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TXNRD1 产品

(Thioredoxin Reductase 1 (TXNRD1))

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This gene encodes a member of the family of pyridine nucleotide oxidoreductases. This protein reduces thioredoxins as well as other substrates, and plays a role in selenium metabolism and protection against oxidative stress. The functional enzyme is thought to be a homodimer which uses FAD as a cofactor. Each subunit contains a selenocysteine (Sec) residue which is required for catalytic activity. The selenocysteine is encoded by the UGA codon that normally signals translation termination. The 3' UTR of selenocysteine-containing genes have a common stem-loop structure, the sec insertion sequence (SECIS), that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Alternative splicing results in several transcript variants encoding the same or different isoforms. [provided by RefSeq, Jul 2008].

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Featured TXNRD1 Categories

TXNRD1 抗体

High quality antibodies with extensive validation data.

TXNRD1 ELISA试剂盒

Reliable ELISA kits for a wide range of species.

TXNRD1 蛋白

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended TXNRD1 抗体

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Mouse
Application WB, IHC, IP, ICC
Validations
  • (8)
Cat. No. ABIN7432433
Quantity 100 μL
Datasheet Datasheet
Reactivity Human, Mouse, Rat
Application WB, ELISA, IHC (p), IF (cc), IF (p), IHC (fro)
Validations
  • (1)
  • (4)
Cat. No. ABIN1386102
Quantity 100 μL
Datasheet Datasheet
Reactivity Human, Mouse, Rat
Application IHC, IF
Validations
  • (5)
Cat. No. ABIN7259296
Quantity 200 μL
Datasheet Datasheet

Recommended TXNRD1 ELISA试剂盒

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6962389
Quantity 96 tests
Datasheet Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6973702
Quantity 96 tests
Datasheet Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6959909
Quantity 96 tests
Datasheet Datasheet

Recommended TXNRD1 蛋白

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1324248
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
  • (1)
Cat. No. ABIN5569811
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
  • (1)
Cat. No. ABIN7125363
Quantity 50 μg
Datasheet Datasheet

Latest Publications for our TXNRD1 Products

Seale, Ha, Hashimoto, Berry: "Relationship between selenoprotein P and selenocysteine lyase: Insights into selenium metabolism." in: Free radical biology & medicine, Vol. 127, pp. 182-189, (2018) (PubMed).

Fan, Makar, Wang, Ai: "Monitoring thioredoxin redox with a genetically encoded red fluorescent biosensor." in: Nature chemical biology, Vol. 13, Issue 9, pp. 1045-1052, (2017) (PubMed).

Kaya, Çiçek, Erdi, Findik, Karatas, Esen, Keskin, Kalkan: "Intratumoral hemorrhage-related differences in the expression of vascular endothelial growth factor, basic fibroblast growth factor and thioredoxin reductase 1 in human glioblastoma." in: Molecular and clinical oncology, Vol. 5, Issue 4, pp. 343-346, (2016) (PubMed).

Reiser, Mathys, Curbo, Pannecouque, Noppen, Liekens, Engman, Lundberg, Balzarini, Karlsson: "The Cellular Thioredoxin-1/Thioredoxin Reductase-1 Driven Oxidoreduction Represents a Chemotherapeutic Target for HIV-1 Entry Inhibition." in: PLoS ONE, Vol. 11, Issue 1, pp. e0147773, (2016) (PubMed).

Nguyen, Awwad, Smart, Spitz, Gius: "Thioredoxin reductase as a novel molecular target for cancer therapy." in: Cancer letters, Vol. 236, Issue 2, pp. 164-74, (2006) (PubMed).

Urig, Becker: "On the potential of thioredoxin reductase inhibitors for cancer therapy." in: Seminars in cancer biology, Vol. 16, Issue 6, pp. 452-65, (2006) (PubMed).

Mustacich, Powis: "Thioredoxin reductase." in: The Biochemical journal, Vol. 346 Pt 1, pp. 1-8, (2000) (PubMed).

Gasdaska, Gasdaska, Cochran, Powis: "Cloning and sequencing of a human thioredoxin reductase." in: FEBS letters, Vol. 373, Issue 1, pp. 5-9, (1995) (PubMed).

Synonyms and alternative names related to TXNRD1

thioredoxin reductase 1 (TXNRD1), thioredoxin reductase 1 (txnrd1), thioredoxin reductase 1 (Trxr-1), thioredoxin reductase 1 L homeolog (txnrd1.L), NADPH-dependent thioredoxin reductase C (NTRC), ThioRedoXin Reductase (trxr-1), thioredoxin reductase 1 (Txnrd1), cb682, fb83a08, GB14972, GRIM-12, MGC85342, NADPH-dependent thioredoxin reductase C, T32G6.20, T32G6_20, TR, Tr, TR1, TrxR1, TRXR1, TXNR, wu:fb83a08

Protein level used designations for TXNRD1

  • thioredoxin reductase 1, cytoplasmic
  • thioredoxin reductase 3
  • thioredoxin reductase 1
  • thioredoxin reductase 1, cytoplasmic-like
  • KM-102-derived reductase-like factor
  • gene associated with retinoic and IFN-induced mortality 12 protein
  • gene associated with retinoic and interferon-induced mortality 12 protein
  • oxidoreductase
  • thioredoxin reductase GRIM-12
  • thioredoxin reductase TR1
  • TR
  • redox enzyme thioredoxin reductase
  • NADPH-dependent thioredoxin reductase
  • selenoprotein oxidoreductase
  • TR alpha
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