FGFR3 产品
(Fibroblast Growth Factor Receptor 3 (FGFR3))
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This gene encodes a member of the fibroblast growth factor receptor (FGFR) family, with its amino acid sequence being highly conserved between members and among divergent species. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member binds acidic and basic fibroblast growth hormone and plays a role in bone development and maintenance. Mutations in this gene lead to craniosynostosis and multiple types of skeletal dysplasia. Three alternatively spliced transcript variants that encode different protein isoforms have been described. [provided by RefSeq, Jul 2009].
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Featured FGFR3 Categories
FGFR3 抗体
High quality antibodies with extensive validation data.
FGFR3 ELISA试剂盒
Reliable ELISA kits for a wide range of species.
FGFR3 蛋白
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended FGFR3 抗体
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Cat. No.
ABIN5542298
Quantity
0.1 mg
Datasheet
Datasheet
Reactivity
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Application
WB, IHC, IP, ICC
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- (5)
Cat. No.
ABIN7434086
Quantity
100 μL
Datasheet
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Reactivity
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Cat. No.
ABIN1679839
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Recommended FGFR3 ELISA试剂盒
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ABIN6955879
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Cat. No.
ABIN6966793
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Datasheet
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Recommended FGFR3 蛋白
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ABIN5570028
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Reactivity
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Cat. No.
ABIN5570027
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Reactivity
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Latest Publications for our FGFR3 Products
: "A comprehensive characterisation of large-scale expanded human bone marrow and umbilical cord mesenchymal stem cells." in: Stem cell research & therapy, Vol. 10, Issue 1, pp. 99, (2019) (PubMed).: "The Neonatal and Adult Human Testis Defined at the Single-Cell Level." in: Cell reports, Vol. 26, Issue 6, pp. 1501-1517.e4, (2019) (PubMed).
: "FGF23 is synthesised locally by renal tubules and activates injury-primed fibroblasts." in: Scientific reports, Vol. 7, Issue 1, pp. 3345, (2018) (PubMed).
: "Stem cell and neurogenic gene-expression profiles link prostate basal cells to aggressive prostate cancer." in: Nature communications, Vol. 7, pp. 10798, (2016) (PubMed).
: "FGFR2 regulates Mre11 expression and double-strand break repair via the MEK-ERK-POU1F1 pathway in breast tumorigenesis." in: Human molecular genetics, Vol. 24, Issue 12, pp. 3506-17, (2015) (PubMed).
: "Biglycan is a novel binding partner of fibroblast growth factor receptor 3c (FGFR3c) in the human testis." in: Molecular and cellular endocrinology, Vol. 399, pp. 235-43, (2014) (PubMed).
: "Selenium induces a multi-targeted cell death process in addition to ROS formation." in: Journal of cellular and molecular medicine, Vol. 18, Issue 4, pp. 671-84, (2014) (PubMed).
: "Phenotype, donor age and gender affect function of human bone marrow-derived mesenchymal stromal cells." in: BMC medicine, Vol. 11, pp. 146, (2013) (PubMed).
: "Identification of autocrine growth factors secreted by CHO cells for applications in single-cell cloning media." in: Journal of proteome research, Vol. 12, Issue 7, pp. 3496-510, (2013) (PubMed).
: "Fibroblast growth factor-2 (Fgf2) is an important factor that maintains cellular immaturity and contributes to aggressiveness of osteosarcoma." in: Molecular cancer research : MCR, (2012) (PubMed).
Synonyms and alternative names related to FGFR3
fibroblast growth factor receptor 3 (FGFR3), fibroblast growth factor receptor 3 (achondroplasia, thanatophoric dwarfism) S homeolog (fgfr3.S), fibroblast growth factor receptor 3 (Fgfr3), fibroblast growth factor receptor 3 (fgfr3), ACH, CD333, CEK2, fc27h01, Fgfr-3, FGFR3, Flg-2, FR3, HBGFR, HSFGFR3EX, JTK4, LOC100034114, Mfr3, sam3, wu:fc27h01Protein level used designations for FGFR3
- fibroblast growth factor receptor 3
- FGFR-3
- fibroblast growth factor receptor 3 variant 4
- hydroxyaryl-protein kinase
- tyrosine kinase JTK4
- heparin-binding growth factor receptor
- fibroblast growth factor receptor 3-IIIc
- tyrosine kinase (cek2)
- tyrosine kinase receptor CEK2
- fibroblast growth factor receptor 3 (achondroplasia, thanatophoric dwarfism)
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