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Human Monoclonal FZD4 Primary Antibody for IHC (fro), FACS - ABIN2689205
Ells, Guernsey, Wallace, Zheng, Vincer, Allen, Ingram, DaSilva, Siebert, Sheidow, Beis, Robitaille: Severe retinopathy of prematurity associated with FZD4 mutations. in Ophthalmic genetics 2010
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Cow (Bovine) Polyclonal FZD4 Primary Antibody for IHC, WB - ABIN2776715
Dufourcq, Leroux, Ezan, Descamps, Lamazière, Costet, Basoni, Moreau, Deutsch, Couffinhal, Duplàa: Regulation of endothelial cell cytoskeletal reorganization by a secreted frizzled-related protein-1 and frizzled 4- and frizzled 7-dependent pathway: role in neovessel formation. in The American journal of pathology 2008
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Human Monoclonal FZD4 Primary Antibody for CyTOF, FACS - ABIN4900304
Baksh, Boland, Tuan: Cross-talk between Wnt signaling pathways in human mesenchymal stem cells leads to functional antagonism during osteogenic differentiation. in Journal of cellular biochemistry 2007
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Human Polyclonal FZD4 Primary Antibody for ELISA, WB - ABIN408660
You, Nguyen, Albers, Lin, Holcombe: Wnt pathway-related gene expression in inflammatory bowel disease. in Digestive diseases and sciences 2008
Human Monoclonal FZD4 Primary Antibody for FACS, ICC - ABIN4898976
Despeaux, Chicanne, Rouer, De Toni-Costes, Bertrand, Mansat-De Mas, Vergnolle, Eaves, Payrastre, Girault, Racaud-Sultan: Focal adhesion kinase splice variants maintain primitive acute myeloid leukemia cells through altered Wnt signaling. in Stem cells (Dayton, Ohio) 2012
Knockdown of Tc-fz1 alone interfered with the formation of the proximo-distal and the dorso-ventral axes during leg development, whereas no effect was observed with single Tc-fz2 (显示 FZD2 抗体) or Tc-fz4 RNAi knockdowns.
FzM1.8 is an allosteric agonist of FZD4. In the absence of any WNT (显示 WNT2 抗体) ligand, FzM1.8 binds to FZD4, promotes recruitment of heterotrimeric G proteins, and biases WNT (显示 WNT2 抗体) signaling toward a noncanonical route that involves PI3K (显示 PIK3CA 抗体). In colon cancer cells, the FZD4/PI3K (显示 PIK3CA 抗体) axis elicited by FzM1.8 preserves stemness and promotes proliferation of undifferentiated cells.
FZD4 Tyrosine 250(2.39) is crucial for DVL2 (显示 DVL2 抗体) interaction and DVL2 (显示 DVL2 抗体) translocation to the plasma membrane.
Accessory proteins in Frizzled (FZD) receptor complexes are thought to determine ligand selectivity and signaling amplitude.
FZD4 was confirmed to be a downstream target of miR (显示 MLXIP 抗体)-505, and found to be up-regulated in cervical cancer patients.
The screening of candidate genes namely NDP (显示 NDP 抗体), FZD4 and TSPAN12 (显示 TSPAN12 抗体) led to the identification of six major coding region variants in 36 ROP (显示 STXBP1 抗体) probands.
Seven novel mutations found in this study have broadened the spectrum of mutations in FZD4 known to cause familial exudative vitreoretinopathy (FEVR (显示 NDP 抗体)), providing a deeper understanding of this disease. The results show that mutations in FZD4 are associated with the phenotypes of retinal folds or ectopic macula in FEVR (显示 NDP 抗体)
Three affected individuals within a family with FEVR (显示 NDP 抗体) presented with variable disease severity. All three affected family members harboured mutation c.349T>C (p.Cys117Arg) in FZD4.
The findings in this family support the concept that some mutated FZD4 alleles can be associated with recessive rather than dominant disease.
novel role of let-7b/Fzd4 axis through wnt (显示 WNT2 抗体) signaling
Study shows that WNT5A (显示 WNT5A 抗体) stimulates dimerization of membrane-anchored FZD4 CRDs and oligomerization of full-length FZD4, which requires the integrity of CRD (显示 CRX 抗体) palmitoleoyl-binding residues. These results suggest that FZD receptors may form signalosomes in response to Wnt (显示 WNT2 抗体) binding through the CRDs and that the Wnt (显示 WNT2 抗体) palmitoleoyl group is important in promoting these interactions.
A splice variant of the Frizzled-4 receptor modulates Wnt (显示 WNT2 抗体) signalling in a dose-dependent, biphasic manner.
These data expose a stromal component that regulates the earliest stages of tumorigenesis in the cerebellum, and a novel role for the Norrin (显示 NDP 抗体)/Fzd4 axis as an endogenous anti-tumor signal in the preneoplastic niche.
Fzd4 and Fzd6 (显示 FZD6 抗体) genes have a deep patterning effect on arterial vessel morphogenesis that may determine its functional efficiency
Study identified a novel Wnt5a (显示 WNT5A 抗体)/Fzd4 signaling pathway that contributes to the regulation of dendrite morphogenesis
These results question the conclusion that a dominant-negative mechanism would explain the dominance of the mutant L501fsX533 Fz4 allele in the transmission of a form of Familial exudative vitreoretinopathy.
The data reveal both cell-autonomous and cell-nonautonomous effects, and they imply a central role for Norrin (显示 NDP 抗体)/Fz4 signaling in central nervous system vascular development and in the maintenance of the blood brain barrier/blood retina barrier state.
Frizzled 4 regulates arterial network organization through noncanonical Wnt (显示 WNT2 抗体)/planar cell polarity signaling.
Frizzled4 wnt (显示 WNT2 抗体) receptors are significantly increased in pathological neovascularization in a mouse model of oxygen-induced proliferative retinopathy.
targeted inactivation of the TSK (显示 FBN1 抗体) gene in mice causes expansion of the ciliary body and up-regulation of Wnt2b (显示 WNT2B 抗体) and Fzd4 expression in the developing peripheral eye
These results demonstrate that FZD4 is required for physiological and pathologic angiogenesis in the retina and for regulation of retinal endothelial cell differentiation.
A major role for frizzled 4 and frizzled 8 (显示 FZD8 抗体) in controlling ureteric growth in the developing kidney.
This gene is a member of the frizzled gene family. Members of this family encode seven-transmembrane domain proteins that are receptors for the Wingless type MMTV integration site family of signaling proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway. This protein may play a role as a positive regulator of the Wingless type MMTV integration site signaling pathway. A transcript variant retaining intronic sequence and encoding a shorter isoform has been described, however, its expression is not supported by other experimental evidence.
, frizzled homolog 1
, frizzled homolog 4
, WNT receptor frizzled-4
, frizzled 4, seven transmembrane spanning receptor
, frizzled receptor 4
, frizzled 4 protein