TGFBR1 Protein (Fc Tag)
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- 抗原 See all TGFBR1 蛋白
- TGFBR1 (Transforming Growth Factor, beta Receptor 1 (TGFBR1))
- 蛋白类型
- Recombinant
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宿主
- 小鼠
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资源
- 人细胞
- 标记
- This TGFBR1 protein is labelled with Fc Tag.
- 原理
- Recombinant Mouse ALK-5/TGFBR1 (C-Fc)
- 序列
- Leu30-Glu125
- 产品特性
- Recombinant Mouse TGF-beta Receptor Type-1 is produced by our Mammalian expression system and the target gene encoding Leu30-Glu125 is expressed with a Fc tag at the C-terminus.
- 纯度
- >95 % as determined by reducing SDS-PAGE.
- 内毒素水平
- < 1.0 EU per μg as determined by the LAL method.
- Top Product
- Discover our top product TGFBR1 蛋白
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Transforming Growth Factor, beta Receptor 1 (TGFBR1) protein (mFc-Avi Tag)
TGFBR1 宿主: 人 宿主: HEK-293 Cells Recombinant > 95% as determined by Tris-Bis PAGE,> 95% as determined by HPLC
Transforming Growth Factor, beta Receptor 1 (TGFBR1) (AA 200-503) (Active) protein (His-GST)TGFBR1 宿主: 人 宿主: Insect cells (Sf9) Recombinant SDS, Func Active
Transforming Growth Factor, beta Receptor 1 (TGFBR1) protein (Fc Tag)TGFBR1 宿主: 人 宿主: HEK-293 Cells Recombinant The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining.
Transforming Growth Factor, beta Receptor 1 (TGFBR1) (AA 30-125) protein (GST tag)TGFBR1 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
Transforming Growth Factor, beta Receptor 1 (TGFBR1) (AA 34-125) protein (mFc-Avi Tag,Biotin)TGFBR1 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE
Transforming Growth Factor, beta Receptor 1 (TGFBR1) (AA 200-503) (Active) protein (GST tag,His tag)TGFBR1 宿主: 人 宿主: Baculovirus infected Insect Cells Recombinant > 95 % as determined by reducing SDS-PAGE. Active
Transforming Growth Factor, beta Receptor 1 (TGFBR1) (AA 148-503) protein (His tag)Crystallography grade TGFBR1 宿主: 人 宿主: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. SDS, WB, ELISA, Crys
Transforming Growth Factor, beta Receptor 1 (TGFBR1) (AA 148-503) protein (His tag)Crystallography grade TGFBR1 宿主: 小鼠 宿主: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. SDS, WB, ELISA, Crys
Transforming Growth Factor, beta Receptor 1 (TGFBR1) (AA 34-503) protein (rho-1D4 tag)Crystallography grade TGFBR1 宿主: 人 宿主: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. SDS, WB, ELISA, Crys
Transforming Growth Factor, beta Receptor 1 (TGFBR1) (AA 30-503) protein (rho-1D4 tag)Crystallography grade TGFBR1 宿主: 小鼠 宿主: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. SDS, WB, ELISA, Crys
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- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- Please refer to the printed manual for detailed information.
- 缓冲液
- Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
- 储存条件
- 4 °C,-20 °C,-80 °C
- 储存方法
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- 抗原
- TGFBR1 (Transforming Growth Factor, beta Receptor 1 (TGFBR1))
- 别名
- ALK-5/TGFBR1 (TGFBR1 产品)
- 别名
- AAT5 Protein, ACVRLK4 Protein, ALK-5 Protein, ALK5 Protein, LDS1A Protein, LDS2A Protein, MSSE Protein, SKR4 Protein, TGFR-1 Protein, aat5 Protein, acvrlk4 Protein, alk-5 Protein, alk5 Protein, lds1a Protein, lds2a Protein, skr4 Protein, tgfr-1 Protein, TGFBR1 Protein, x-trr1 Protein, AU017191 Protein, Alk-5 Protein, TbetaR-I Protein, TbetaRI Protein, Alk5 Protein, Skr4 Protein, Tgfr-1 Protein, tbetaR-I Protein, tgfbr1 Protein, zgc:123263 Protein, transforming growth factor beta receptor 1 Protein, transforming growth factor beta receptor I Protein, transforming growth factor beta receptor I S homeolog Protein, transforming growth factor, beta receptor I Protein, transforming growth factor, beta receptor 1 Protein, transforming growth factor, beta receptor 1 a Protein, TGFBR1 Protein, tgfbr1 Protein, tgfbr1.S Protein, Tgfbr1 Protein, tgfbr1a Protein
- 背景
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Background: TGF-beta RI, also called ALK-5, is an approximately 55 kDa type I transmembrane serine/threonine receptor kinase. In the presence of TGF-beta, TGF-beta RI forms a complex with, and is phosphorylated by, TGF-beta RII. Phosphorylated TGF-beta RI can then transiently bind and phosphorylate Smad2 and Smad3. TGF-beta functions as a tumor suppressor by inhibiting the cell cycle in the G1 phase. Administration of TGF-beta is able to protect against mammary tumor development in transgenic mouse models in vivo. Disruption of the TGF-beta/SMAD pathway has been implicated in a variety of human cancers, with the majority of colon and gastric cancers being caused by an inactivating mutation of TGF-beta RII. TGF-beta RI is likely important during development, since mice deficient for TGF-beta RI die at midgestation with severe defects in vascular development of the yolk sac and placenta, and an absence of circulating red blood cells. Furthermore, TGF-beta RI appears to be involved in proper lymphatic network development.
Synonym: AAT5, activin A receptor type II-like kinase, 53kD, ACVRLK4, ALK-5, ALK-5ALK5, LDS1A, LDS2A, SKR4, tbetaR-I, TGFB1R1, TGF-beta receptor type I, TGFbetaRI, TGFBR1, TGF-bRI, TGFR-1
- 分子量
- 37.6 kDa
- UniProt
- Q64729
- 途径
- Growth Factor Binding
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