Use your antibodies-online credentials, if available.
Results suggested that the RhoA (显示 RHOA 蛋白)/ROCK1 (显示 ROCK1 蛋白) pathway activated by excessive ROS (显示 ROS1 蛋白) is responsible for profilin-1-mediated endothelial damage.
PFN1 could promote autophagy through taking part in Beclin1 (显示 BECN1 蛋白) complex and contribute to bortezomib resistance, which may become a novel molecular target in the therapy of MM.
Loss of PFN1 in tumor cells has been associated with lymph node invasion and metastasis in other tumor types, strengthening the argument that the protein has the potential to be a tumor suppressor in late-stage oral squamous cell carcinoma.
Guttiferone K effectively suppresses the motility and metastasis of hepatocellular carcinoma cells mainly by restoration of aberrantly reduced PFN1 protein expression
Results collectively suggest that PFN1 promotes cell migration and adhesion in bladder cancer models.
These results suggest that although mutant PFN1 aggregation may contribute to neurodegeneration, it does not trigger its onset. Importantly, these experiments establish a progressive disease model that can contribute toward identifying the mechanisms of ALS pathogenesis and the development of therapeutic treatments.
One potential mechanism for C71G-PFN1 to initiate Amyotrophic lateral sclerosis might be the abnormal interaction with membranes as recently established for SOD1 (显示 SOD1 蛋白) mutants.
Expression of PFN1 mutants induces accumulation of TDP-43 (显示 TARDBP 蛋白), and promotes conversion of normal TDP-43 (显示 TARDBP 蛋白) into an abnormal form. These results provide new insight into the mechanisms of TDP-43 (显示 TARDBP 蛋白) proteinopathies and other diseases associated with amyloid-like protein deposition.
We suggest that reduction of PFN-1 expression by elevated levels of PrP(c (显示 PRNP 蛋白)) may contribute to protective effects PrP(c (显示 PRNP 蛋白))-overexpressing SH-SY5Y cells confer against STS (显示 STS 蛋白)-induced apoptosis
this study shows that in pancreatic cancer patients, PFN1 expression is substantially decreased in peripheral CD8 (显示 CD8A 蛋白)(+) T cells
Profilin1 is expressed in osteocytes and regulates cell shape, migration and bone mass.
overexpression of profilin is sufficient to induce cardiomyocyte hypertrophy and sarcomeric remodelling, and silencing of profilin attenuates the hypertrophic response
Pfn1 is a novel target of BMP and suppresses BMP-induced differentiation of osteoblasts at least in part via transcriptional event.
knockdown of either profilin 1 or profilin 2a led to a significant decrease in cell spreading of astrocytes. Moreover, both isoforms proved to be crucial for forskolin-induced astrocytic stellation.
Inactivation of profilin 1 impaired the radial migration of cerebellar granule neurons
Megakaryocyte-specific Profilin1-deficiency alters microtubule stability and causes a Wiskott-Aldrich syndrome-like platelet defect.
Depleting FMNL1 (显示 FMNL1 蛋白), another Formin (显示 FMN1 蛋白) family member, resulted in reduced mDia1 expression, while RhoA (显示 RHOA 蛋白) inhibition did not alter mDia1 expression, which indicated that there was a FMNL1 (显示 FMNL1 蛋白)-mDia1-Profilin1 signaling pathway in mouse oocytes.
association of cortactin (显示 CTTN 蛋白) with Pfn-1 is regulated by c-Abl (显示 ABL1 蛋白)-mediated cortactin (显示 CTTN 蛋白) phosphorylation
In glioblastomas endothelial cell-specific Pfn-1 phosphorylation elevates HIF-1alpha (显示 HIF1A 蛋白) expression leading to vascular abnormalities and tumor progression.
Pfn1 as a key effector of the integrin linked kinase/Rho/ROCK pathway which acts in parallel with integrin beta1/LCK/Rac1 and regulates Schwann cells lamellipodia formation, radial sorting and myelination during peripheral nervous system maturation.
biophysical analysis reveals that the open nucleotide pocket of the profilin/actin x-ray structure is unstable and closes in the absence of profilin
nitric oxide and free radicals produced under different conditions could alter the functions of profilin through nitration, such as its interaction with actin and poly (l-proline).
Profilin regulates actin dynamics both within the cytoplasm and inside the nuclei of developing mammalian embryos.
Phosphorylation studies indicate that profilin dimers are not phosphorylated while teramers are preferentially phosphorylated over monomers.
PRF1 coordinates the stochastic dynamic properties of actin filaments by modulating formin-mediated actin nucleation and assembly during plant cell expansion.
formed a filamentous network likely associated with actin filaments
protein CYK-1 and the profilin PFN-1 mediate the Arp2/3-independent assembly of cortical microfilaments and are required for cytokinesis in the early embryo
Thus the model organism Caenorhabditis elegans expresses three profilin isoforms and is the first invertebrate animal with tissue-specific profilin expression.
profilin promotes actin organisation
This gene encodes a member of the profilin family of small actin-binding proteins. The encoded protein plays an important role in actin dynamics by regulating actin polymerization in response to extracellular signals. Deletion of this gene is associated with Miller-Dieker syndrome, and the encoded protein may also play a role in Huntington disease. Multiple pseudogenes of this gene are located on chromosome 1.
, profilin 1
, epididymis tissue protein Li 184a
, profilin I
, actin binding protein