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TYMS 产品

(Thymidylate Synthetase (TYMS))

Categories

Thymidylate synthase catalyzes the methylation of deoxyuridylate to deoxythymidylate using 5,10-methylenetetrahydrofolate (methylene-THF) as a cofactor. This function maintains the dTMP (thymidine-5-prime monophosphate) pool critical for DNA replication and repair. The enzyme has been of interest as a target for cancer chemotherapeutic agents. It is considered to be the primary site of action for 5-fluorouracil, 5-fluoro-2-prime-deoxyuridine, and some folate analogs. Expression of this gene and that of a naturally occuring antisense transcript rTSalpha (GeneID:55556) vary inversely when cell-growth progresses from late-log to plateau phase. [provided by RefSeq, Jul 2008].

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Featured TYMS Categories

TYMS 抗体

High quality antibodies with extensive validation data.

TYMS ELISA试剂盒

Reliable ELISA kits for a wide range of species.

TYMS 蛋白

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended TYMS 抗体

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application WB, IHC, IP, ICC
Validations
  • (8)
Cat. No. ABIN7436399
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB, IF, FACS, IHC, ISt, RIA, StM
Validations
  • (7)
Cat. No. ABIN6940822
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Application WB, IF, ELISA, IHC (p)
Validations
  • (6)
Cat. No. ABIN563306
Quantity 100 μg
Datasheet Datasheet

Recommended TYMS ELISA试剂盒

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6959948
Quantity 96 tests
Datasheet Datasheet
Reactivity Mouse
Analytical Method
Validations
Cat. No. ABIN1161751
Quantity 96 tests
Datasheet Datasheet
Reactivity Rat
Analytical Method
Validations
Cat. No. ABIN1161752
Quantity 96 tests
Datasheet Datasheet

Recommended TYMS 蛋白

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
  • (1)
Cat. No. ABIN666924
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1324257
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1324259
Quantity 10 μg
Datasheet Datasheet

Latest Publications for our TYMS Products

Zhao, Zhang, Sun, Zhan, Zhao: "Raltitrexed Inhibits HepG2 Cell Proliferation via G0/G1 Cell Cycle Arrest." in: Oncology research, Vol. 23, Issue 5, pp. 237-48, (2016) (PubMed).

Genovese, Gualandi, Taddia, Marverti, Pirondi, Marraccini, Perco, Pelà, Guerrini, Amoroso, Esposito, Martello, Ponterini, DArca, Costi: "Mass spectrometric/bioinformatic identification of a protein subset that characterizes the cellular activity of anticancer peptides." in: Journal of proteome research, Vol. 13, Issue 11, pp. 5250-61, (2014) (PubMed).

Conradi, Bleckmann, Schirmer, Sprenger, Jo, Homayounfar, Wolff, Rothe, Middel, Becker, Ghadimi, Beissbarth, Liersch: "Thymidylate synthase as a prognostic biomarker for locally advanced rectal cancer after multimodal treatment." in: Annals of surgical oncology, Vol. 18, Issue 9, pp. 2442-52, (2012) (PubMed).

Ma, He, Zhang, Fei, Niu, Wang, Ding, Xu, Chen, Zhu: "DNA methylation-regulated miR-193a-3p dictates resistance of hepatocellular carcinoma to 5-fluorouracil via repression of SRSF2 expression." in: The Journal of biological chemistry, Vol. 287, Issue 8, pp. 5639-49, (2012) (PubMed).

Ren, Kim, Koh, Chang, Eom, Yi, Seong, Kim, Bronner, Cho: "Comparative analysis of thymidylate synthase at the protein, mRNA, and DNA levels as prognostic markers in colorectal adenocarcinoma." in: Journal of surgical oncology, Vol. 100, Issue 7, pp. 546-52, (2009) (PubMed).

Sohn, Croxford, Yates, Lucock, Kim: "Effect of the methylenetetrahydrofolate reductase C677T polymorphism on chemosensitivity of colon and breast cancer cells to 5-fluorouracil and methotrexate." in: Journal of the National Cancer Institute, Vol. 96, Issue 2, pp. 134-44, (2004) (PubMed).

Glaser, Staver, Waring, Stender, Ulrich, Davidsen: "Gene expression profiling of multiple histone deacetylase (HDAC) inhibitors: defining a common gene set produced by HDAC inhibition in T24 and MDA carcinoma cell lines." in: Molecular cancer therapeutics, Vol. 2, Issue 2, pp. 151-63, (2003) (PubMed).

Haqqani, Cowling, Maroun, Birnboim: "Characterization of a polyclonal antibody to human thymidylate synthase suitable for the study of colorectal cancer specimens." in: The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society, Vol. 47, Issue 12, pp. 1563-74, (1999) (PubMed).

Schiffer, Clifton, Davisson, Santi, Stroud: "Crystal structure of human thymidylate synthase: a structural mechanism for guiding substrates into the active site." in: Biochemistry, Vol. 34, Issue 50, pp. 16279-87, (1996) (PubMed).

Synonyms and alternative names related to TYMS

thymidylate synthetase (TYMS), thymidylate synthetase (thyA), contains intron in T4 phage (td), thymidylate synthetase (td), ThyE (thyE), thymidylate synthase (DDA3937_RS04960), thymidylate synthetase L homeolog (tyms.L), thymidylate synthase (XBJ1_RS15770), thymidylate synthase (EAMY_RS20680), thymidylate synthase (Tyms), thymidylate synthetase (Tyms), ECK2823, FN1, HST422, JW2795, TMS, ts, Ts, TS

Protein level used designations for TYMS

  • fibronectin 1
  • thymidylate synthase
  • thymidylate synthetase
  • thymidylate synthase-like
  • Tsase
  • TSase
  • TS
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