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Human GEMIN5 Protein expressed in HEK-293 Cells - ABIN2721790
Francisco-Velilla, Fernandez-Chamorro, Ramajo, Martinez-Salas: The RNA-binding protein Gemin5 binds directly to the ribosome and regulates global translation. in Nucleic acids research 2016
the WD40 domain (显示 DCAF12L2 蛋白) of Gemin5 is both necessary and sufficient for binding the Sm site of pre-snRNAs
provide mechanistic understandings of Gemin5's snRNA-binding specificity as well as valuable insights into the molecular mechanism of RNA binding by WD40 (显示 DCAF12L2 蛋白) repeat proteins in general.
These results reveal the ribosome-binding capacity of the N-ter (显示 TECR 蛋白) moiety, enabling Gemin5 to control global protein synthesis.
Gemin5 is dispensable for snRNA identification and snRNP (显示 LSM2 蛋白) assembly.
This work both reveals a new autoregulatory pathway governing SMN (显示 STMN1 蛋白) expression, and identifies a new mechanism through which SMN (显示 STMN1 蛋白) can modulate specific mRNA expression via Gemin5.
The C-terminal region of Gemin5 bears two non-canonical bipartite RNA-binding sites.
The Gemin5's function in delivering pre-snRNAs as substrates for Sm core assembly and processing.
gemin5 has a role as a novel cap-binding protein (显示 EIF4E 蛋白) and WD repeat domains are involved in m(7)G recognition
we report the identification of an additional component of the SMN (显示 STMN1 蛋白) complex, a novel WD repeat protein termed Gemin5. Gemin5 binds SMN (显示 STMN1 蛋白) directly and is a component of the SMN (显示 STMN1 蛋白) complex
Gemin5 is the snRNA binding protein of the SMN (显示 STMN1 蛋白) complex, binding directly and specifically to the unique features of snRNAs and is the factor that allows the SMN (显示 STMN1 蛋白) complex to distinguish snRNAs from other cellular RNAs for snRNP (显示 LSM2 蛋白) biogenesis
This gene encodes a WD repeat protein that is a component of the survival of motor neurons (SMN) complex. The SMN complex plays a critical role in mRNA splicing through the assembly of spliceosomal small nuclear ribonucleoproteins (snRNPs), and may also mediate the assembly and transport of other classes of ribonucleoproteins. The encoded protein is the snRNA-binding component of the SMN complex. Dysregulation of this gene may play a role in alternative mRNA splicing and tumor cell motility. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
gem-associated protein 5