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小鼠 anti-人 IgM (Chain mu) Antibody

WB, IF, IHC (fro), DB, EIA Monoclonal UHB IgG3 unconjugated
产品编号 ABIN371464
发货至: 中国
  • 抗原 See all IgM products
    IgM
    抗原表位
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    Chain mu
    适用
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    宿主
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    • 188
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    小鼠
    克隆类型
    • 496
    • 78
    单克隆
    应用范围
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    Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Frozen Sections) (IHC (fro)), Dot Blot (DB), Enzyme Immunoassay (EIA)
    内毒素水平
    Low Endotoxin
    克隆位点
    UHB
    亚型
    IgG3
  • 应用备注
    Indirect Immunofluorescent staining of IgM+ human B lymphocytes. ELISA. Western blotting. Dot- and Slot-Immunoblotting. Immunohistochemistry on Frozen Sections. Immunocytochemistry.

    Other applications not tested.
    Otimal dilutions are dependent on conditions and should be determined by the user.
    限制
    仅限研究用
  • 浓度
    0.5 mg/mL
    缓冲液
    PBS without preservatives.
    储存液
    Without preservative
    注意事项
    Avoid repeated freezing and thawing.
    储存条件
    -20 °C
    储存方法
    Store the antibody undiluted (in aliquots) at -20 °C.
  • 抗原
    IgM
    Abstract
    IgM 产品
    物质类
    Antibody
    背景
    IgM normally constitutes about 10 % of serum immunoglobulins. IgM antibody is prominent in early immune responses to most antigens and is largely confined to plasma due to it's large size. Monomeric IgM is expressed as a membrane bound antibody on the surface of B cells and as a pentamer when secreted by plasma cells. Due to it's high valency IgM is more efficient than other isotypes is binding antigens with repeating epitopes (virus particles and red blood cells) and is more efficient than IgG in activiating the complement pathway. The gene for the mu constant region contains four domains separated by short intervening sequences. IgM measurement yields information about the body's immediate resistance and response to infection as well as information related to specific diseases. Decreased levels are associated with immune deficiency states, hereditary deficiencies, and myeloma. Increased levels can be associated with Waldenstrom's macroglobulinemia, chronic infection and hepatocellular disease.Synonyms: Human Immunoglobulin M
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