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Fgr 产品

(Gardner-Rasheed Feline Sarcoma Viral (V-Fgr) Oncogene Homolog (FGR))

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This gene is a member of the Src family of protein tyrosine kinases (PTKs). The encoded protein contains N-terminal sites for myristylation and palmitylation, a PTK domain, and SH2 and SH3 domains which are involved in mediating protein-protein interactions with phosphotyrosine-containing and proline-rich motifs, respectively. The protein localizes to plasma membrane ruffles, and functions as a negative regulator of cell migration and adhesion triggered by the beta-2 integrin signal transduction pathway. Infection with Epstein-Barr virus results in the overexpression of this gene. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jul 2008].

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Featured Fgr Categories

Fgr 抗体

High quality antibodies with extensive validation data.

Fgr ELISA试剂盒

Reliable ELISA kits for a wide range of species.

Fgr 蛋白

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended Fgr 抗体

Product
Reactivity
Application
Validations
Cat. No.
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Datasheet
Reactivity Human
Application WB, ELISA, IHC (p)
Validations
  • (6)
Cat. No. ABIN560883
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Application WB, IHC (p), IF
Validations
  • (2)
  • (5)
Cat. No. ABIN392096
Quantity 400 μL
Datasheet Datasheet
Reactivity Human
Application ELISA, IHC, IF
Validations
  • (3)
Cat. No. ABIN7174020
Quantity 100 μg
Datasheet Datasheet

Recommended Fgr ELISA试剂盒

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Reactivity
Analytical Method
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Cat. No.
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Reactivity Human
Analytical Method Semi-Quantitative Sandwich ELISA
Validations
Cat. No. ABIN4886105
Quantity 96 tests
Datasheet Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
Cat. No. ABIN4882882
Quantity 96 tests
Datasheet Datasheet
Reactivity Human
Analytical Method Semi-Quantitative Sandwich ELISA
Validations
Cat. No. ABIN6385940
Quantity 96 tests
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Recommended Fgr 蛋白

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Source Insect cells (Sf9)
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  • (2)
Cat. No. ABIN5569692
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Source Wheat germ
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  • (1)
Cat. No. ABIN1354066
Quantity 10 μg
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Reactivity Human
Source Wheat germ
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Cat. No. ABIN1354064
Quantity 10 μg
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Latest Publications for our Fgr Products

Brian, Jolicoeur, Guerrero, Nunez, Sychev, Hegre, Sætrom, Habib, Drake, Schwertfeger, Freedman: "Unique-region phosphorylation targets LynA for rapid degradation, tuning its expression and signaling in myeloid cells." in: eLife, Vol. 8, (2020) (PubMed).

Dwyer, Mouchemore, Steer, Sunderland, Sampaio, Greenland, Joyce, Pixley: "Src family kinase expression and subcellular localization in macrophages: implications for their role in CSF-1-induced macrophage migration." in: Journal of leukocyte biology, Vol. 100, Issue 1, pp. 163-75, (2016) (PubMed).

Freedman, Tan, Skrzypczynska, Manz, Sjaastad, Goodridge, Lowell, Weiss: "LynA regulates an inflammation-sensitive signaling checkpoint in macrophages." in: eLife, Vol. 4, (2016) (PubMed).

Henderson, Gonzales, Arora, Choudhary, Trent, Von Hoff, Mousses, Azorsa: "High-throughput RNAi screening identifies a role for TNK1 in growth and survival of pancreatic cancer cells." in: Molecular cancer research : MCR, Vol. 9, Issue 6, pp. 724-32, (2011) (PubMed).

Tatarov, Mitchell, Seywright, Leung, Brunton, Edwards: "SRC family kinase activity is up-regulated in hormone-refractory prostate cancer." in: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 15, Issue 10, pp. 3540-9, (2009) (PubMed).

Heneghan, Connaghan-Jones, Miura, Bain: "Coactivator assembly at the promoter: efficient recruitment of SRC2 is coupled to cooperative DNA binding by the progesterone receptor." in: Biochemistry, Vol. 46, Issue 39, pp. 11023-32, (2007) (PubMed).

Zhang, Meng, Chu, Takai, Lowell: "The Src family kinases Hck and Fgr negatively regulate neutrophil and dendritic cell chemokine signaling via PIR-B." in: Immunity, Vol. 22, Issue 2, pp. 235-46, (2005) (PubMed).

Carriero, Franco, Gargiulo, Vocca, Cito, Fontana, Iaccarino, Del Pozzo, Guardiola, Stoppelli: "Inhibition of receptor-dependent urokinase signaling by specific Ser to Glu substitutions." in: Biological chemistry, Vol. 383, Issue 1, pp. 107-13, (2002) (PubMed).

Cordon-Cardo, Richon: "Expression of the retinoblastoma protein is regulated in normal human tissues." in: The American journal of pathology, Vol. 144, Issue 3, pp. 500-10, (1994) (PubMed).

Dunaief, Strober, Guha, Khavari, Alin, Luban, Begemann, Crabtree, Goff: "The retinoblastoma protein and BRG1 form a complex and cooperate to induce cell cycle arrest." in: Cell, Vol. 79, Issue 1, pp. 119-30, (1994) (PubMed).

Synonyms and alternative names related to Fgr

FGR proto-oncogene, Src family tyrosine kinase (FGR), FGR proto-oncogene, Src family tyrosine kinase (Fgr), c-fgr, c-src2, p55-Fgr, p55c-fgr, p58-Fgr, p58c-fgr, SRC2

Protein level used designations for Fgr

  • Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog
  • c-fgr protooncogene
  • c-src-2 proto-oncogene
  • p55-c-fgr protein
  • proto-oncogene c-Fgr
  • proto-oncogene tyrosine-protein kinase FGR
  • tyrosine-protein kinase Fgr
  • v-fgr feline Gardner-Rasheed sarcoma viral oncogene homolog
  • Gardner-Rasheed feline sarcoma viral (Fgr) oncogene homolog
  • proto-oncogene tyrosine-protein kinase Fgr
  • tyrosine-protein kinase Fgr-like
  • p55-Fgr
  • feline Gardner-Rasheed sarcoma viral oncogene homolog
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