This gene encodes a member of the basic helix-loop-helix and PAS domain-containing family of transcription factors. The encoded protein is localized to the nucleus and may regulate genes involved in neurogenesis. Chromosomal abnormalities that affect the coding potential of this gene are associated with schizophrenia and mental retardation. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2009].
Brunskill, Ehrman, Williams, Klanke, Hammer, Schaefer, Sah, Dorn, Potter, Vorhees: "Abnormal neurodevelopment, neurosignaling and behaviour in Npas3-deficient mice." in: The European journal of neuroscience, Vol. 22, Issue 6, pp. 1265-76, (2005) (PubMed).
Kamnasaran, Muir, Ferguson-Smith, Cox: "Disruption of the neuronal PAS3 gene in a family affected with schizophrenia." in: Journal of medical genetics, Vol. 40, Issue 5, pp. 325-32, (2003) (PubMed).
Brunskill, Witte, Shreiner, Potter: "Characterization of npas3, a novel basic helix-loop-helix PAS gene expressed in the developing mouse nervous system." in: Mechanisms of development, Vol. 88, Issue 2, pp. 237-41, (2000) (PubMed).
Aliases for NPAS3 抗体
neuronal PAS domain protein 3 (npas3) 抗体 neuronal PAS domain protein 3 (NPAS3) 抗体 neuronal PAS domain protein 3 (Npas3) 抗体 4930423H22Rik 抗体 bHLHe12 抗体 MGC145768 抗体 mop6 抗体 MOP6 抗体 pasd6 抗体 PASD6 抗体 trh 抗体