TGFBR1 Protein (Fc Tag,His tag)
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- 抗原 See all TGFBR1 蛋白
- TGFBR1 (Transforming Growth Factor, beta Receptor 1 (TGFBR1))
- 蛋白类型
- Recombinant
- 生物活性
- Active
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宿主
- 人
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资源
- HEK-293 Cells
- 标记
- This TGFBR1 protein is labelled with Fc Tag,His tag.
- 原理
- Active Recombinant Human TGFR-1/ALK-5 Protein
- 序列
- MEAAVAAPRP RLLLLVLAAA AAAAAALLPG ATALQCFCHL CTKDNFTCVT DGLCFVSVTE TTDKVIHNSM CIAEIDLIPR DRPFVCAPSS KTGSVTTTYC CNQDHCNKIE LPTTVKSSPG LGPVE
- 特异性
- Met1-Glu125
- 纯度
- > 95 % by SDS-PAGE.
- 过滤
- 0.22 μm filtered
- 内毒素水平
- <1EU/μg
- Biological Activity Comment
- Measured by its binding ability in a functional ELISA. Immobilized Human TGF-beta Protein at 2 μg/mL (100 μL/well) can bind TGFBR1 with a linear range of 3.9-80.49 ng/mL.
- Top Product
- Discover our top product TGFBR1 蛋白
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Transforming Growth Factor, beta Receptor 1 (TGFBR1) protein (mFc-Avi Tag)
TGFBR1 宿主: 人 宿主: HEK-293 Cells Recombinant > 95% as determined by Tris-Bis PAGE,> 95% as determined by HPLC
Transforming Growth Factor, beta Receptor 1 (TGFBR1) protein (Fc Tag)TGFBR1 宿主: 人 宿主: HEK-293 Cells Recombinant The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining.
Transforming Growth Factor, beta Receptor 1 (TGFBR1) (AA 30-125) protein (GST tag)TGFBR1 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
Transforming Growth Factor, beta Receptor 1 (TGFBR1) (AA 34-125) protein (mFc-Avi Tag,Biotin)TGFBR1 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE
Transforming Growth Factor, beta Receptor 1 (TGFBR1) protein (Fc Tag)TGFBR1 宿主: 小鼠 宿主: 人细胞 Recombinant >95 % as determined by reducing SDS-PAGE.
Transforming Growth Factor, beta Receptor 1 (TGFBR1) (AA 200-503) (Active) protein (GST tag,His tag)TGFBR1 宿主: 人 宿主: Baculovirus infected Insect Cells Recombinant > 95 % as determined by reducing SDS-PAGE. Active
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- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- Centrifuge the vial before opening. Reconstitute to a concentration of 0.1-0.5 mg/mL in sterile distilled water. Avoid votex or vigorously pipetting the protein. For long term storage, it is recommended to add a carrier protein or stablizer (e.g. 0.1 % BSA, 5 % HSA, 10 % FBS or 5 % Trehalose), and aliquot the reconstituted protein solution to minimize free-thaw cycles.
- 缓冲液
- Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4.
- 储存条件
- -20 °C,-80 °C
- 储存方法
- Store the lyophilized protein at -20°C to -80°C for long term.|After reconstitution, the protein solution is stable at -20°C for 3 months, at 2-8°C for up to 1 week.
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- 抗原
- TGFBR1 (Transforming Growth Factor, beta Receptor 1 (TGFBR1))
- 别名
- TGFR-1/ALK-5 (TGFBR1 产品)
- 别名
- AAT5 Protein, ACVRLK4 Protein, ALK-5 Protein, ALK5 Protein, LDS1A Protein, LDS2A Protein, MSSE Protein, SKR4 Protein, TGFR-1 Protein, aat5 Protein, acvrlk4 Protein, alk-5 Protein, alk5 Protein, lds1a Protein, lds2a Protein, skr4 Protein, tgfr-1 Protein, TGFBR1 Protein, x-trr1 Protein, AU017191 Protein, Alk-5 Protein, TbetaR-I Protein, TbetaRI Protein, Alk5 Protein, Skr4 Protein, Tgfr-1 Protein, tbetaR-I Protein, tgfbr1 Protein, zgc:123263 Protein, transforming growth factor beta receptor 1 Protein, transforming growth factor beta receptor I Protein, transforming growth factor beta receptor I S homeolog Protein, transforming growth factor, beta receptor I Protein, transforming growth factor, beta receptor 1 Protein, transforming growth factor, beta receptor 1 a Protein, TGFBR1 Protein, tgfbr1 Protein, tgfbr1.S Protein, Tgfbr1 Protein, tgfbr1a Protein
- 背景
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Description: Transforming growth factor, beta receptor I, also known as Transforming growth factor-beta receptor type I , Serine / threonine-protein kinase receptor R4, Activin receptor-like kinase 5, SKR4, ALK-5, and TGFBR1, is a single-pass type I membrane protein that belongs to the protein kinase superfamily and TGFB receptor subfamily. TGFBR1 / ALK-5 is found in all tissues examined. It is most abundant in placenta and least abundant in brain and heart. TGF-beta functions as a tumor suppressor by inhibiting the cell cycle in the G1 phase. Administration of TGF-beta is able to protect against mammary tumor development in transgenic mouse models in vivo. Disruption of the TGF-beta/SMAD pathway has been implicated in a variety of human cancers, with the majority of colon and gastric cancers being caused by an inactivating mutation of TGF-beta RII. On ligand binding, TGFBR1 / ALK-5 forms a receptor complex consisting of two type I I and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which auto-phosphorylate, then bind and activate SMAD transcriptional regulators.
Name: TGFBR1,AAT5,ACVRLK4,ALK-5,ALK5,ESS1,LDS1,LDS1A,LDS2A,MSSE,SKR4,TGFR-1,tbetaR-I,TBRI,TBR-i
- 基因ID
- 7046
- UniProt
- P36897-1
- 途径
- Growth Factor Binding
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