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- 抗原 See all Fgr (FGR) 抗体
- Fgr (FGR) (Gardner-Rasheed Feline Sarcoma Viral (V-Fgr) Oncogene Homolog (FGR))
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抗原表位
- AA 11-72
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适用
- 人
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This Fgr antibody is un-conjugated
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应用范围
- ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)
- 交叉反应
- 人
- 纯化方法
- >95%, Protein G purified
- 免疫原
- Recombinant Human Tyrosine-protein kinase Fgr protein (11-72AA)
- 亚型
- IgG
- Top Product
- Discover our top product FGR Primary Antibody
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anti-Gardner-Rasheed Feline Sarcoma Viral (V-Fgr) Oncogene Homolog (FGR) (AA 1-90) antibody
FGR 适用: 人 WB, ELISA, IHC (p) 宿主: 小鼠 Monoclonal 3G10 unconjugated
anti-Gardner-Rasheed Feline Sarcoma Viral (V-Fgr) Oncogene Homolog (FGR) (AA 3-33), (N-Term) antibodyFGR 适用: 人 WB, IHC (p), IF 宿主: 兔 Polyclonal RB3095 unconjugated
anti-Gardner-Rasheed Feline Sarcoma Viral (V-Fgr) Oncogene Homolog (FGR) antibodyFGR 适用: 人, 小鼠 WB, ELISA, IHC 宿主: 小鼠 Monoclonal 6G2 unconjugated
anti-Gardner-Rasheed Feline Sarcoma Viral (V-Fgr) Oncogene Homolog (FGR) (AA 11-40), (N-Term) antibodyFGR 适用: 人 WB, IHC (p), IF, EIA 宿主: 兔 Polyclonal unconjugated
anti-Gardner-Rasheed Feline Sarcoma Viral (V-Fgr) Oncogene Homolog (FGR) (AA 1-529) antibodyFGR 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated
anti-Gardner-Rasheed Feline Sarcoma Viral (V-Fgr) Oncogene Homolog (FGR) (AA 1-529) antibodyFGR 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Gardner-Rasheed Feline Sarcoma Viral (V-Fgr) Oncogene Homolog (FGR) (Internal Region) antibodyFGR 适用: 人, 小鼠, 大鼠 WB, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Gardner-Rasheed Feline Sarcoma Viral (V-Fgr) Oncogene Homolog (FGR) (C-Term) antibodyVerified FGR 适用: 人 WB, ELISA 宿主: 山羊 Polyclonal unconjugated
anti-Gardner-Rasheed Feline Sarcoma Viral (V-Fgr) Oncogene Homolog (FGR) (AA 1-100) antibodyFGR 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Gardner-Rasheed Feline Sarcoma Viral (V-Fgr) Oncogene Homolog (FGR) antibodyFGR 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
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- 应用备注
- Recommended dilution: IHC:1:20-1:200, IF:1:50-1:200,
- 限制
- 仅限研究用
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- 状态
- Liquid
- 缓冲液
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Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4 - 储存液
- ProClin
- 注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C,-80 °C
- 储存方法
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- 抗原
- Fgr (FGR) (Gardner-Rasheed Feline Sarcoma Viral (V-Fgr) Oncogene Homolog (FGR))
- 别名
- FGR (FGR 产品)
- 别名
- SRC2 antibody, c-fgr antibody, c-src2 antibody, p55-Fgr antibody, p55c-fgr antibody, p58-Fgr antibody, p58c-fgr antibody, FGR proto-oncogene, Src family tyrosine kinase antibody, FGR antibody, Fgr antibody
- 背景
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Background: Non-receptor tyrosine-protein kinase that transmits signals from cell surface receptors devoid of kinase activity and contributes to the regulation of immune responses, including neutrophil, monocyte, macrophage and mast cell functions, cytoskeleton remodeling in response to extracellular stimuli, phagocytosis, cell adhesion and migration. Promotes mast cell degranulation, release of inflammatory cytokines and IgE-mediated anaphylaxis. Acts downstream of receptors that bind the Fc region of immunoglobulins, such as MS4A2/FCER1B, FCGR2A and/or FCGR2B. Acts downstream of ITGB1 and ITGB2, and regulates actin cytoskeleton reorganization, cell spreading and adhesion. Depending on the context, activates or inhibits cellular responses. Functions as negative regulator of ITGB2 signaling, phagocytosis and SYK activity in monocytes. Required for normal ITGB1 and ITGB2 signaling, normal cell spreading and adhesion in neutrophils and macrophages. Functions as positive regulator of cell migration and regulates cytoskeleton reorganization via RAC1 activation. Phosphorylates SYK (in vitro) and promotes SYK-dependent activation of AKT1 and MAP kinase signaling. Phosphorylates PLD2 in antigen-stimulated mast cells, leading to PLD2 activation and the production of the signaling molecules lysophosphatidic acid and diacylglycerol. Promotes activation of PIK3R1. Phosphorylates FASLG, and thereby regulates its ubiquitination and subsequent internalization. Phosphorylates ABL1. Promotes phosphorylation of CBL, CTTN, PIK3R1, PTK2/FAK1, PTK2B/PYK2 and VAV2. Phosphorylates HCLS1 that has already been phosphorylated by SYK, but not unphosphorylated HCLS1.
Aliases: c fgr antibody, c fgr protooncogene antibody, c src 2 proto oncogene antibody, c src2 antibody, Fgr antibody, FGR_HUMAN antibody, FLJ43153 antibody, Gardner Rasheed feline sarcoma viral (v fgr) antibody, Gardner Rasheed feline sarcoma viral (v fgr) oncogene homolog antibody, Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog antibody, MGC75096 antibody, p55 c fgr protein antibody, P55 FGR antibody, P55-FGR antibody, p55c fgr antibody, p58-Fgr antibody, p58c fgr antibody, p58c-Fgr antibody, Proto oncogene c Fgr antibody, Proto oncogene tyrosine protein kinase FGR antibody, Proto-oncogene c-Fgr antibody, SRC 2 antibody, SRC2 antibody, Tyrosine protein kinase Fgr antibody, Tyrosine-protein kinase Fgr antibody
- UniProt
- P09769
- 途径
- Sensory Perception of Sound, Stem Cell Maintenance, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, CXCR4-mediated Signaling Events, Thromboxane A2 Receptor Signaling
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