TRAF2 产品
(TNF Receptor-Associated Factor 2 (TRAF2))
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The protein encoded by this gene is a member of the TNF receptor associated factor (TRAF) protein family. TRAF proteins associate with, and mediate the signal transduction from members of the TNF receptor superfamily. This protein directly interacts with TNF receptors, and forms a heterodimeric complex with TRAF1. This protein is required for TNF-alpha-mediated activation of MAPK8/JNK and NF-kappaB. The protein complex formed by this protein and TRAF1 interacts with the inhibitor-of-apoptosis proteins (IAPs), and functions as a mediator of the anti-apoptotic signals from TNF receptors. The interaction of this protein with TRADD, a TNF receptor associated apoptotic signal transducer, ensures the recruitment of IAPs for the direct inhibition of caspase activation. BIRC2/c-IAP1, an apoptosis inhibitor possessing ubiquitin ligase activity, can unbiquitinate and induce the degradation of this protein, and thus potentiate TNF-induced apoptosis. Multiple alternatively spliced transcript variants have been found for this gene, but the biological validity of only one transcript has been determined. [provided by RefSeq, Jul 2008].
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Featured TRAF2 Categories
Recommended TRAF2 抗体
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, IHC, IP
Validations
- (1)
- (8)
Cat. No.
ABIN3021165
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Mouse
Application
WB, IHC, IP, ICC
Validations
- (6)
Cat. No.
ABIN7443455
Quantity
100 μL
Datasheet
Datasheet
Reactivity
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Application
WB, ELISA, IHC, IF, FACS
Validations
- (8)
Cat. No.
ABIN190911
Quantity
100 μg
Datasheet
Datasheet
Recommended TRAF2 蛋白
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Reactivity
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Datasheet
Reactivity
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Source
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Cat. No.
ABIN7125407
Quantity
50 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1323495
Quantity
10 μg
Datasheet
Datasheet
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Insect Cells
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ABIN3095966
Quantity
1 mg
Datasheet
Datasheet
Latest Publications for our TRAF2 Products
: "Combination of arsenic trioxide and Dasatinib: a new strategy to treat Philadelphia chromosome-positive acute lymphoblastic leukaemia." in: Journal of cellular and molecular medicine, Vol. 22, Issue 3, pp. 1614-1626, (2018) (PubMed).: "MicroRNA-17 Suppresses TNF-α Signaling by Interfering with TRAF2 and cIAP2 Association in Rheumatoid Arthritis Synovial Fibroblasts." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 197, Issue 6, pp. 2219-28, (2017) (PubMed).
: "The MEKK1 PHD ubiquitinates TAB1 to activate MAPKs in response to cytokines." in: The EMBO journal, Vol. 33, Issue 21, pp. 2581-96, (2014) (PubMed).
: "Downregulation of TRAF2 mediates NIK-induced pancreatic cancer cell proliferation and tumorigenicity." in: PLoS ONE, Vol. 8, Issue 1, pp. e53676, (2013) (PubMed).
: "Gsdma3 is a new factor needed for TNF-?-mediated apoptosis signal pathway in mouse skin keratinocytes." in: Histochemistry and cell biology, Vol. 138, Issue 3, pp. 385-96, (2012) (PubMed).
: "A novel dual signaling axis for NSP 5a3a induced apoptosis in head and neck carcinoma." in: Oncotarget, Vol. 2, Issue 12, pp. 1055-74, (2012) (PubMed).
: "A water-soluble parthenolide analogue suppresses in vivo prostate cancer growth by targeting NFkappaB and generating reactive oxygen species." in: The Prostate, Vol. 70, Issue 10, pp. 1074-86, (2010) (PubMed).
: "Expression of TNF-receptor associated factor 2 correlates with poor progression-free survival time in ABC-like primary nodal diffuse large B-cell lymphomas." in: Histopathology, Vol. 52, Issue 5, pp. 578-84, (2008) (PubMed).
: "Effect of inositol hexakisphosphate kinase 2 on transforming growth factor beta-activated kinase 1 and NF-kappaB activation." in: The Journal of biological chemistry, Vol. 282, Issue 21, pp. 15349-56, (2007) (PubMed).
: "TRAF2 and p38 are involved in B cells CD40-mediated APE/Ref-1 nuclear translocation: a novel pathway in B cell activation." in: Molecular immunology, Vol. 45, Issue 1, pp. 76-86, (2007) (PubMed).
Synonyms and alternative names related to TRAF2
TNF-receptor-associated factor 2 (LOC661716), conjugal transfer protein TraF (traF2), TNF receptor associated factor 2 (TRAF2), TNF receptor-associated factor 2 (Traf2), Tnf receptor-associated factor 2 (Traf2), AI325259, MGC:45012, TANK, TRAP, TRAP3Protein level used designations for TRAF2
- GLEAN_07706
- conjugal transfer protein TraF
- E3 ubiquitin-protein ligase TRAF2
- tumor necrosis factor type 2 receptor associated protein 3
- tumor necrosis factor type 2 receptor-associated protein 3
- TRAF family member-associated NFKB activator
- TNF receptor-associated factor 2
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