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FAS 抗体 (AA 61-335)

Name: FAS 抗体 (AA 61-335)
Brand: antibodies-online
SKU: ABIN1683066
Availability: OutOfStock

FAS 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated

Western blot analysis of extracts of various cell lines, using FAS antibody. (FAS 抗体 (AA 61-335))

Immunohistochemistry of paraffin-embedded rat spleen using Fas Rabbit pAb (ABIN1683066, ABIN1683065, ABIN5664115 and ABIN6219731) at dilution of 1:100 (40x lens). (FAS 抗体 (AA 61-335))

IHC

2 images

(2 references)

产品编号 ABIN1683066

发货至: 中国

Datasheet as PDF

抗原 See all FAS 抗体

FAS (TNF Receptor Superfamily, Member 6 (FAS))
抗原表位
25

16

16

8

8

6

5

5

4

4

4

4

3

3

3

3

3

2

2

2

2

2

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1
AA 61-335
适用
209

67

62

19

6

4

2

2

1

1
人
宿主
157

86

4

2

1

1

1

1
兔
Compatible Secondaries
克隆类型
155

96

1
多克隆
标记
119

27

25

12

10

7

4

4

3

3

3

3

3

3

3

3

3

2

2

2

2

1

1

1

1

1

1

1

1

1

1
This FAS antibody is un-conjugated
应用范围
162

115

72

63

35

34

30

26

26

20

18

9

8

6

5

4

4

2

2

2

2

1

1
Western Blotting (WB), Immunohistochemistry (IHC)

序列

KPCPPGERKA RDCTVNGDEP DCVPCQEGKE YTDKAHFSSK CRRCRLCDEG HGLEVEINCT RTQNTKCRCK PNFFCNSTVC EHCDPCTKCE HGIIKECTLT SNTKCKEEGS RSNLGWLCLL LLPIPLIVWV KRKEVQKTCR KHRKENQGSH ESPTLNPETV AINLSDVDLS KYITTIAGVM TLSQVKGFVR KNGVNEAKID EIKNDNVQDT AEQKVQLLRN WHQLHGKKEA YDTLIKDLKK ANLCTLAEKI QTIILKDITS DSENSNFRNE IQSLV

交叉反应

人, 小鼠, 大鼠

产品特性

Polyclonal Antibodies

纯化方法

Affinity purification

免疫原

Recombinant fusion protein containing a sequence corresponding to amino acids 61-335 of human Fas (NP_000034.1).

亚型

IgG

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FAS 适用: 大鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated

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anti-TNF Receptor Superfamily, Member 6 (FAS) (AA 1-335) antibody
FAS 适用: 人 WB, ELISA, IP 宿主: 小鼠 Monoclonal 1B6 unconjugated

anti-TNF Receptor Superfamily, Member 6 (FAS) (AA 20-119) antibody
FAS 适用: 人 WB, ELISA, PLA 宿主: 小鼠 Monoclonal 2G3 unconjugated

应用备注

WB,1:500 - 1:1000,IHC,1:50 - 1:100

限制

仅限研究用
缓冲液

PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

储存液

Sodium azide

注意事项

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

储存条件

-20 °C

储存方法

Store at -20°C. Avoid freeze / thaw cycles.
Cao, Liu, Huang, Wang, Jiao, Huo: "SUMO2 modification of Aurora B and its impact on follicular development and atresia in the mouse ovary." in: International journal of molecular medicine, Vol. 41, Issue 6, pp. 3115-3126, (2018) (PubMed).

Liu, Liu, Wang, Du, Chen, Chen, Guo, Weng, Wang, Wang, Wang: "Effects of apigenin on the expression levels of B-cell lymphoma-2, Fas and Fas ligand in renal ischemia-reperfusion injury in rats." in: Experimental and therapeutic medicine, Vol. 14, Issue 6, pp. 5345-5354, (2017) (PubMed).
抗原

FAS (TNF Receptor Superfamily, Member 6 (FAS))

别名

FAS (FAS 产品)

别名

ALPS1A antibody, APO-1 antibody, APT1 antibody, CD95 antibody, FAS1 antibody, FASTM antibody, TNFRSF6 antibody, AI196731 antibody, APO1 antibody, TNFR6 antibody, Tnfrsf6 antibody, lpr antibody, Fas cell surface death receptor antibody, Fas (TNF receptor superfamily member 6) antibody, FAS antibody, Fas antibody, fas antibody

背景

The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contains a death domain. It has been shown to play a central role in the physiological regulation of programmed cell death, and has been implicated in the pathogenesis of various malignancies and diseases of the immune system. The interaction of this receptor with its ligand allows the formation of a death-inducing signaling complex that includes Fas-associated death domain protein (FADD), caspase 8, and caspase 10. The autoproteolytic processing of the caspases in the complex triggers a downstream caspase cascade, and leads to apoptosis. This receptor has been also shown to activate NF-kappaB, MAPK3/ERK1, and MAPK8/JNK, and is found to be involved in transducing the proliferating signals in normal diploid fibroblast and T cells. Several alternatively spliced transcript variants have been described, some of which are candidates for nonsense-mediated mRNA decay (NMD). The isoforms lacking the transmembrane domain may negatively regulate the apoptosis mediated by the full length isoform.,ALPS1A,APO-1,APT1,CD95,FAS1,FASTM,TNFRSF6,FAS,Cell Biology & Developmental Biology,Apoptosis,Mitochondrial Control of Apoptosis,Inhibition of Apoptosis,Death Receptor Signaling Pathway,Immunology & Inflammation,CD markers,Cytokines,TNF,Cell Intrinsic Innate Immunity Signaling Pathway,Neuroscience,Neurodegenerative Diseases,FAS

分子量

9 kDa/11 kDa/14 kDa/16 kDa/24 kDa/35 kDa/37 kDa

基因ID

355

UniProt

P25445

途径

p53 Pathway, Apoptosis, Production of Molecular Mediator of Immune Response, Positive Regulation of Endopeptidase Activity