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In this study, the disordered feature of Nopp140 and the effect of CK2alpha on the structure of Nopp140 were examined using single-molecule fluorescence resonance energy transfer (smFRET) and electron paramagnetic resonance (EPR (显示 EREG 抗体)).
D120 and R195 of H5N1 influenza virus NS1 (显示 PTPN11 抗体) were crucial for the binding to host NOLC1.
pRb2/p130 (显示 RBL2 抗体) cytoplasmic delocalization can lead to cell cycle deregulation
our study demonstrated that DNA methylation (显示 HELLS 抗体) is a key mechanism of silenced NOLC1 expression in human hepatocellular carcinoma cells, and NOLC1 gene hypermethylation of the four CpG dinucleotides is a potential biomarker for hepatocellular carcinoma.
A Nopp140 fragment (residues 568-596) and inositol hexakisphosphate competitively bind to the catalytic subunit of CK2 (显示 CSNK2A1 抗体) (CK2alpha), and phospho-Ser574 of Nopp140 significantly enhances its interaction with CK2alpha.
H5N1 viral NS1 (显示 PTPN11 抗体) interacts with host NOLC1 protein.
NOPP140 is involved in a PKA signaling pathway that leads to agp activation
These data show that Nopp140 reversibly associates with snoRNPs in a phosphorylation-dependent manner, but this association has no effect on pseudouridylation of rRNA.
Hypoxia induces substantial p130 dephosphorylation and nuclear accumulation, leading to the formation of E2F4/p130 complexes and increased occupancy of E2F4 and p130 at the RAD51 and BRCA1 promoters.
hNopp140 serves as a negative regulator of CK2 (显示 CSNK2A1 抗体) and InsP(6) stimulates the activity of CK2 (显示 CSNK2A1 抗体) by blocking the interaction between hNopp140 and CK2 (显示 CSNK2A1 抗体)
Enhanced NOLC1 promotes cell senescence and represses hepatocellular carcinoma cell proliferation by disturbing the organization of nucleolus.
UBF (显示 UBTF 抗体) and Nopp140 dynamic redistribution between the two-cell and blastocyst stages (time of implantation) is correlated with morphological and structural modifications that occur in embryonic nucleolar compartments.
Tcof1 loss-of-function resulted in fish showing phenotypes similar to those observed in TCS patients
interacts with protein phosphatase 1 and actin filaments\; involved in regulation of synaptic transmission
140 kDa nucleolar phosphoprotein
, HCV NS5A trans-regulated protein 13
, HCV NS5A-transactivated protein 13
, hepatitis C virus NS5A-transactivated protein 13
, nucleolar 130 kDa protein
, nucleolar and coiled-body phosphprotein 1
, nucleolar phosphoprotein p130
, nucleolar protein p130
, nucleolar phosphoprotein 140
, nucleolar and coiled-body phosphoprotein 1
, nucleolar phosphoprotein