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抗Mouse (Murine) Neuregulin 1 抗体:
抗Human Neuregulin 1 抗体:
抗Rat (Rattus) Neuregulin 1 抗体:
Human Polyclonal Neuregulin 1 Primary Antibody for WB - ABIN516692
Nordqvist, Kårehed, Hambiliki, Wånggren, Stavreus-Evers, Akerud: The presence of histidine-rich glycoprotein in the female reproductive tract and in embryos. in Reproductive sciences (Thousand Oaks, Calif.) 2010
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Human Polyclonal Neuregulin 1 Primary Antibody for FACS, IHC (p) - ABIN390160
Ritch, Carroll, Sontheimer: Neuregulin-1 enhances motility and migration of human astrocytic glioma cells. in The Journal of biological chemistry 2003
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We show here that cleavage-stimuli-induced specific ICD-modifications cause structural substrate changes that enhance ectodomain sensitivity of neuregulin-1 (NRG1; epidermal-growth-factor (显示 EGF 抗体)) or CD44 (显示 CD44 抗体) (receptor-tyrosine-kinase (显示 ERBB3 抗体) (RTK) co-receptor) to chymotrypsin/trypsin or soluble ADAM.
Study found that the expression level of the neuregulin-1 (NRG1) protein was increased in the medial prefrontal cortex of fear-conditioned mice and manipulation of NRG1 activity in the prelimbic cortex affected fear-conditioning behaviors.
The manipulation of NRG1/ErbB4 (显示 ERBB4 抗体) signaling in the present study revealed that NRG1/ErbB4 (显示 ERBB4 抗体) activity in the hippocampus is critical for learning and memory.
Nrg1-I intramuscular injection enhanced muscle reinnervation by collateral sprouting
These results collectively suggest that sustained activation of Wnt (显示 WNT2 抗体)/beta-catenin (显示 CTNNB1 抗体) signaling in endothelial cells might be a cause of heart failure through suppressing neuregulin-ErbB (显示 EGFR 抗体) signaling.
These results suggest that the neuropsin (显示 KLK8 抗体)-NRG1 signaling system has a role in pathological processes underlying temporal lobe epilepsy by regulating the activity of parvalbumin (显示 PVALB 抗体)-expressing interneurons, and that neuropsin (显示 KLK8 抗体) regulates E/I balance and gamma oscillations through NRG1-ErbB4 (显示 ERBB4 抗体) signaling toward parvalbumin (显示 PVALB 抗体)-expressing interneurons.
we show that the antifibrotic effect of neuregulin-1 is at least partially mediated through anti-inflammatory activity, linked to receptor tyrosine-protein kinase erbB-4 (显示 ERBB4 抗体) activation in macrophages
Results show that at ventral hippocampus-nucleus accumbens synapses, presynaptic type III Nrg1 bidirectional signaling controls the establishment of ventral hippocampus-nucleus accumbens glutamatergic synapses. Type III Nrg1 back-signaling contributes to functional synaptic vesicle clustering and neurotransmitter vesicle release.
Results demonstrate for the first time a link between a mutation of a schizophrenia risk gene, neuregulin 1 and altered neuronal resonance properties in sensory cortex.
findings reveal molecular, cellular, and circuit mechanisms of NRG1/ErbB4 (显示 ERBB4 抗体) in regulating the initiation of critical period visual cortical plasticity.
Levels of NRG1 type III expression in peripheral blood mononuclear cells were positively correlated with impairments in social interaction in children with autism spectrum disorder.
NRG1-dependent activation of HER3 (显示 ERBB3 抗体) induces primary resistance to trastuzumab in HER2 (显示 ERBB2 抗体)-overexpressing breast cancer cells. HER3 (显示 ERBB3 抗体) monoclonal antibody combined with trastuzumab may serve as a treatment choice for patients with primary resistance to trastuzumab.
Results represent the first comprehensive investigation of neuregulin-1 (NRG1) isoforms and protein expression in the blood of clozapine-treated schizophrenia patients and suggest levels of some NRG1 transcripts are upregulated in those with schizophrenia.
HRG/HER2 (显示 ERBB2 抗体)/HER3 (显示 ERBB3 抗体) signaling promotes AhR (显示 AHR 抗体)-mediated Memo-1 (显示 MEMO1 抗体) expression and migration in colorectal cancer
Date indicate the subcellular localization and dynamics post-translational processing, (ectodomain shedding) of neuregulin1 (NRG1).
NRG1 and Gal-3 (显示 LGALS3 抗体) were significantly more elevated in cancer patients than in healthy controls.
The toxicity profile of lumretuzumab in combination with cetuximab and erlotinib was manageable, but only modest clinical activity was observed across tumor types. In the sqNSCLC cohort, there was no evidence of meaningful clinical benefit despite enriching for tumors with higher HRG mRNA expression levels.
Using time-resolved-fluorescence energy transfer (TR-FRET), we demonstrated that in the presence of recombinant NRG1, binding of 9F7-F11 (显示 F11 抗体) (a nonligand-competing anti-HER3 (显示 ERBB3 抗体) antibody) to HER3 (显示 ERBB3 抗体) is increased, whereas that of ligand-competing anti-HER3 (显示 ERBB3 抗体) antibodies is decreased.
Data suggest that SLC3A2 (显示 SLC3A2 抗体)-NRG1 should be considered a therapeutic target for patients with invasive mucinous adenocarcinoma of the lung (IMA).
we show that ErbB3 (显示 ERBB3 抗体) interacts with the ESCRT-0 subunit Hrs both in the presence and absence of heregulin. This indicates an ESCRT-mediated sorting of ErbB3 (显示 ERBB3 抗体) to late endosomes and lysosomes, and in line with this we show that impaired ESCRT function leads to an endosomal accumulation of ErbB3 (显示 ERBB3 抗体).
Data suggest that epidermal growth factor receptor (显示 EGFR 抗体) B [ErbB (显示 EGFR 抗体)] isoforms and their ligands (epidermal growth factor (显示 EGF 抗体) [EGF (显示 EGF 抗体)], amphiregulin (显示 AREG 抗体) [AREG (显示 AREG 抗体)], and neuregulin-1 [NRG1]) are expressed in uteroplacental tissues in mid- and late-phases of pregnancy.
Cloning of a novel isoform of NRG1 (IgNRG1beta2) containing an immunoglobulin-like domain which is probably essential for efficient interaction with ErbB (显示 EGFR 抗体) receptors.
The present research focused on morphological distribution of Nrg1 and its receptors, ErbB2 (显示 ERBB2 抗体) and ErbB4 (显示 ERBB4 抗体), in main gastrointestinal tissues of the non-human primate rhesus monkey.
we observed the activation of Notch (显示 NOTCH1 抗体) signaling in cardiomyocytes adjacent to those undergoing apical constriction, and we showed that this activation is positively regulated by Neuregulin signaling.
these results suggest that Nrg1 is not the primary effector of trabeculation and/or that other EGF (显示 EGF 抗体)-like ligand(s) activates the ErbB2 (显示 ERBB2 抗体)/ErbB4 (显示 ERBB4 抗体) pathway, either through functioning as the primary ligand or acting in a redundant manner. Overall, our work provides an example of cross-species differences in EGF (显示 EGF 抗体) family member requirements for an evolutionary conserved process.
Notch1 (显示 NOTCH1 抗体) activation induces expression of ephrin b2a (efnb2a (显示 EFNB2 抗体)) and neuregulin 1 (nrg1) in the endocardium to promote trabeculation and forced Notch (显示 NOTCH1 抗体) activation in the absence of cardiac contraction rescues efnb2a (显示 EFNB2 抗体) and nrg1 expression
These findings identify Nrg1 as a potent, induced mitogen for the endogenous adult heart regeneration program.
These results demonstrate that Nrg1 type III is an essential signal that controls Schwann cell migration to ensure that these glia are present in the correct numbers and positions in developing nerves.
ErbB3 (显示 ERBB3 抗体) signaling is required for normal migration of trunk, but not cranial, neural crest cells
Disc1 (显示 DISC1 抗体) and nrg1 function in controlling development of oligodendrocytes and neurones from olig2 (显示 OLIG2 抗体)-expressing precursor cells.
NRG1 and PI3K functionally interact with ErbB2 (显示 ERBB2 抗体) and ErbB3 (显示 ERBB3 抗体) during regeneration
The protein encoded by this gene was originally identified as a 44-kD glycoprotein that interacts with the NEU/ERBB2 receptor tyrosine kinase to increase its phosphorylation on tyrosine residues. This protein is a signaling protein that mediates cell-cell interactions and plays critical roles in the growth and development of multiple organ systems. It is known that an extraordinary variety of different isoforms are produced from this gene through alternative promoter usage and splicing. These isoforms are tissue-specifically expressed and differ significantly in their structure, and thereby these isoforms are classified into types I, II, III, IV, V and VI. The gene dysregulation has been linked to diseases such as cancer, schizophrenia and bipolar disorder (BPD).
, pro-neuregulin-1, membrane-bound isoform
, type I neuregulin 1
, type III neuregulin 1
, neuregulin 1
, glial growth factor
, heregulin, alpha (45kD, ERBB2 p185-activator)
, neu differentiation factor
, neuregulin 1 type IV beta 1a
, neuregulin 1 type IV beta 3
, sensory and motor neuron derived factor
, neuregulin 1 type III beta 3
, membrane-bound isoform
, neuregulin 1 alpha isoform