TGFBR1 Protein (AA 200-503) (GST tag,His tag)
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- 抗原 See all TGFBR1 蛋白
- TGFBR1 (Transforming Growth Factor, beta Receptor 1 (TGFBR1))
- 蛋白类型
- Recombinant
- 生物活性
- Active
- 产品特性
- AA 200-503
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宿主
- 人
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资源
- Baculovirus infected Insect Cells
- 标记
- This TGFBR1 protein is labelled with GST tag,His tag.
- 原理
- Recombinant Human TGFBR1/ALK-5 Protein (aa 200-503, His & GST Tag)(Active)
- 序列
- Thr 200-Mey503
- 产品特性
- A DNA sequence encoding the human ALK5 (P36897-1) (Thr200-Mey503) was fused with the N-terminal polyhistidine-tagged GST tag at the N-terminus.
- 纯度
- > 95 % as determined by reducing SDS-PAGE.
- 内毒素水平
- < 1.0 EU per μg as determined by the LAL method.
- Biological Activity Comment
- The specific activity was determined to be 40 nmol/min/mg using casein as substrate.
- Top Product
- Discover our top product TGFBR1 蛋白
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Transforming Growth Factor, beta Receptor 1 (TGFBR1) protein (mFc-Avi Tag)
TGFBR1 宿主: 人 宿主: HEK-293 Cells Recombinant > 95% as determined by Tris-Bis PAGE,> 95% as determined by HPLC
Transforming Growth Factor, beta Receptor 1 (TGFBR1) (AA 200-503) (Active) protein (His-GST)TGFBR1 宿主: 人 宿主: Insect cells (Sf9) Recombinant SDS, Func Active
Transforming Growth Factor, beta Receptor 1 (TGFBR1) protein (Fc Tag)TGFBR1 宿主: 人 宿主: HEK-293 Cells Recombinant The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining.
Transforming Growth Factor, beta Receptor 1 (TGFBR1) (AA 30-125) protein (GST tag)TGFBR1 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
Transforming Growth Factor, beta Receptor 1 (TGFBR1) (AA 34-125) protein (mFc-Avi Tag,Biotin)TGFBR1 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE
Transforming Growth Factor, beta Receptor 1 (TGFBR1) protein (Fc Tag)TGFBR1 宿主: 小鼠 宿主: 人细胞 Recombinant >95 % as determined by reducing SDS-PAGE.
Transforming Growth Factor, beta Receptor 1 (TGFBR1) (AA 148-503) protein (His tag)Crystallography grade TGFBR1 宿主: 人 宿主: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. SDS, WB, ELISA, Crys
Transforming Growth Factor, beta Receptor 1 (TGFBR1) (AA 148-503) protein (His tag)Crystallography grade TGFBR1 宿主: 小鼠 宿主: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. SDS, WB, ELISA, Crys
Transforming Growth Factor, beta Receptor 1 (TGFBR1) (AA 34-503) protein (rho-1D4 tag)Crystallography grade TGFBR1 宿主: 人 宿主: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. SDS, WB, ELISA, Crys
Transforming Growth Factor, beta Receptor 1 (TGFBR1) (AA 30-503) protein (rho-1D4 tag)Crystallography grade TGFBR1 宿主: 小鼠 宿主: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. SDS, WB, ELISA, Crys
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- 限制
- 仅限研究用
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- 状态
- Frozen, Liquid
- 缓冲液
- Supplied as sterile 20 mM Tris, 500 mM Nacl, pH 8.5, 10 % glycerol
- 储存条件
- -20 °C
- 储存方法
- Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
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- 抗原
- TGFBR1 (Transforming Growth Factor, beta Receptor 1 (TGFBR1))
- 别名
- TGFBR1/ALK-5 (TGFBR1 产品)
- 别名
- AAT5 Protein, ACVRLK4 Protein, ALK-5 Protein, ALK5 Protein, LDS1A Protein, LDS2A Protein, MSSE Protein, SKR4 Protein, TGFR-1 Protein, aat5 Protein, acvrlk4 Protein, alk-5 Protein, alk5 Protein, lds1a Protein, lds2a Protein, skr4 Protein, tgfr-1 Protein, TGFBR1 Protein, x-trr1 Protein, AU017191 Protein, Alk-5 Protein, TbetaR-I Protein, TbetaRI Protein, Alk5 Protein, Skr4 Protein, Tgfr-1 Protein, tbetaR-I Protein, tgfbr1 Protein, zgc:123263 Protein, transforming growth factor beta receptor 1 Protein, transforming growth factor beta receptor I Protein, transforming growth factor beta receptor I S homeolog Protein, transforming growth factor, beta receptor I Protein, transforming growth factor, beta receptor 1 Protein, transforming growth factor, beta receptor 1 a Protein, TGFBR1 Protein, tgfbr1 Protein, tgfbr1.S Protein, Tgfbr1 Protein, tgfbr1a Protein
- 背景
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Background: Transforming growth factor, beta receptor I, also known as Transforming growth factor-beta receptor type I , Serine / threonine-protein kinase receptor R4, Activin receptor-like kinase 5, SKR4, ALK-5, and TGFBR1, is a single-pass type I membrane protein which belongs to the protein kinase superfamily and TGFB receptor subfamily. TGFBR1 / ALK-5 is found in all tissues examined. It is most abundant in placenta and least abundant in brain and heart. TGF-beta functions as a tumor suppressor by inhibiting the cell cycle in the G1 phase. Administration of TGF-beta is able to protect against mammary tumor development in transgenic mouse models in vivo. Disruption of the TGF-beta/SMAD pathway has been implicated in a variety of human cancers, with the majority of colon and gastric cancers being caused by an inactivating mutation of TGF-beta RII. On ligand binding, TGFBR1 / ALK-5 forms a receptor complex consisting of two type I I and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which auto-phosphorylate, then bind and activate SMAD transcriptional regulators. TGF-beta signaling via TGFBR1 / ALK-5 is not required in myocardial cells during mammalian cardiac development, but plays an irreplaceable cell-autonomous role regulating cellular communication, differentiation and proliferation in endocardial and epicardial cells. Defects in TGFBR1 / ALK-5 are the cause of Loeys-Dietz syndrome type 1A (LDS1A), Loeys-Dietz syndrome type 2A (LDS2A), and aortic aneurysm familial thoracic type 5 (AAT5).
Synonym: AAT5,ACVRLK4,ALK-5,ALK5,ESS1,LDS1,LDS1A,LDS2A,MSSE,SKR4,tbetaR-I,TGFR-1
- 分子量
- 62.6 kDa
- 途径
- Growth Factor Binding
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