anti-大鼠 PKC beta 抗体 for Immunofluorescence (Paraffin-embedded Sections)

Recommended PKC beta Antibody (supplied by: Log in to see )

抗原
Protein Kinase C, beta (PRKCB) 抗体
  • PKC-beta
  • PKCB
  • PRKCB1
  • PRKCB2
  • A130082F03Rik
  • PKC-Beta
  • Pkcb
  • Prkcb1
  • Prkcb2
  • PKC-B
  • Prkcb
  • prkcb1
  • zgc:63591
  • PKC
  • PRKCB_tv2
  • protein kinase C beta
  • protein kinase C, beta
  • protein kinase C, beta b
  • PRKCB
  • Prkcb
  • prkcbb
抗原表位
AA 620-673
29
17
16
15
14
9
9
8
8
6
5
4
3
3
3
3
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
适用
人, 小鼠, 大鼠
172
120
119
20
20
14
10
5
4
2
2
2
2
1
1
1
宿主

187
18
8
5
克隆类型
多克隆
标记
This PKC beta antibody is conjugated to Alexa Fluor 594
16
14
6
5
5
5
2
2
1
1
应用范围
Immunofluorescence (Paraffin-embedded Sections) (IF (p))
200
107
94
25
23
14
13
11
8
6
4
3
3
1
1
选项
Supplier
Log in to see
Supplier Product No.
Log in to see
Request

Get this product for free

Submit your validation data for this product and get a full refund. I want to validate this product

Learn more

产品编号 ABIN2805372
$ 405.90
加上运输费 $45.00
Relevance Score ABIN Application Conjugate Host Isotype Epitope Supplier Clonality References Details
1 ABIN2805561 IF (p) Alexa Fluor 594 Rabbit IgG AA 490-520, pThr500 Log in to see Polyclonal 0
1 ABIN5008880 IF (p) Alexa Fluor 750 Rabbit IgG AA 620-673 Log in to see Polyclonal 0
1 ABIN5008879 IF (p) Alexa Fluor 680 Rabbit IgG AA 620-673 Log in to see Polyclonal 0
1 ABIN5009176 IF (p) Alexa Fluor 750 Rabbit IgG AA 490-520, pThr500 Log in to see Polyclonal 0
1 ABIN5009175 IF (p) Alexa Fluor 680 Rabbit IgG AA 490-520, pThr500 Log in to see Polyclonal 0
1 ABIN711446 IF (p) IHC (p) WB Rabbit IgG pSer660 Log in to see Polyclonal 0

General

抗原 Protein Kinase C, beta (PRKCB) 抗体
抗原表位 AA 620-673
(29), (17), (16), (15), (14), (9), (9), (8), (8), (6), (5), (4), (3), (3), (3), (3), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
适用 人, 小鼠, 大鼠
(172), (120), (119), (20), (20), (14), (10), (5), (4), (2), (2), (2), (2), (1), (1), (1)
宿主
(187), (18), (8), (5)
克隆类型
多克隆
标记 This PKC beta antibody is conjugated to Alexa Fluor 594
(16), (14), (6), (5), (5), (5), (2), (2), (1), (1)
应用范围 Immunofluorescence (Paraffin-embedded Sections) (IF (p))
(200), (107), (94), (25), (23), (14), (13), (11), (8), (6), (4), (3), (3), (1), (1)
Supplier Log in to see

PKC beta抗体详情

PKC beta目标详情 使用细节 贮存及处理 图像
特异性 This antibody will recognize isoform Beta-II of Protein kinase C beta
纯化方法 Purified by Protein A.
免疫原 KLH conjugated synthetic peptide derived from human PKC beta 2
亚型 IgG
Plasmids, Primers & others

PKC beta目标详情

PKC beta抗体详情 使用细节 贮存及处理 图像 回页首
抗原
别名 PKC beta (PRKCB Antibody 摘要)
背景

Calcium-activated, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase involved in various cellular processes such as regulation of the B-cell receptor (BCR) signalosome, oxidative stress-induced apoptosis, androgen receptor-dependent transcription regulation, insulin signaling and endothelial cells proliferation. Plays a key role in B-cell activation by regulating BCR-induced NF-kappa-B activation. Mediates the activation of the canonical NF-kappa-B pathway (NFKB1) by direct phosphorylation of CARD11/CARMA1 at 'Ser-559', 'Ser-644' and 'Ser-652'. Phosphorylation induces CARD11/CARMA1 association with lipid rafts and recruitment of the BCL10-MALT1 complex as well as MAP3K7/TAK1, which then activates IKK complex, resulting in nuclear translocation and activation of NFKB1. Plays a direct role in the negative feedback regulation of the BCR signaling, by down-modulating BTK function via direct phosphorylation of BTK at 'Ser-180', which results in the alteration of BTK plasma membrane localization and in turn inhibition of BTK activity. Involved in apoptosis following oxidative damage: in case of oxidative conditions, specifically phosphorylates 'Ser-36' of isoform p66Shc of SHC1, leading to mitochondrial accumulation of p66Shc, where p66Shc acts as a reactive oxygen species producer. Acts as a coactivator of androgen receptor (ANDR)-dependent transcription, by being recruited to ANDR target genes and specifically mediating phosphorylation of 'Thr-6' of histone H3 (H3T6ph), a specific tag for epigenetic transcriptional activation that prevents demethylation of histone H3 'Lys-4' (H3K4me) by LSD1/KDM1A. In insulin signaling, may function downstream of IRS1 in muscle cells and mediate insulin-dependent DNA synthesis through the RAF1-MAPK/ERK signaling cascade. May participate in the regulation of glucose transport in adipocytes by negatively modulating the insulin-stimulated translocation of the glucose transporter SLC2A4/GLUT4.

Subcellular location: Cytoplasm, Nucleus, Cell membrane

Synonyms: PKCB, PRKCB1, PRKCB2, PKC-beta, Protein kinase C beta type, PKC-B, PRKCB

基因ID 5579
UniProt P05771
途径 WNT signaling, TCR Signaling, Thyroid Hormone Synthesis, Nuclear Hormone Receptor Binding, Chromatin Binding, Myometrial Relaxation and Contraction, VEGF Signaling, Unfolded protein response

使用细节

PKC beta抗体详情 PKC beta目标详情 贮存及处理 图像 回页首
应用备注 IF(IHC-P) 1:50-200
限制 仅限研究用

贮存及处理

PKC beta抗体详情 PKC beta目标详情 使用细节 图像 回页首
状态 Liquid
浓度 1 μg/μL
缓冲液 Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.
储存液 Sodium azide
注意事项 This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
储存条件 4 °C
储存方法 Store at 4°C
有效期 12 months