L1 抗体 NPC1L1 · Primary Antibody 人 兔 Polyclonal
  • WB (Western Blotting: 所列应用)
  • 200 μL
发货至: 中国
ABIN8106660
NPC1L1 抗体 (N-Term) NPC1L1 · Primary Antibody 人 兔 Polyclonal
  • WB (Western Blotting: 所列应用)
  • 100 μL
发货至: 中国
Primary Antibody
  • WB (Western Blotting: 有验证图片)
适用
人
宿主
兔
克隆形成能力
Polyclonal
克隆
RB42754
标记
unconjugated
抗体亚型
Ig Fraction
抗原表位
AA 294-323, N-Term
产品编号 ABIN1881583
400 μL (More quantities available)
发货至: 中国
获取报价
Primary Antibody
  • IHC (Immunohistochemistry: 有验证图片)
  • WB (Western Blotting: 所列应用)
  • IHC (p) (Immunohistochemistry (Paraffin-embedded Sections): 所列应用)
适用
人, 小鼠, 大鼠
宿主
兔
克隆形成能力
Polyclonal
标记
unconjugated
抗原表位
Internal Region
产品编号 ABIN1804672
Primary Antibody
  • WB (Western Blotting: 所列应用)
适用
人
宿主
兔
克隆形成能力
Polyclonal
标记
unconjugated
抗体亚型
IgG
抗原表位
AA 596-610
产品编号 ABIN791336
Primary Antibody
  • WB (Western Blotting: 有验证图片)
适用
人
宿主
兔
克隆形成能力
Polyclonal
标记
unconjugated
抗体亚型
IgG
抗原表位
AA 1030-1100
产品编号 ABIN6144760
100 μL (More quantities available)
发货至: 中国
获取报价
Primary Antibody
  • IF/ICC (Immunofluorescence (fixed cells): 有验证图片)
  • WB (Western Blotting: 所列应用)
  • ICC (Immunocytochemistry: 所列应用)
  • IF (Immunofluorescence: 所列应用)
适用
人
宿主
兔
克隆形成能力
Polyclonal
标记
unconjugated
抗体亚型
IgG
抗原表位
N-Term
产品编号 ABIN6263697
100 μL (More quantities available)
发货至: 中国
获取报价
Primary Antibody
  • IHC (Immunohistochemistry: 有验证图片)
  • ELISA (ELISA: 所列应用)
适用
人
宿主
兔
克隆形成能力
Monoclonal
克隆
4B10
标记
unconjugated
蛋白类型
Recombinant Antibody
抗体亚型
IgG
产品编号 ABIN7127645
100 μL (More quantities available)
发货至: 中国
获取报价
Primary Antibody
  • WB (Western Blotting: 所列应用)
  • ELISA (ELISA: 所列应用)
适用
人
宿主
兔
克隆形成能力
Polyclonal
标记
FITC
抗体亚型
IgG
抗原表位
AA 294-323
产品编号 ABIN1918112
Primary Antibody
  • WB (Western Blotting: 所列应用)
  • ELISA (ELISA: 所列应用)
适用
人
宿主
兔
克隆形成能力
Polyclonal
标记
APC
抗体亚型
IgG
抗原表位
AA 294-323
产品编号 ABIN1918111
Primary Antibody
  • WB (Western Blotting: 所列应用)
  • ELISA (ELISA: 所列应用)
适用
人
宿主
兔
克隆形成能力
Polyclonal
标记
PE
抗体亚型
IgG
抗原表位
AA 294-323
产品编号 ABIN1918113
Primary Antibody
  • WB (Western Blotting: 所列应用)
  • IP (Immunoprecipitation: 所列应用)
适用
人
宿主
兔
克隆形成能力
Polyclonal
标记
unconjugated
抗体亚型
IgG
产品编号 ABIN596791
Primary Antibody
  • WB (Western Blotting: 所列应用)
适用
人
宿主
兔
克隆形成能力
Polyclonal
标记
unconjugated
抗原表位
AA 294-323
产品编号 ABIN1807106
Primary Antibody
  • ELISA (ELISA: 所列应用)
质量等级
Recent
适用
小鼠
宿主
山羊
克隆形成能力
Polyclonal
标记
unconjugated
抗体亚型
IgG
抗原表位
C-Term
产品编号 ABIN768614
Primary Antibody
  • ELISA (ELISA: 所列应用)
质量等级
Recent
适用
小鼠
宿主
山羊
克隆形成能力
Polyclonal
标记
unconjugated
抗体亚型
IgG
抗原表位
AA 56-69
产品编号 ABIN768613
Primary Antibody
  • WB (Western Blotting: 有验证图片)
适用
人
宿主
兔
克隆形成能力
Monoclonal
克隆
21N41
标记
unconjugated
抗体亚型
IgG
产品编号 ABIN7605741
Primary Antibody
  • WB (Western Blotting: 所列应用)
适用
人
宿主
兔
克隆形成能力
Polyclonal
标记
unconjugated
产品编号 ABIN7842020
Primary Antibody
  • WB (Western Blotting: 所列应用)
适用
人
宿主
兔
克隆形成能力
Polyclonal
标记
unconjugated
抗原表位
N-Term
产品编号 ABIN8106660

Latest Publications for our NPC1L1 抗体

Ontawong, Duangjai, Muanprasat, Pasachan, Pongchaidecha, Amornlerdpison, Srimaroeng: "Lipid-lowering effects of Coffea arabica pulp aqueous extract in Caco-2 cells and hypercholesterolemic rats." in: Phytomedicine : international journal of phytotherapy and phytopharmacology, Vol. 52, pp. 187-197, (2019) (PubMed).

Meng, Gwag, Sui, Park, Zhou, Zhou: "The atypical antipsychotic quetiapine induces hyperlipidemia by activating intestinal PXR signaling." in: JCI insight, Vol. 4, Issue 3, (2019) (PubMed).

Yamamoto, Yamanashi, Takada, Mu, Tanaka, Komine, Suzuki: "Hepatic Expression of Niemann-Pick C1-Like 1, a Cholesterol Reabsorber from Bile, Exacerbates Western Diet-Induced Atherosclerosis in LDL Receptor Mutant Mice." in: Molecular pharmacology, Vol. 96, Issue 1, pp. 47-55, (2019) (PubMed).

Nihei, Nagafuku, Hayamizu, Odagiri, Tamura, Kikuchi, Veillon, Kanoh, Inamori, Arai, Kabayama, Fukase, Inokuchi: "NPC1L1-dependent intestinal cholesterol absorption requires ganglioside GM3 in membrane microdomains." in: Journal of lipid research, Vol. 59, Issue 11, pp. 2181-2187, (2018) (PubMed).

Ahn, Jun, Jang, Lee, Shin: "Duodenal Niemann-Pick C1-like 1 expression was negatively correlated with liver X receptor expression in nonalcoholic fatty liver disease." in: The Korean journal of internal medicine, (2018) (PubMed).

Soayfane, Tercé, Cantiello, Robenek, Nauze, Bézirard, Allart, Payré, Capilla, Cartier, Peres, Al Saati, Théodorou, Nelson, Yen, Collet, Coméra: "Exposure to dietary lipid leads to rapid production of cytosolic lipid droplets near the brush border membrane." in: Nutrition & metabolism, Vol. 13, pp. 48, (2016) (PubMed).

Kikuchi, Orihara, Oikawa, Han, Kuba, Okuda, Satoh, Osaki, Takeuchi, Aita, Matsuzaka, Iwasaki, Yatoh, Sekiya, Yahagi, Suzuki, Sone, Nakagawa, Yamada, Shimano: "Intestinal CREBH overexpression prevents high-cholesterol diet-induced hypercholesterolemia by reducing Npc1l1 expression." in: Molecular metabolism, Vol. 5, Issue 11, pp. 1092-1102, (2016) (PubMed).

Sachdev, Leopold, Bauer, Patankar, Iqbal, Obrowsky, Boverhof, Doktorova, Scheicher, Goeritzer, Kolb, Turnbull, Zimmer, Hoefler, Hussain, Groen, Kratky: "Novel role of a triglyceride-synthesizing enzyme: DGAT1 at the crossroad between triglyceride and cholesterol metabolism." in: Biochimica et biophysica acta, Vol. 1861, Issue 9 Pt A, pp. 1132-41, (2016) (PubMed).

Feng, Zou, Zhang, Li, Lu: "Hypocholesterolemic Activity of Curcumin Is Mediated by Down-regulating the Expression of Niemann-Pick C1-like 1 in Hamsters." in: Journal of agricultural and food chemistry, Vol. 65, Issue 2, pp. 276-280, (2016) (PubMed).

Takada, Yamanashi, Konishi, Yamamoto, Toyoda, Masuo, Yamamoto, Suzuki: "NPC1L1 is a key regulator of intestinal vitamin K absorption and a modulator of warfarin therapy." in: Science translational medicine, Vol. 7, Issue 275, pp. 275ra23, (2015) (PubMed).

Aliases for NPC1L1 抗体

NPC1 like intracellular cholesterol transporter 1 (NPC1L1) 抗体
NPC1 like 1 (npc1l1) 抗体
NPC1-like 1 (npc1l1) 抗体
NPC1 like intracellular cholesterol transporter 1 (Npc1l1) 抗体
9130221N23Rik 抗体
Gm243 抗体
NPC1L1 抗体
NPC11L1 抗体
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