蛋白简介

This gene is a member of the Src family of protein tyrosine kinases (PTKs). The encoded protein contains N-terminal sites for myristylation and palmitylation, a PTK domain, and SH2 and SH3 domains which are involved in mediating protein-protein interactions with phosphotyrosine-containing and proline-rich motifs, respectively. The protein localizes to plasma membrane ruffles, and functions as a negative regulator of cell migration and adhesion triggered by the beta-2 integrin signal transduction pathway. Infection with Epstein-Barr virus results in the overexpression of this gene. Multiple alternatively spliced variants, encoding the same protein, have been identified.

Alternative names and synonyms associated with Gardner-Rasheed Feline Sarcoma Viral (V-Fgr) Oncogene Homolog (FGR)

• FGR proto-oncogene, Src family tyrosine kinase (FGR) 抗体
• FGR proto-oncogene, Src family tyrosine kinase (Fgr) 抗体

• c-fgr 抗体
• c-src2 抗体
• p55-Fgr 抗体
• p55c-fgr 抗体
• p58-Fgr 抗体
• 显示所有的同义词和别名
• p58c-fgr 抗体
• SRC2 抗体

Protein level used designations for FGR

Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog , c-fgr protooncogene , c-src-2 proto-oncogene , p55-c-fgr protein , proto-oncogene c-Fgr , proto-oncogene tyrosine-protein kinase FGR , tyrosine-protein kinase Fgr , v-fgr feline Gardner-Rasheed sarcoma viral oncogene homolog , Gardner-Rasheed feline sarcoma viral (Fgr) oncogene homolog , proto-oncogene tyrosine-protein kinase Fgr , tyrosine-protein kinase Fgr-like , p55-Fgr , feline Gardner-Rasheed sarcoma viral oncogene homolog