anti-Senataxin (SETX) 抗体

SETX encodes a protein named for its homology to the Sen1p protein of fungi which has RNA helicase activity encoded by a domain at the C-terminal end of the protein. 再加上,我们可以发Senataxin 试剂盒 (4)和数多这个蛋白质的别的产品。

列出全部抗体 基因 基因ID UniProt
SETX 23064 Q7Z333
SETX 269254 A2AKX3
SETX 362096  
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antibodies-online.cn销售最多的anti-Senataxin 抗体

Showing 10 out of 108 products:

产品编号 适用 宿主 标记 应用范围 图像 规格 供应商 交付 价格 详细
非结合性 IP, WB Western Blot and Immunoprecipitation: Senataxin Antibody [ABIN252880] - Detection of Human Senataxin by Western Blot and Immunoprecipitation. Samples: Whole cell lysate (15 and 50 mcg for WB, 1 mg for IP, 20% of IP loaded) from HeLa cells. Antibodies: Affinity purified rabbit anti-Senataxin antibody ABIN252880 used for WB at 0.1 mcg/ml (A) and 1 mcg/ml (B) and used for IP at 3 mcg/mg lysate. Senataxin was also immunoprecipitated by rabbit anti-Senataxin antibody ABIN252881, which recognizes a downstream epitope. Detection: Chemiluminescence with exposure times of 3 minutes (A) and 30 seconds (B). Immunoprecipitation: Senataxin Antibody [ABIN2528802] - Samples: Whole cell lysate (0.5 or 1.0 mg per IP reaction; 20% of IP loaded) from HeLa cells prepared using NETN lysis buffer. Antibodies: Affinity purified rabbit anti-Senataxin antibody used for IP at 6 ug per reaction. Senataxin was also immunoprecipitated by a previous lot of this antibody and rabbit anti-Senataxin antibody. For blotting immunoprecipitated Senataxin, the antibody was used at 1 ug/ml. Detection: Chemiluminescence with an exposure time of 3 minutes. 100 μL Log in to see 7至9个工作日
$556.31
详细
非结合性 ICC, IF, IHC, IHC (p), IP, WB Immunohistochemistry-Paraffin: Senataxin Antibody [NBP1-94712] - IHC analysis of a formalin fixed paraffin embedded tissue section of human heart (verticle section) using 1:200 dilution of lot A2 of Senataxin antibody. The antibody generated a very strong staining in the cytoplasm and the nuclei of the muscle cells. No signal was found in the perimysium & endomycium (connective tissue) of the section. Immunohistochemistry-Paraffin: Senataxin Antibody [NBP1-94712] - IHC analysis of a formalin fixed paraffin embedded tissue section of human heart (transverse section) using 1:200 dilution of lot A2 of Senataxin antibody. The antibody generated a very strong staining in the cytoplasm and the nuclei of the muscle cells. No signal was found in the perimysium & endomycium area (connective tissue) of the section. 0.1 mL Log in to see 34 Days
$444.19
详细
非结合性 ChIP, IP, WB Western Blot and Immunoprecipitation: Senataxin Antibody [ABIN252881] - Detection of Human Senataxin by Western Blot and Immunoprecipitation. Samples: Whole cell lysate (15 and 50 mcg for WB, 1 mg for IP, 20% of IP loaded) from HeLa cells. Antibodies: Affinity purified rabbit anti-Senataxin antibody ABIN252881 used for WB at 0.4 mcg/ml (A) and 1 mcg/ml (B) and used for IP at 3 mcg/mg lysate. Senataxin was also immunoprecipitated by rabbit anti-Senataxin antibody ABIN252880, which recognizes an upstream epitope. Detection: Chemiluminescence with exposure times of 3 minutes (A) and 30 seconds (B). Western Blot: Senataxin Antibody  - Detection of Human Senataxin by Western Blot. Samples: Whole cell lysate (15 and 50 ug) from HeLa cells prepared using NETN lysis buffer. Antibody: Affinity purified rabbit anti-Senataxin antibody  used for WB at 0.04 ug/ml. Detection: Chemiluminescence with an exposure time of 3 minutes. 100 μL Log in to see 7至9个工作日
$556.31
详细
小鼠 非结合性 ELISA, IF, WB Immunofluorescence of monoclonal antibody to SETX on HeLa cell  (antibody concentration 10 µg/mL). Antibody Reactive Against Recombinant Protein.Western Blot detection against Immunogen (36.52 KDa) . Dilution: 1:500~1000 100 μg Log in to see 8至11个工作日
$461.00
详细
小鼠 非结合性 IF, ELISA, WB Immunofluorescence of monoclonal antibody to SETX on HeLa cell. [antibody concentration 10 ug/ml] SETX monoclonal antibody (M05), clone 2A9. Western Blot analysis of SETX expression in NIH/3T3. 100 μg Log in to see 11至12个工作日
$440.00
详细
小鼠 非结合性 FACS, IHC, IHC (p) Immunohistochemistry-Paraffin: Senataxin Antibody (5D8) [NBP2-52727] - Senataxin antibody clone 5D8 was tested on human prostate tissue sections and generated strong cytoplasmic-nuclear staining in the secretary/basal epithelial cells as well as the dense connective tissue. Flow (Intracellular): Senataxin Antibody (5D8) [NBP2-52727] - An intracellular stain was performed on HepG2 cells with Senataxin Antibody (5D8) antibody NBP2-52727 (blue) and a matched isotype control NBP2-27231 (orange). Cells were fixed with 4% PFA and then permeablized with 0.1% saponin. Cells were incubated in an antibody dilution of 5 ug/mL for 30 minutes at room temperature, followed by mouse F(ab)2 IgG (H+L) APC-conjugated secondary antibody (F0101B, R&D Systems). 0.1 mg Log in to see 7至9个工作日
$415.44
详细
非结合性 IHC, IHC (p) Immunohistochemistry: Senataxin Antibody [NBP2-13300] - Staining of human skeletal muscle shows moderate cytoplasmic positivity in myocytes. Immunohistochemistry-Paraffin: Senataxin Antibody  - Staining of human skeletal muscle shows moderate cytoplasmic positivity in myocytes. 0.1 mL Log in to see 10至13个工作日
$491.63
详细
非结合性 IF (p), IHC (p), WB Formalin-fixed and paraffin embedded muscle of mouse embryo labeled with Anti-Senataxin/SETX Polyclonal Antibody, Unconjugated (ABIN1385872) at 1:200, followed by conjugation to the secondary antibody and DAB staining 100 μL Log in to see 3至7个工作日
$306.90
详细
Alexa Fluor 594 IF (p)   100 μL Log in to see 14至21个工作日
$405.90
详细
Alexa Fluor 555 IF (p)   100 μL Log in to see 14至21个工作日
$405.90
详细

引用最多的anti-Senataxin 抗体

  1. Human Polyclonal SETX Primary Antibody for IP, WB - ABIN252880 : Richard, Feng, Manley: A SUMO-dependent interaction between Senataxin and the exosome, disrupted in the neurodegenerative disease AOA2, targets the exosome to sites of transcription-induced DNA damage. in Genes & development 2013 (PubMed)
    Show all 2 Pubmed References

  2. Human Polyclonal SETX Primary Antibody for ICC, IF - ABIN4352660 : Choudhury, Vs, Mushtaq, Kumar: Altered translational repression of an RNA-binding protein, Elav by AOA2-causative Senataxin mutation. in Synapse (New York, N.Y.) 2017 (PubMed)
    Show all 2 Pubmed References

  3. Human Polyclonal SETX Primary Antibody for ChIP, IP - ABIN252881 : Zhao, Gish, Braunschweig, Li, Ni, Schmitges, Zhong, Liu, Li, Moffat, Vedadi, Min, Pawson, Blencowe, Greenblatt: SMN and symmetric arginine dimethylation of RNA polymerase II C-terminal domain control termination. in Nature 2016 (PubMed)

更多抗Senataxin的相互作用对抗体

Human Senataxin (SETX) interaction partners

  1. Data suggest that senataxin (SETX) functions at DNA double-strand breaks (DSBs) in order to limit translocations and ensure cell viability.

  2. Expression of AOA2-causative form of SETX in Drosophila muscles resulted in an alteration of translational repression of Elav.

  3. The pan (显示 SUPT6H 抗体)-neuronal expression of wild-type or mutant forms of human senataxin induced morphological plasticity at neuromuscular junction synapses.

  4. Novel compound heterozygous mutations of SETX in Chinese AOA2 pedigree were identified, which broaden the mutation spectrum of SETX.

  5. The role of senataxin in regulating gene expression on a genome-wide scale in Ataxia oculomotor apraxia 2 neurons is described.

  6. these data indicate a potentially causal link among inborn errors in SETX, susceptibility to infection and the development of neurologic disorders.

  7. AOA2 with myoclonus associated with mutations in SETX and AFG3L2 (显示 AFG3L2 抗体)

  8. BRCA1/SETX complexes support a DNA repair mechanism that addresses R-loop-based DNA damage at transcriptional pause sites.

  9. Results identify novel genes related to senataxin function in normal and disease states.

  10. genetic variations in the senataxin gene may contribute to Alzheimer's disease pathogenesis in the Taiwanese Han population.

Mouse (Murine) Senataxin (SETX) interaction partners

  1. Results identify novel genes related to senataxin function in normal and disease states.

  2. These data support key roles for senataxin in coordinating meiotic crossing-over with transcription and in gene silencing to protect the integrity of the genome.

Senataxin (SETX) 抗原简介

蛋白简介

This gene encodes a protein named for its homology to the Sen1p protein of fungi which has RNA helicase activity encoded by a domain at the C-terminal end of the protein. The protein encoded by this gene contains a DNA/RNA helicase domain at its C-terminal end which suggests that it may be involved in both DNA and RNA processing. Mutations in this gene have been associated with ataxia-ocular apraxia-2 (AOA2) and an autosomal dominant form of juvenile amyotrophic lateral sclerosis (ALS4).

Gene names and symbols associated with anti-Senataxin (SETX) 抗体

  • senataxin (SETX) 抗体
  • senataxin (setx) 抗体
  • senataxin (Setx) 抗体
  • A130090N03 抗体
  • A930037J23Rik 抗体
  • Als4 抗体
  • AOA2 抗体
  • AW060766 抗体
  • bA479K20.2 抗体
  • mKIAA0625 抗体
  • RGD1565575 抗体
  • SCAR1 抗体
  • Sen1 抗体
  • SETX 抗体
  • wu:fj92h09 抗体

Protein level used designations for anti-Senataxin (SETX) 抗体

senataxin , amyotrophic lateral sclerosis 4 , probable helicase senataxin-like , SEN1 homolog , amyotrophic lateral sclerosis 4 protein , probable helicase senataxin , amyotrophic lateral sclerosis 4 homolog , amyotrophic lateral sclerosis 4 protein homolog , DEAxQ-box helicase , tRNA splicing endonuclease regulator 1

GENE ID SPECIES
100066679 Equus caballus
417170 Gallus gallus
464815 Pan troglodytes
562474 Danio rerio
100090737 Ornithorhynchus anatinus
100145435 Xenopus (Silurana) tropicalis
100405920 Callithrix jacchus
100445729 Pongo abelii
100468613 Ailuropoda melanoleuca
100542448 Meleagris gallopavo
23064 Homo sapiens
269254 Mus musculus
362096 Rattus norvegicus
480691 Canis lupus familiaris
534284 Bos taurus
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