1110036M19Rik Protein, AI462524 Protein, AI646751 Protein, Maspin Protein, PI-5 Protein, Spi7 Protein, ovalbumin Protein, PI5 Protein, maspin Protein, Pi5 Protein, serine (or cysteine) peptidase inhibitor, clade B, member 5 Protein, serpin family B member 5 Protein, serpin peptidase inhibitor, clade B (ovalbumin), member 5 S homeolog Protein, Serpinb5 Protein, SERPINB5 Protein, serpinb5.S Protein
背景
Maspin (mammary serine protease inhibitor) is a non-inhibitory serpin that is expressed predominantly in normal mammary epithelial cells but at significantly reduced levels or absent in most breast carcinomas. It has the ability to block the growth, invasiveness, and metastatic potential of breast and lung tumors. This anti-tumor activity is achieved, in part, by the ability of Maspin to inhibit angiogenesis and to preferentially promote apoptosis of tumor cells. Alternative Names: Protease inhibitor 5 protein, SerpinB5 protein