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Fgr 抗体

FGR 适用: 人, 小鼠 WB, ELISA, IHC 宿主: 小鼠 Monoclonal 6G2 unconjugated
产品编号 ABIN969143
发货至: 中国
  • 抗原 See all Fgr (FGR) 抗体
    Fgr (FGR) (Gardner-Rasheed Feline Sarcoma Viral (V-Fgr) Oncogene Homolog (FGR))
    适用
    • 73
    • 17
    • 10
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    人, 小鼠
    宿主
    • 70
    • 3
    • 3
    小鼠
    克隆类型
    • 74
    • 1
    单克隆
    标记
    • 33
    • 6
    • 6
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    This Fgr antibody is un-conjugated
    应用范围
    • 42
    • 34
    • 22
    • 13
    • 13
    • 10
    • 6
    • 4
    • 3
    • 3
    • 2
    Western Blotting (WB), ELISA, Immunohistochemistry (IHC)
    纯化方法
    purified
    免疫原
    Purified recombinant fragment of human FGR expressed in E. coli.
    克隆位点
    6G2
    亚型
    IgG1
    Top Product
    Discover our top product FGR Primary Antibody
  • 应用备注
    ELISA: 1:10000, WB: 1:500 - 1:2000, IHC: 1:200 - 1:1000
    限制
    仅限研究用
  • 状态
    Liquid
    缓冲液
    Ascitic fluid containing 0.03 % sodium azide.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    4 °C/-20 °C
    储存方法
    4°C, -20°C for long term storage
  • Brian, Jolicoeur, Guerrero, Nunez, Sychev, Hegre, Sætrom, Habib, Drake, Schwertfeger, Freedman: "Unique-region phosphorylation targets LynA for rapid degradation, tuning its expression and signaling in myeloid cells." in: eLife, Vol. 8, (2020) (PubMed).

    Freedman, Tan, Skrzypczynska, Manz, Sjaastad, Goodridge, Lowell, Weiss: "LynA regulates an inflammation-sensitive signaling checkpoint in macrophages." in: eLife, Vol. 4, (2016) (PubMed).

    Heneghan, Connaghan-Jones, Miura, Bain: "Coactivator assembly at the promoter: efficient recruitment of SRC2 is coupled to cooperative DNA binding by the progesterone receptor." in: Biochemistry, Vol. 46, Issue 39, pp. 11023-32, (2007) (PubMed).

    Zhang, Meng, Chu, Takai, Lowell: "The Src family kinases Hck and Fgr negatively regulate neutrophil and dendritic cell chemokine signaling via PIR-B." in: Immunity, Vol. 22, Issue 2, pp. 235-46, (2005) (PubMed).

  • 抗原
    Fgr (FGR) (Gardner-Rasheed Feline Sarcoma Viral (V-Fgr) Oncogene Homolog (FGR))
    别名
    FGR (FGR 产品)
    别名
    SRC2 antibody, c-fgr antibody, c-src2 antibody, p55-Fgr antibody, p55c-fgr antibody, p58-Fgr antibody, p58c-fgr antibody, FGR proto-oncogene, Src family tyrosine kinase antibody, FGR antibody, Fgr antibody
    背景

    Description: FGR: Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog, also known as SRC2, c-fgr, c-src2, FLJ43153, MGC75096, p55c-fgr, p58c-fgr. It is a member of the Src family of protein tyrosine kinases (PTKs). The encoded protein contains N-terminal sites for myristylation and palmitylation, a PTK domain, and SH2 and SH3 domains which are involved in mediating protein-protein interactions with phosphotyrosine-containing and proline-rich motifs, respectively. The protein localizes to plasma membrane ruffles, and functions as a negative regulator of cell migration and adhesion triggered by the beta-2 integrin signal transduction pathway. Infection with Epstein-Barr virus results in the overexpression of this gene. Multiple alternatively spliced variants, encoding the same protein, have been identified.

    Aliases: SRC2, c-fgr, c-src2, p55c-fgr, p58c-fgr

    分子量
    56 kDa
    基因ID
    2268
    HGNC
    2268
    途径
    Sensory Perception of Sound, Stem Cell Maintenance, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, CXCR4-mediated Signaling Events, Thromboxane A2 Receptor Signaling
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