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抗Human WWTR1 抗体:
抗Mouse (Murine) WWTR1 抗体:
抗Rat (Rattus) WWTR1 抗体:
Human Polyclonal WWTR1 Primary Antibody for WB - ABIN153163
Chan, Lim, Guo, Ng, Lee, Hunziker, Zeng, Hong: A role for TAZ in migration, invasion, and tumorigenesis of breast cancer cells. in Cancer research 2008
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Human Polyclonal WWTR1 Primary Antibody for ChIP, ICC - ABIN258561
Strakova, Reed, Ihnatovych: Human transcriptional coactivator with PDZ-binding motif (TAZ) is downregulated during decidualization. in Biology of reproduction 2010
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Human Polyclonal WWTR1 Primary Antibody for ICC, IF - ABIN4357944
Bhat, Salazar, Balasubramaniyan, Wani, Heathcock, Hollingsworth, James, Gumin, Diefes, Kim, Turski, Azodi, Yang, Doucette, Colman, Sulman, Lang, Rao, Copray, Vaillant, Aldape: The transcriptional coactivator TAZ regulates mesenchymal differentiation in malignant glioma. in Genes & development 2011
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Human Polyclonal WWTR1 Primary Antibody for ICC, IF - ABIN4357945
Pathak, Meng, Zhang, Gnosa, Nandy, Adell, Holmlund, Sun: Tafazzin protein expression is associated with tumorigenesis and radiation response in rectal cancer: a study of Swedish clinical trial on preoperative radiotherapy. in PLoS ONE 2014
Yap (显示 YAP1 抗体)/Taz (显示 TAZ 抗体)-Tead activity is necessary and sufficient for optic vesicle progenitors to adopt retinal pigment epithelium identity in zebrafish.
Taz (显示 TAZ 抗体) is required in the anteroposterior patterning of the pronephric progenitor domain in the intermediate mesoderm, acting in part by regulating retinoic acid signaling in the pronephric progenitor field in the intermediate mesoderm.
Taz (显示 TAZ 抗体)-depleted larvae displayed patterning defects in ventral cranial vessels that correlate with lateral displacement of thyroid follicles
When transcriptional coactivators Yap (显示 YAP1 抗体) and Taz (显示 TAZ 抗体) were restricted from interacting with Tead transcription factors through expression of a dominant negative transgene, cardiac precursors failed to migrate completely to the midline.
TAZ (显示 TAZ 抗体) has a critical role in osteoblast differentiation in vivo
YAP (显示 YAP1 抗体)/TAZ (显示 TAZ 抗体) plays multifaceted roles for endothelial cell behaviors, proliferation, junction assembly, and metabolism in sprouting angiogenesis and barrier formation
Activation of GPR81 (显示 GPR81 抗体) decreases intracellular cAMP levels and inhibits PKA activity, leading to activation of TAZ (显示 TAZ 抗体) and upregulation of PD-L1 (显示 CD274 抗体). This study reveals a critical role for lactate in the immune checkpoint pathway and an unexpected function of TAZ (显示 TAZ 抗体) in tumor evasion of the T-cell-mediated immune response.
results provide evidence that TAZ (显示 TAZ 抗体) and miR (显示 MLXIP 抗体)-135b engage in a positive feedback loop to regulate epithelial-mesenchymal transition and metastasis in osteosarcoma, and suggest that both factors can be therapeutic targets for osteosarcoma treatment.
extracellular matrix stiffening sustains vascular cell growth and migration through YAP (显示 YAP1 抗体)/TAZ (显示 TAZ 抗体)-dependent glutaminolysis and anaplerosis
a stiffness-dependent YAP (显示 YAP1 抗体)/TAZ (显示 TAZ 抗体)-mediated positive feedback loop that drives remodeling phenotypes in pulmonary artery smooth muscle cells via reduced COX-2 (显示 COX2 抗体) and prostaglandin activity.
ETAR (显示 EDNRA 抗体) stimulation acted via downstream G-protein Galphaq (显示 GNAQ 抗体)/11 and Rho GTPase (显示 RACGAP1 抗体) to suppress the Hippo pathway, thus leading to YAP (显示 YAP1 抗体)/TAZ (显示 TAZ 抗体) activation, which was required for ETAR (显示 EDNRA 抗体)-induced tumorigenesis. Overall, these results indicate a critical role of the YAP (显示 YAP1 抗体)/TAZ (显示 TAZ 抗体) axis in ETAR (显示 EDNRA 抗体) signaling
Various studies show that in human cancers, the Hippo pathway is frequently deregulated allowing YAP1 (显示 YAP1 抗体) and TAZ (显示 TAZ 抗体) to escape the inhibition by the Hippo pathway. The upregulation of YAP1 (显示 YAP1 抗体) and TAZ (显示 TAZ 抗体) induces epithelial-mesenchymal transition and increases drug resistance in cancer cells. TAZ (显示 TAZ 抗体) is implicated in cancer stemness.[review]
Results demonstrate a pivotal role for TAZ (显示 TAZ 抗体) in regulating the differentiation of Treg cells and TH17 cells.
the transcription regulators YAP (显示 YAP1 抗体) and TAZ (显示 TAZ 抗体) localise to the nucleus in the basal layer of skin and are elevated upon wound healing.
In colorectal carcinoma TIAM1 (显示 TIAM1 抗体) suppresses tumor progression by regulating YAP (显示 YAP1 抗体)/TAZ (显示 TAZ 抗体) activity.
Yap (显示 YAP1 抗体) and Taz (显示 TAZ 抗体) leads to impaired epicardial epithelial-to-mesenchymal transition (EMT (显示 ITK 抗体)) and a reduction in epicardial cell proliferation and differentiation into coronary endothelial cells.
This study identifies YAP/TAZ as central mediators of VEGF signaling
TAZ (显示 TAZ 抗体) is required for TGFbeta (显示 TGFB1 抗体) induction of smooth muscle genes and is also required for the differentiated VSMC phenotype; synergy between TAZ (显示 TAZ 抗体) and SRF, and TAZ (显示 TAZ 抗体) and Myocardin (显示 MYOCD 抗体) (MyoC856), in regulating smooth muscle gene activation was observed in primary aortic vascular smooth muscle cells.
ABL (显示 ABL1 抗体) potentiated the assembly and activation of the RUNX2 (显示 RUNX2 抗体)-TAZ (显示 TAZ 抗体) master transcription factor complex that is required for osteoblastogenesis, while antagonizing PPARgamma (显示 PPARG 抗体)-mediated adipogenesis.
These results suggest that vinculin (显示 VCL 抗体) promotes the nuclear localization of transcription factor TAZ (显示 TAZ 抗体) to inhibit the adipocyte differentiation on rigid extracellular matrix.
TAZ (显示 TAZ 抗体) represents a previously unrecognized factor that contributes to the critical process of steatosis-to-Nonalcoholic Steatohepatitis progression.
both Snail (显示 SNAI1 抗体) and Slug (显示 SNAI2 抗体) are able to form binary complexes with either YAP (显示 YAP1 抗体) or TAZ (显示 TAZ 抗体) that, together, control YAP (显示 YAP1 抗体)/TAZ (显示 TAZ 抗体) transcriptional activity and function throughout mouse development.
This gene encodes a binding protein of the 14-3-3 family of proteins that regulate cell cycle progression, differentiation and apoptosis. The encoded protein is a transcriptional co-activator that binds to the PPXY motif present on transcription factors. The gene product contains a WW domain and, in the C-terminus, a conserved PDZ-binding motif. This gene is distinct from the gene encoding tafazzin. Both genes share the gene symbol Taz. Multiple transcript variants encoding different isoforms have been described.
WW domain containing transcription regulator 1
, WW domain-containing transcription regulator protein 1
, WW domain-containing transcription regulator protein 1-like
, transcriptional co-activator with PDZ-binding motif
, transcriptional coactivator with PDZ-binding motif
, transcriptional coactivator with PDZ binding motif
, transcriptional co-activator with PDZ-binding motif (TA)Z
, transcriptional co-activator with PDZ-binding motif (TAZ)