IFNB1 Protein (AA 22-187)
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北京 101111
Quick Overview for IFNB1 Protein (AA 22-187) (ABIN8056988)
抗原
See all IFNB1 蛋白蛋白类型
宿主
资源
应用范围
纯度
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产品特性
- AA 22-187
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原理
- Recombinant Human IFN-β Protein(Halo Tag)
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序列
- Met22-Asn187
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过滤
- 0.2 μm filtered
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内毒素水平
- < 1.0 EU/mg of the protein as determined by the LAL method
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Biological Activity Comment
- Not validated for activity
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Interferon, beta 1, Fibroblast (IFNB1) (AA 1-187) protein (GST tag)
IFNB1 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AA, AP
Interferon, beta 1, Fibroblast (IFNB1) (AA 22-187) protein (Fc Tag)IFNB1 宿主: 人 宿主: HEK-293 Cells Recombinant The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining. ScA, IA, ADA, AM
Interferon, beta 1, Fibroblast (IFNB1) (AA 22-182) protein (His tag)IFNB1 宿主: 小鼠 宿主: HEK-293 Cells Recombinant The purity of the protein is greater than 85 % as determined by SDS-PAGE and Coomassie blue staining. ScA, IA, ADA, AM
Interferon, beta 1, Fibroblast (IFNB1) (AA 22-182) protein (His tag)IFNB1 宿主: 小鼠 宿主: 大肠杆菌（E. Coli） Recombinant > 95 % SDS
Interferon, beta 1, Fibroblast (IFNB1) (AA 22-187), (full length) protein (GST tag)IFNB1 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant 90 % ELISA
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis.
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缓冲液
- Lyophilized from a 0.2 μm filtered solution in PBS with 5 % Trehalose and 5 % Mannitol.
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储存条件
- 4 °C,-20 °C,-80 °C
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储存方法
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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有效期
- 12 months
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- IFNB1 (Interferon, beta 1, Fibroblast (IFNB1))
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别名
- IFN-beta
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背景
- Interferon beta,IFNB,Fibroblast interferon,Interferons (IFNs) are natural glycoproteins belonging to the cytokine superfamily and are produced by the cells of the immune system of most vertebrates in response to challenges by foreign agents such as viruses, parasites, and tumor cells. Interferon-beta (IFN beta) is an extracellular protein mediator of host defense and homeostasis. IFN beta has well-established direct antiviral, antiproliferative, and immunomodulatory properties. Recombinant IFN beta is approved for the treatment of relapsing-remitting multiple sclerosis. The recombinant IFN beta protein has the theoretical potential to either treat or causes autoimmune neuromuscular disorders by altering the complicated and delicate balances within the immune system networks. It is the most widely prescribed disease-modifying therapy for multiple sclerosis (MS). Large-scale clinical trials have established the clinical efficacy of IFN beta in reducing relapses and slowing disease progression in relapsing-remitting MS. IFN beta therapy was shown to be comparably beneficial for opticospinal MS (OSMS) and conventional MS in Japanese. IFN beta is effective in reducing relapses in secondary progressive MS and may have a modest effect in slowing disability progression. In addition to the common antiviral activity, IFN beta also induces increased production of the p53 gene product which promotes apoptosis and thus has a therapeutic effect against certain cancers. The role of IFN-beta in bone metabolism could warrant its systematic evaluation as a potential adjunct to therapeutic regimens of osteolytic diseases. Furthermore, IFN beta might play a beneficial role in the development of chronic progressive CNS inflammation.
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分子量
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Calculated MW: 51.1 kDa
Observed MW: 55 kDa
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基因ID
- 3456
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UniProt
- P01574
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途径
- JAK/STAT Signaling, TCR Signaling, TLR signaling, Regulation of Leukocyte Mediated Immunity, Production of Molecular Mediator of Immune Response, Positive Regulation of Endopeptidase Activity, Hepatitis C, Autophagy, Inflammasome
抗原
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