Senataxin 产品
(Senataxin (SETX))
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This gene encodes a protein named for its homology to the Sen1p protein of fungi which has RNA helicase activity encoded by a domain at the C-terminal end of the protein. The protein encoded by this gene contains a DNA/RNA helicase domain at its C-terminal end which suggests that it may be involved in both DNA and RNA processing. Mutations in this gene have been associated with ataxia-ocular apraxia-2 (AOA2) and an autosomal dominant form of juvenile amyotrophic lateral sclerosis (ALS4). [provided by RefSeq, Jul 2008].
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Senataxin 抗体
High quality antibodies with extensive validation data.
Senataxin ELISA试剂盒
Reliable ELISA kits for a wide range of species.
Recommended Senataxin 抗体
Product
Reactivity
Application
Validations
Cat. No.
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Datasheet
Reactivity
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Application
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- (5)
Cat. No.
ABIN565001
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Mouse
Application
WB, ELISA, IF (cc), IF (p), IHC (fro), IHC (p), ICC
Validations
- (1)
Cat. No.
ABIN1385872
Quantity
100 μL
Datasheet
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Cat. No.
ABIN7164533
Quantity
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Latest Publications for our Senataxin Products
: "Sae2/CtIP prevents R-loop accumulation in eukaryotic cells." in: eLife, Vol. 7, (2019) (PubMed).: "Dual Processing of R-Loops and Topoisomerase I Induces Transcription-Dependent DNA Double-Strand Breaks." in: Cell reports, Vol. 28, Issue 12, pp. 3167-3181.e6, (2019) (PubMed).
: "Senataxin resolves RNA:DNA hybrids forming at DNA double-strand breaks to prevent translocations." in: Nature communications, Vol. 9, Issue 1, pp. 533, (2018) (PubMed).
: "A senataxin-associated exonuclease SAN1 is required for resistance to DNA interstrand cross-links." in: Nature communications, Vol. 9, Issue 1, pp. 2592, (2018) (PubMed).
: "Altered translational repression of an RNA-binding protein, Elav by AOA2-causative Senataxin mutation." in: Synapse (New York, N.Y.), Vol. 71, Issue 5, (2017) (PubMed).
: "Functions of Replication Protein A as a Sensor of R Loops and a Regulator of RNaseH1." in: Molecular cell, Vol. 65, Issue 5, pp. 832-847.e4, (2017) (PubMed).
: "SMN and symmetric arginine dimethylation of RNA polymerase II C-terminal domain control termination." in: Nature, Vol. 529, Issue 7584, pp. 48-53, (2016) (PubMed).
: "A SUMO-dependent interaction between Senataxin and the exosome, disrupted in the neurodegenerative disease AOA2, targets the exosome to sites of transcription-induced DNA damage." in: Genes & development, Vol. 27, Issue 20, pp. 2227-32, (2013) (PubMed).
Synonyms and alternative names related to Senataxin
senataxin (SETX), senataxin (setx), senataxin (Setx), A130090N03, A930037J23Rik, ALS4, Als4, AOA2, AW060766, bA479K20.2, mKIAA0625, RGD1565575, SCAR1, Sen1, SETX, wu:fj92h09Protein level used designations for Senataxin
- senataxin
- amyotrophic lateral sclerosis 4
- probable helicase senataxin-like
- SEN1 homolog
- amyotrophic lateral sclerosis 4 protein
- probable helicase senataxin
- amyotrophic lateral sclerosis 4 homolog
- amyotrophic lateral sclerosis 4 protein homolog
- DEAxQ-box helicase
- tRNA splicing endonuclease regulator 1
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