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SH2D1A 抗体

(SH2 Domain Containing 1A (SH2D1A))
This gene encodes a protein that plays a major role in the bidirectional stimulation of T and B cells. This protein contains an SH2 domain and a short tail. It associates with the signaling lymphocyte-activation molecule, thereby acting as an inhibitor of this transmembrane protein by blocking the recruitment of the SH2-domain-containing signal-transduction molecule SHP-2 to its docking site. This protein can also bind to other related surface molecules that are expressed on activated T, B and NK cells, thereby modifying signal transduction pathways in these cells. Mutations in this gene cause lymphoproliferative syndrome X-linked type 1 or Duncan disease, a rare immunodeficiency characterized by extreme susceptibility to infection with Epstein-Barr virus, with symptoms including severe mononucleosis and malignant lymphoma. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
SH2D1A 抗体  (AA 1-128) SH2D1A 抗体  (AA 1-128) SH2D1A 抗体 (AA 1-128) (ABIN561703)

SH2D1A 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 1C9 unconjugated

SH2D1A 抗体  (AA 1-128) SH2D1A 抗体  (AA 1-128) SH2D1A 抗体 (AA 1-128) (ABIN3021536)

SH2D1A 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated

SH2D1A 抗体  (AA 11-124) SH2D1A 抗体  (AA 11-124) SH2D1A 抗体 (AA 11-124) (ABIN7169449)

SH2D1A 适用: 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated

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Popular SH2D1A 抗体

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application WB, ELISA
Validations
  • (5)
  • (4)
Cat. No. ABIN561703
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Application WB, IF
Validations
  • (4)
Cat. No. ABIN3021536
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application ELISA, IHC, IF
Validations
  • (2)
Cat. No. ABIN7169449
Quantity 100 μg
Datasheet Datasheet
Reactivity Bat, Human, Monkey, Rabbit
Application WB, IHC, IHC (p)
Validations
  • (2)
Cat. No. ABIN6754909
Quantity 100 μL
Datasheet Datasheet
Reactivity Mouse
Application WB, IHC, ICC
Validations
  • (3)
Cat. No. ABIN1860543
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB
Validations
  • (1)
Cat. No. ABIN517590
Quantity 50 μg
Datasheet Datasheet
Reactivity Human
Application WB, ELISA, IP
Validations
  • (1)
Cat. No. ABIN185426
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Application WB, IP
Validations
  • (1)
Cat. No. ABIN1502673
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Application WB
Validations
  • (5)
  • (1)
Cat. No. ABIN1881802
Quantity 400 μL
Datasheet Datasheet
Reactivity Cow, Horse, Human, Pig, Rat
Application WB
Validations
  • (2)
Cat. No. ABIN2788421
Quantity 100 μL
Datasheet Datasheet
Reactivity Human, Mouse, Rat
Application WB, IF (p), IHC (p)
Validations
Cat. No. ABIN1387212
Quantity 100 μL
Datasheet Datasheet
Reactivity Human, Mouse, Rat
Application WB, IHC (p)
Validations
Cat. No. ABIN1405165
Quantity 100 μL
Datasheet Datasheet
Reactivity Human, Mouse, Rat
Application WB, IF (p)
Validations
Cat. No. ABIN1405163
Quantity 100 μL
Datasheet Datasheet
Reactivity Human, Mouse, Rat
Application WB, IF (p)
Validations
Cat. No. ABIN1405161
Quantity 100 μL
Datasheet Datasheet
Reactivity Human, Mouse, Rat
Application WB, IF (p)
Validations
Cat. No. ABIN1405162
Quantity 100 μL
Datasheet Datasheet

Latest Publications for our SH2D1A 抗体

Menard, Cantaert, Chamberlain, Tangye, Riminton, Church, Klion, Cunningham-Rundles, Nichols, Meffre: "Signaling lymphocytic activation molecule (SLAM)/SLAM-associated protein pathway regulates human B-cell tolerance." in: The Journal of allergy and clinical immunology, Vol. 133, Issue 4, pp. 1149-61, (2014) (PubMed).

Meazza, Tuberosa, Cetica, Falco, Parolini, Grieve, Griffiths, Sieni, Marcenaro, Micalizzi, Montin, Fagioli, Moretta, Mingari, Moretta, Notarangelo, Bottino, Aricò, Pende: "Diagnosing XLP1 in patients with hemophagocytic lymphohistiocytosis." in: The Journal of allergy and clinical immunology, Vol. 134, Issue 6, pp. 1381-1387.e7, (2014) (PubMed).

Palendira, Low, Bell, Ma, Abbott, Phan, Riminton, Choo, Smart, Lougaris, Giliani, Buckley, Grimbacher, Alvaro, Klion, Nichols, Adelstein, Rickinson, Tangye: "Expansion of somatically reverted memory CD8+ T cells in patients with X-linked lymphoproliferative disease caused by selective pressure from Epstein-Barr virus." in: The Journal of experimental medicine, Vol. 209, Issue 5, pp. 913-24, (2012) (PubMed).

Palendira, Low, Chan, Hislop, Ho, Phan, Deenick, Cook, Riminton, Choo, Loh, Alvaro, Booth, Gaspar, Moretta, Khanna, Rickinson, Tangye: "Molecular pathogenesis of EBV susceptibility in XLP as revealed by analysis of female carriers with heterozygous expression of SAP." in: PLoS biology, Vol. 9, Issue 11, pp. e1001187, (2011) (PubMed).

Ma, Suryani, Avery, Chan, Nanan, Santner-Nanan, Deenick, Tangye: "Early commitment of naïve human CD4(+) T cells to the T follicular helper (T(FH)) cell lineage is induced by IL-12." in: Immunology and cell biology, Vol. 87, Issue 8, pp. 590-600, (2009) (PubMed).

Snow, Marsh, Krummey, Roehrs, Young, Zhang, van Hoff, Dhar, Nichols, Filipovich, Su, Bleesing, Lenardo: "Restimulation-induced apoptosis of T cells is impaired in patients with X-linked lymphoproliferative disease caused by SAP deficiency." in: The Journal of clinical investigation, Vol. 119, Issue 10, pp. 2976-89, (2009) (PubMed).

Nagy, Matskova, Kis, Hellman, Klein, Klein: "The proapoptotic function of SAP provides a clue to the clinical picture of X-linked lymphoproliferative disease." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 106, Issue 29, pp. 11966-71, (2009) (PubMed).

Ostrakhovitch, Wang, Li: "SAP binds to CD22 and regulates B cell inhibitory signaling and calcium flux." in: Cellular signalling, Vol. 21, Issue 4, pp. 540-50, (2009) (PubMed).

Ameratunga, Woon: "Customised molecular diagnosis of primary immune deficiency disorders in New Zealand: an efficient strategy for a small developed country." in: The New Zealand medical journal, Vol. 122, Issue 1304, pp. 46-53, (2009) (PubMed).

Schwartzberg, Mueller, Qi, Cannons: "SLAM receptors and SAP influence lymphocyte interactions, development and function." in: Nature reviews. Immunology, Vol. 9, Issue 1, pp. 39-46, (2008) (PubMed).

Aliases for SH2D1A 抗体

SH2 domain containing 1A (SH2D1A) 抗体
SH2 domain containing 1A (Sh2d1a) 抗体
DSHP 抗体
EBVS 抗体
Gm686 抗体
IMD5 抗体
LYP 抗体
MTCP1 抗体
RGD1562408 抗体
SAP 抗体
SAP/SH2D1A 抗体
SH2D1A 抗体
XLP 抗体
XLPD 抗体
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