NOG 抗体
(Noggin (NOG))
The secreted polypeptide, encoded by this gene, binds and inactivates members of the transforming growth factor-beta (TGF-beta) superfamily signaling proteins, such as bone morphogenetic protein-4 (BMP4). By diffusing through extracellular matrices more efficiently than members of the TGF-beta superfamily, this protein may have a principal role in creating morphogenic gradients. The protein appears to have pleiotropic effect, both early in development as well as in later stages. It was originally isolated from Xenopus based on its ability to restore normal dorsal-ventral body axis in embryos that had been artificially ventralized by UV treatment. The results of the mouse knockout of the ortholog suggest that it is involved in numerous developmental processes, such as neural tube fusion and joint formation. Recently, several dominant human NOG mutations in unrelated families with proximal symphalangism (SYM1) and multiple synostoses syndrome (SYNS1) were identified\; both SYM1 and SYNS1 have multiple joint fusion as their principal feature, and map to the same region (17q22) as this gene. All of these mutations altered evolutionarily conserved amino acid residues. The amino acid sequence of this human gene is highly homologous to that of Xenopus, rat and mouse. [provided by RefSeq, Jul 2008].
recommended
NOG 适用: 人, 犬 WB, IHC, IF, IHC (p) 宿主: 小鼠 Monoclonal 4C12 unconjugated
recommended
recommended
NOG 抗体 by 适用
Find NOG 抗体 for a variety of species such as anti-Human NOG, anti-Mouse NOG, anti-Rat NOG. The species listed below are among those available. Click on a link to go to the corresponding products.
NOG 抗体 by 抗体来源
Find NOG 抗体 with a specific 抗体来源. The 抗体来源 listed below are among those available. Click on a link to go to the corresponding products.
NOG 抗体 by 克隆形成能力
Find available monoclonal or polyclonal NOG 抗体. Click on a link to go to the corresponding products.
NOG 抗体 by 克隆
Find NOG 抗体 with a specific 克隆. The 克隆 listed below are among those available. Click on a link to go to the corresponding products.
Popular NOG 抗体
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Reactivity
Application
Validations
Cat. No.
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Datasheet
Reactivity
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Application
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- (6)
Cat. No.
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Quantity
100 μL
Datasheet
Datasheet
Reactivity
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Application
WB, IHC, IP, ICC
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Cat. No.
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Quantity
100 μL
Datasheet
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Cat. No.
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Quantity
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Datasheet
Datasheet
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Application
WB, IP
Validations
- (4)
Cat. No.
ABIN522708
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Mouse, Rat
Application
WB, ELISA, FACS, IF (cc), IF (p), IHC (p), IHC (fro)
Validations
- (1)
- (2)
Cat. No.
ABIN873145
Quantity
100 μL
Datasheet
Datasheet
Reactivity
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Application
IHC, ELISA
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- (2)
Cat. No.
ABIN7161677
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human, Mouse
Application
IHC, ELISA
Validations
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Cat. No.
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Quantity
200 μL
Datasheet
Datasheet
Reactivity
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Application
IHC, ELISA
Validations
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Cat. No.
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Quantity
100 μg
Datasheet
Datasheet
Reactivity
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Cat. No.
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Quantity
200 μL
Datasheet
Datasheet
Reactivity
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Application
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Cat. No.
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Quantity
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Datasheet
Datasheet
Reactivity
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Application
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Validations
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Cat. No.
ABIN522711
Quantity
100 μg
Datasheet
Datasheet
Reactivity
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Application
WB, ELISA
Validations
- (1)
Cat. No.
ABIN522714
Quantity
100 μg
Datasheet
Datasheet
Reactivity
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Application
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Validations
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Cat. No.
ABIN522710
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human, Rat
Application
WB, ELISA, ICC, IF
Validations
- (1)
Cat. No.
ABIN6263681
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Mouse
Application
WB, IHC, ICC
Validations
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Cat. No.
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Quantity
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Datasheet
Datasheet
Latest Publications for our NOG 抗体
: "Expression characteristics of BMP2, BMPR-IA and Noggin in different stages of hair follicle in yak skin." in: General and comparative endocrinology, Vol. 260, pp. 18-24, (2017) (PubMed).: "The bone morphogenetic protein antagonist noggin regulates mammalian cardiac morphogenesis." in: Circulation research, Vol. 100, Issue 2, pp. 220-8, (2007) (PubMed).
: "Lack of noggin expression by cancer cells is a determinant of the osteoblast response in bone metastases." in: The American journal of pathology, Vol. 170, Issue 1, pp. 160-75, (2007) (PubMed).
: "Structural basis of BMP signalling inhibition by the cystine knot protein Noggin." in: Nature, Vol. 420, Issue 6916, pp. 636-42, (2002) (PubMed).
: "The organizer factors Chordin and Noggin are required for mouse forebrain development." in: Nature, Vol. 403, Issue 6770, pp. 658-61, (2000) (PubMed).
: "Noggin-mediated antagonism of BMP signaling is required for growth and patterning of the neural tube and somite." in: Genes & development, Vol. 12, Issue 10, pp. 1438-52, (1998) (PubMed).
: "Identification of mammalian noggin and its expression in the adult nervous system." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 15, Issue 9, pp. 6077-84, (1995) (PubMed).
Aliases for NOG 抗体
noggin (NOG) 抗体noggin (Nog) 抗体
noggin L homeolog (nog.L) 抗体
noggin protein (noggin) 抗体
nog-A 抗体
nog1 抗体
noggin 抗体
noggin-1 抗体
SYM1 抗体
SYNS1 抗体
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