TRKB Protein (His tag)
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- 抗原 See all TRKB (NTRK2) 蛋白
- TRKB (NTRK2) (Neurotrophic Tyrosine Kinase, Receptor, Type 2 (NTRK2))
- 蛋白类型
- Recombinant
- 生物活性
- Active
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宿主
- 人
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资源
- HEK-293 Cells
- 标记
- This TRKB protein is labelled with His tag.
- 原理
- Active Recombinant Human Trk-B/NTRK2 Protein
- 序列
- CPTSCKCSAS RIWCSDPSPG IVAFPRLEPN SVDPENITEI FIANQKRLEI INEDDVEAYV GLRNLTIVDS GLKFVAHKAF LKNSNLQHIN FTRNKLTSLS RKHFRHLDLS ELILVGNPFT CSCDIMWIKT LQEAKSSPDT QDLYCLNESS KNIPLANLQI PNCGLPSANL AAPNLTVEEG KSITLSCSVA GDPVPNMYWD VGNLVSKHMN ETSHTQGSLR ITNISSDDSG KQISCVAENL VGEDQDSVNL TVHFAPTITF LESPTSDHHW CIPFTVKGNP KPALQWFYNG AILNESKYIC TKIHVTNHTE YHGCLQLDNP THMNNGDYTL IAKNEYGKDE KQISAHFMGW PGIDDGANPN YPDVIYEDYG TAANDIGDTT NRSNEIPSTD VTDKTGREH
- 特异性
- Cys32-His430
- 纯度
- > 97 % by SDS-PAGE.
- 过滤
- 0.22 μm filtered
- 内毒素水平
- < 1.0 EU/μg of the protein by LAL method.
- Biological Activity Comment
- Measured by its binding ability in a functional ELISA. Immobilized Recombinant HumanTrkB, His Tag at 2 μg/mL (100 μL/well) can bind Recombinant Human BDNF with a linear range of 1.95-258 ng/mL.
- Top Product
- Discover our top product NTRK2 蛋白
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Neurotrophic Tyrosine Kinase, Receptor, Type 2 (NTRK2) (AA 32-430) protein (His tag)
NTRK2 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Neurotrophic Tyrosine Kinase, Receptor, Type 2 (NTRK2) (AA 32-205) protein (His-IF2DI Tag)NTRK2 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 95 % by SDS-PAGE gel analyses ELISA, WB
Neurotrophic Tyrosine Kinase, Receptor, Type 2 (NTRK2) (Active) protein (His tag)NTRK2 宿主: 大鼠 宿主: HEK-293 Cells Recombinant > 95 % as determined by SDS-PAGE Active
Neurotrophic Tyrosine Kinase, Receptor, Type 2 (NTRK2) (AA 41-160) protein (GST tag)NTRK2 宿主: 人 宿主: 小麦胚 Recombinant ELISA, WB, AP, AA
Neurotrophic Tyrosine Kinase, Receptor, Type 2 (NTRK2) (AA 1-477) protein (GST tag)NTRK2 宿主: 人 宿主: 小麦胚 Recombinant ELISA, WB, AP, AA
Neurotrophic Tyrosine Kinase, Receptor, Type 2 (NTRK2) protein (Fc Tag)NTRK2 宿主: 大鼠 宿主: HEK-293 Cells Recombinant > 92 % as determined by SDS-PAGE
Neurotrophic Tyrosine Kinase, Receptor, Type 2 (NTRK2) (Active) protein (His tag)NTRK2 宿主: 小鼠 宿主: HEK-293 Cells Recombinant > 98 % as determined by SDS-PAGE Active
Neurotrophic Tyrosine Kinase, Receptor, Type 2 (NTRK2) protein (His tag)NTRK2 宿主: 小鼠 宿主: 人细胞 Recombinant >95 % as determined by reducing SDS-PAGE.
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- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- Centrifuge the vial before opening. Reconstitute to a concentration of 0.1-0.5 mg/mL in sterile distilled water. Avoid votex or vigorously pipetting the protein. For long term storage, it is recommended to add a carrier protein or stablizer (e.g. 0.1 % BSA, 5 % HSA, 10 % FBS or 5 % Trehalose), and aliquot the reconstituted protein solution to minimize free-thaw cycles.
- 缓冲液
- Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4.
- 储存条件
- -20 °C,-80 °C
- 储存方法
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Store the lyophilized protein at -20°C to -80 °C for long term.
After reconstitution, the protein solution is stable at -20 °C for 3 months, at 2-8 °C for up to 1 week.
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- 抗原
- TRKB (NTRK2) (Neurotrophic Tyrosine Kinase, Receptor, Type 2 (NTRK2))
- 别名
- Trk-B/NTRK2 (NTRK2 产品)
- 别名
- trkb Protein, trkb-b Protein, xtrkb Protein, si:ch211-220b11.1 Protein, trkB2 Protein, NTRK2 Protein, ntrk2 Protein, gp145-trkb Protein, TRKB Protein, GP145-TrkB Protein, trk-B Protein, AI848316 Protein, C030027L06Rik Protein, Tkrb Protein, trkB Protein, RATTRKB1 Protein, TRKB1 Protein, Trk-B Protein, TrkB Protein, neurotrophic receptor tyrosine kinase 2 Protein, neurotrophic receptor tyrosine kinase 2 L homeolog Protein, neurotrophic tyrosine kinase, receptor, type 2b Protein, neurotrophic receptor tyrosine kinase 2 S homeolog Protein, neurotrophic tyrosine kinase, receptor, type 2 Protein, NTRK2 Protein, ntrk2.L Protein, ntrk2b Protein, ntrk2.S Protein, ntrk2 Protein, Ntrk2 Protein
- 背景
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Description: TrkB receptor also known as TrkB tyrosine kinase or BDNF/NT-3 growth factors receptor or neurotrophic tyrosine kinase, receptor, type 2 (NTRK2) is a single transmembrane catalytic receptors with intracellular tyrosine kinase activity. TrkB/NTRK2 is a member of the neurotrophic tyrosine receptor kinase (NTRK) family and contains two Ig-like C2-type (immunoglobulin-like) domains, two LRR (leucine-rich) repeats, one LRRCT domain, one LRRNT domain, one protein kinase domain.TrkB/NTRK2 tyrosine kinase is coupled to the Ras, Cdc42/Rac/RhoG, MAPK, PI3-K and PLCgamma signaling pathways.TrkB/NTRK has high affinity for brain-derived neurotrophic factor (BDNF) and is involved in neuronal plasticity, longterm potentiation and apoptosis of CNS neurons. As a membrane-bound receptor, TrkB/NTRK binds upon neurotrophin, phosphorylates itself and members of the MAPK pathway. NTRK2 / TrkB involved in the development and the maturation of the central and the peripheral nervous systems through regulation of neuron survival, proliferation, migration, differentiation, and synapse formation and plasticity. Mutations in TrkB/NTRK have been associated with obesity and mood disorders.
Name: NTRK2, GP145-TrkB, TRKB, trk-B, BDNF/NT-3 growth factors receptor,GP145-TrkB,TRKB,trk-B,TrkB,OBHD
- 基因ID
- 4915
- UniProt
- Q16620
- 途径
- RTK signaling, Neurotrophin Signaling Pathway, cAMP Metabolic Process, Skeletal Muscle Fiber Development, Feeding Behaviour, Dicarboxylic Acid Transport
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