This gene encodes a member of the family of pyridine nucleotide oxidoreductases. This protein reduces thioredoxins as well as other substrates, and plays a role in selenium metabolism and protection against oxidative stress. The functional enzyme is thought to be a homodimer which uses FAD as a cofactor. Each subunit contains a selenocysteine (Sec) residue which is required for catalytic activity. The selenocysteine is encoded by the UGA codon that normally signals translation termination. The 3' UTR of selenocysteine-containing genes have a common stem-loop structure, the sec insertion sequence (SECIS), that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Alternative splicing results in several transcript variants encoding the same or different isoforms. [provided by RefSeq, Jul 2008].
Seale, Ha, Hashimoto, Berry: "Relationship between selenoprotein P and selenocysteine lyase: Insights into selenium metabolism." in: Free radical biology & medicine, Vol. 127, pp. 182-189, (2018) (PubMed).
Fan, Makar, Wang, Ai: "Monitoring thioredoxin redox with a genetically encoded red fluorescent biosensor." in: Nature chemical biology, Vol. 13, Issue 9, pp. 1045-1052, (2017) (PubMed).
Kaya, Çiçek, Erdi, Findik, Karatas, Esen, Keskin, Kalkan: "Intratumoral hemorrhage-related differences in the expression of vascular endothelial growth factor, basic fibroblast growth factor and thioredoxin reductase 1 in human glioblastoma." in: Molecular and clinical oncology, Vol. 5, Issue 4, pp. 343-346, (2016) (PubMed).
Reiser, Mathys, Curbo, Pannecouque, Noppen, Liekens, Engman, Lundberg, Balzarini, Karlsson: "The Cellular Thioredoxin-1/Thioredoxin Reductase-1 Driven Oxidoreduction Represents a Chemotherapeutic Target for HIV-1 Entry Inhibition." in: PLoS ONE, Vol. 11, Issue 1, pp. e0147773, (2016) (PubMed).
Mustacich, Powis: "Thioredoxin reductase." in: The Biochemical journal, Vol. 346 Pt 1, pp. 1-8, (2000) (PubMed).
Gasdaska, Gasdaska, Cochran, Powis: "Cloning and sequencing of a human thioredoxin reductase." in: FEBS letters, Vol. 373, Issue 1, pp. 5-9, (1995) (PubMed).