TRIM5 抗体
(Tripartite Motif Containing 5 (TRIM5))
The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein forms homo-oligomers via the coilel-coil region and localizes to cytoplasmic bodies. It appears to function as a E3 ubiquitin-ligase and ubiqutinates itself to regulate its subcellular localization. It may play a role in retroviral restriction. Multiple alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Dec 2009].
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Latest Publications for our TRIM5 抗体
: "Stabilized human TRIM5α protects human T cells from HIV-1 infection." in: Molecular therapy : the journal of the American Society of Gene Therapy, Vol. 22, Issue 6, pp. 1084-95, (2014) (PubMed).: "Type I interferon responses in rhesus macaques prevent SIV infection and slow disease progression. ..." in: Nature, Vol. 511, Issue 7511, pp. 601-5, (2014) (PubMed).
: "Determinants of the higher order association of the restriction factor TRIM5alpha and other tripartite motif (TRIM) proteins." in: The Journal of biological chemistry, Vol. 286, Issue 32, pp. 27959-70, (2011) (PubMed).
: "Restriction of foamy viruses by primate Trim5alpha." in: Journal of virology, Vol. 82, Issue 11, pp. 5429-39, (2008) (PubMed).
: "The design of artificial retroviral restriction factors." in: Virology, Vol. 365, Issue 2, pp. 302-14, (2007) (PubMed).
: "All three variable regions of the TRIM5alpha B30.2 domain can contribute to the specificity of retrovirus restriction." in: Journal of virology, Vol. 80, Issue 17, pp. 8554-65, (2006) (PubMed).
: "Retrovirus restriction by TRIM5alpha variants from Old World and New World primates." in: Journal of virology, Vol. 79, Issue 7, pp. 3930-7, (2005) (PubMed).
: "Cyclophilin A is required for TRIM5{alpha}-mediated resistance to HIV-1 in Old World monkey cells." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 102, Issue 41, pp. 14849-53, (2005) (PubMed).
: "The human and African green monkey TRIM5alpha genes encode Ref1 and Lv1 retroviral restriction factor activities." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 101, Issue 29, pp. 10780-5, (2004) (PubMed).
: "The cytoplasmic body component TRIM5alpha restricts HIV-1 infection in Old World monkeys." in: Nature, Vol. 427, Issue 6977, pp. 848-53, (2004) (PubMed).
Aliases for TRIM5 抗体
tripartite motif containing 5 (TRIM5) 抗体tripartite motif-containing 5 (Trim5) 抗体
EG667823 抗体
Gm8833 抗体
RGD1304579 抗体
RNF88 抗体
TRIM5 抗体
TRIM5alpha 抗体
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