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抗Human WWTR1 抗体:
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抗Rat (Rattus) WWTR1 抗体:
Human Polyclonal WWTR1 Primary Antibody for WB - ABIN153163
Chan, Lim, Guo, Ng, Lee, Hunziker, Zeng, Hong: A role for TAZ in migration, invasion, and tumorigenesis of breast cancer cells. in Cancer research 2008
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Human Polyclonal WWTR1 Primary Antibody for ChIP, ICC - ABIN258561
Strakova, Reed, Ihnatovych: Human transcriptional coactivator with PDZ-binding motif (TAZ) is downregulated during decidualization. in Biology of reproduction 2010
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Human Polyclonal WWTR1 Primary Antibody for ICC, IF - ABIN4357944
Bhat, Salazar, Balasubramaniyan, Wani, Heathcock, Hollingsworth, James, Gumin, Diefes, Kim, Turski, Azodi, Yang, Doucette, Colman, Sulman, Lang, Rao, Copray, Vaillant, Aldape: The transcriptional coactivator TAZ regulates mesenchymal differentiation in malignant glioma. in Genes & development 2011
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Human Polyclonal WWTR1 Primary Antibody for ICC, IF - ABIN4357945
Pathak, Meng, Zhang, Gnosa, Nandy, Adell, Holmlund, Sun: Tafazzin protein expression is associated with tumorigenesis and radiation response in rectal cancer: a study of Swedish clinical trial on preoperative radiotherapy. in PLoS ONE 2014
Yap (显示 YAP1 抗体)/Taz (显示 TAZ 抗体)-Tead activity is necessary and sufficient for optic vesicle progenitors to adopt retinal pigment epithelium identity in zebrafish.
Taz (显示 TAZ 抗体) is required in the anteroposterior patterning of the pronephric progenitor domain in the intermediate mesoderm, acting in part by regulating retinoic acid signaling in the pronephric progenitor field in the intermediate mesoderm.
Taz (显示 TAZ 抗体)-depleted larvae displayed patterning defects in ventral cranial vessels that correlate with lateral displacement of thyroid follicles
When transcriptional coactivators Yap (显示 YAP1 抗体) and Taz (显示 TAZ 抗体) were restricted from interacting with Tead transcription factors through expression of a dominant negative transgene, cardiac precursors failed to migrate completely to the midline.
TAZ (显示 TAZ 抗体) has a critical role in osteoblast differentiation in vivo
These results demonstrate a critical role of the activation of YAP (显示 YAP1 抗体)/TAZ (显示 TAZ 抗体) by disturbed flow in promoting atheroprone phenotypes and atherosclerotic lesion development.
These findings uncover a suppressive role of SYNPO2 (显示 SYNPO2 抗体) in triple-negative breast cancer (TNBC) metastasis via inhibition of YAP (显示 YAP1 抗体)/TAZ (显示 TAZ 抗体), and suggest that SYNPO2 (显示 SYNPO2 抗体) might provide a potential prognosis marker and novel therapeutic strategy.
Study showed that TAZ (显示 TAZ 抗体) and YAP (显示 YAP1 抗体) are commonly activated oncoproteins in sarcomas.
Data show that TAZ (显示 TAZ 抗体), a WW-domain-containing (显示 SAV1 抗体) transcriptional co-activator, could promote the acceleration of cell cycle and cell proliferation through EGFR (显示 EGFR 抗体) pathway.
Data suggested that the co-expression of the Hippo transducers TAZ (显示 TAZ 抗体)/YAP (显示 YAP1 抗体) and CTGF (显示 CTGF 抗体) may be an adverse prognostic factor in male breast cancer.
Studied the effect of TEAD4 (显示 TEAD4 抗体) acylation on its interaction with YAP (显示 YAP1 抗体) and TAZ (显示 TAZ 抗体); found YAP (显示 YAP1 抗体) and TAZ (显示 TAZ 抗体) bind in a similar manner to both acylated and non-acylated TEAD4 (显示 TEAD4 抗体). Also found TEAD4 (显示 TEAD4 抗体) acylation significantly enhances its stability.
adult human and mouse hearts had more Taz (显示 TAZ 抗体) than Yap1 (显示 YAP1 抗体) by mRNA and protein expression and their increases in diseased hearts were proportional and did not change Yap1 (显示 YAP1 抗体)/Taz (显示 TAZ 抗体) ratio. Yap1 (显示 YAP1 抗体), Taz (显示 TAZ 抗体), and Tead1 (显示 TEAD1 抗体) were accumulated in the nuclear fraction and cardiomyocyte nuclei of diseased hearts
CytoD modified MKL1, a coactivator of serum response factor (SRF) regulating CTGF induction, and promoted its nuclear localization.
WIP (显示 WIPF1 抗体) controls tumor growth by boosting signals that stabilize the YAP (显示 YAP1 抗体)/TAZ (显示 TAZ 抗体) complex via a mechanism mediated by the endocytic/endosomal system.
TAZ (显示 TAZ 抗体) is a critical factor for SRC kinase (显示 CSK 抗体)-mediated intestinal tumor formation and regeneration.
A crucial role for YAP (显示 YAP1 抗体) and TAZ (显示 TAZ 抗体) in the maintenance of the postnatal adrenal cortex.
YAP (显示 YAP1 抗体)/TAZ (显示 TAZ 抗体) plays multifaceted roles for endothelial cell behaviors, proliferation, junction assembly, and metabolism in sprouting angiogenesis and barrier formation
Yap (显示 YAP1 抗体) and Taz (显示 TAZ 抗体) leads to impaired epicardial epithelial-to-mesenchymal transition (EMT (显示 ITK 抗体)) and a reduction in epicardial cell proliferation and differentiation into coronary endothelial cells.
This study identifies YAP/TAZ as central mediators of VEGF signaling
TAZ (显示 TAZ 抗体) is required for TGFbeta (显示 TGFB1 抗体) induction of smooth muscle genes and is also required for the differentiated VSMC phenotype; synergy between TAZ (显示 TAZ 抗体) and SRF, and TAZ (显示 TAZ 抗体) and Myocardin (显示 MYOCD 抗体) (MyoC856), in regulating smooth muscle gene activation was observed in primary aortic vascular smooth muscle cells.
Results demonstrate a pivotal role for TAZ (显示 TAZ 抗体) in regulating the differentiation of Treg cells and TH17 cells.
ABL (显示 ABL1 抗体) potentiated the assembly and activation of the RUNX2 (显示 RUNX2 抗体)-TAZ (显示 TAZ 抗体) master transcription factor complex that is required for osteoblastogenesis, while antagonizing PPARgamma (显示 PPARG 抗体)-mediated adipogenesis.
the transcription regulators YAP (显示 YAP1 抗体) and TAZ (显示 TAZ 抗体) localise to the nucleus in the basal layer of skin and are elevated upon wound healing.
These results suggest that vinculin (显示 VCL 抗体) promotes the nuclear localization of transcription factor TAZ (显示 TAZ 抗体) to inhibit the adipocyte differentiation on rigid extracellular matrix.
This gene encodes a binding protein of the 14-3-3 family of proteins that regulate cell cycle progression, differentiation and apoptosis. The encoded protein is a transcriptional co-activator that binds to the PPXY motif present on transcription factors. The gene product contains a WW domain and, in the C-terminus, a conserved PDZ-binding motif. This gene is distinct from the gene encoding tafazzin. Both genes share the gene symbol Taz. Multiple transcript variants encoding different isoforms have been described.
WW domain containing transcription regulator 1
, WW domain-containing transcription regulator protein 1
, WW domain-containing transcription regulator protein 1-like
, transcriptional co-activator with PDZ-binding motif
, transcriptional coactivator with PDZ-binding motif
, transcriptional coactivator with PDZ binding motif
, transcriptional co-activator with PDZ-binding motif (TA)Z
, transcriptional co-activator with PDZ-binding motif (TAZ)