TRKA Protein (Fc Tag,His tag)
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- 抗原 See all TRKA (NTRK1) 蛋白
- TRKA (NTRK1) (Neurotrophic Tyrosine Kinase, Receptor, Type 1 (NTRK1))
- 蛋白类型
- Recombinant
- 生物活性
- Active
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宿主
- 人
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资源
- HEK-293 Cells
- 标记
- This TRKA protein is labelled with Fc Tag,His tag.
- 原理
- Active Recombinant Human Trk-A/NTRK1 Protein
- 序列
- AAPCPDACCP HGSSGLRCTR DGALDSLHHL PGAENLTELY IENQQHLQHL ELRDLRGLGE LRNLTIVKSG LRFVAPDAFH FTPRLSRLNL SFNALESLSW KTVQGLSLQE LVLSGNPLHC SCALRWLQRW EEEGLGGVPE QKLQCHGQGP LAHMPNASCG VPTLKVQVPN ASVDVGDDVL LRCQVEGRGL EQAGWILTEL EQSATVMKSG GLPSLGLTLA NVTSDLNRKN VTCWAENDVG RAEVSVQVNV SFPASVQLHT AVEMHHWCIP FSVDGQPAPS LRWLFNGSVL NETSFIFTEF LEPAANETVR HGCLRLNQPT HVNNGNYTLL AANPFGQASA SIMAAFMDNP FEFNPEDPIP DTNSTSGDPV EKKDE
- 特异性
- Ala33-Glu407
- 纯度
- > 97 % by SDS-PAGE.
- 过滤
- 0.22 μm filtered
- 内毒素水平
- < 0.1 EU/μg of the protein by LAL method.
- Biological Activity Comment
- Measured by its ability to inhibit NGF-induced proliferation of TF-1 human erythroleukemic cells. The ED50 for this effect is typically 12-48 ng/mL in the presence of 10 ng/mL of recombinant human NGF.
- Top Product
- Discover our top product NTRK1 蛋白
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Neurotrophic Tyrosine Kinase, Receptor, Type 1 (NTRK1) (Active) protein (His tag)
NTRK1 宿主: 小鼠 宿主: HEK-293 Cells Recombinant > 95 % as determined by SDS-PAGE Active
Neurotrophic Tyrosine Kinase, Receptor, Type 1 (NTRK1) (Active) protein (Fc Tag)NTRK1 宿主: 小鼠 宿主: HEK-293 Cells Recombinant > 90 % as determined by SDS-PAGE Active
Neurotrophic Tyrosine Kinase, Receptor, Type 1 (NTRK1) (Active) protein (Fc Tag)NTRK1 宿主: 大鼠 宿主: HEK-293 Cells Recombinant > 95 % as determined by SDS-PAGE Active
Neurotrophic Tyrosine Kinase, Receptor, Type 1 (NTRK1) (Active) protein (His tag)NTRK1 宿主: 大鼠 宿主: HEK-293 Cells Recombinant > 95 % as determined by SDS-PAGE Active
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- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- Centrifuge the vial before opening. Reconstitute to a concentration of 0.1-0.5 mg/mL in sterile distilled water. Avoid votex or vigorously pipetting the protein. For long term storage, it is recommended to add a carrier protein or stablizer (e.g. 0.1 % BSA, 5 % HSA, 10 % FBS or 5 % Trehalose), and aliquot the reconstituted protein solution to minimize free-thaw cycles.
- 缓冲液
- Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4.
- 储存条件
- -20 °C,-80 °C
- 储存方法
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Store the lyophilized protein at -20°C to -80 °C for long term.
After reconstitution, the protein solution is stable at -20 °C for 3 months, at 2-8 °C for up to 1 week.
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- 抗原
- TRKA (NTRK1) (Neurotrophic Tyrosine Kinase, Receptor, Type 1 (NTRK1))
- 别名
- Trk-A/NTRK1 (NTRK1 产品)
- 别名
- MTC Protein, TRK Protein, TRK1 Protein, TRKA Protein, Trk-A Protein, p140-TrkA Protein, CDHF12 Protein, CDHR16 Protein, HSCR1 Protein, MEN2A Protein, MEN2B Protein, MTC1 Protein, PTC Protein, RET-ELE1 Protein, RET51 Protein, Trk Protein, C80751 Protein, Tkr Protein, TrkA Protein, trk Protein, trka Protein, CTRKA Protein, trkA Protein, neurotrophic receptor tyrosine kinase 1 Protein, ret proto-oncogene Protein, neurotrophic tyrosine kinase, receptor, type 1 Protein, NTRK1 Protein, RET Protein, Ntrk1 Protein, ntrk1 Protein
- 背景
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Description: This protein is a member of the neurotrophic tyrosine kinase receptor (NTKR) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. The presence of this kinase leads to cell differentiation and may play a role in specifying sensory neuron subtypes. Mutations in this gene have been associated with congenital insensitivity to pain, anhidrosis, self-mutilating behavior, mental retardation and cancer. Alternate transcriptional splice variants of this gene have been found, but only three have been characterized to date.
Name: MTC, TRK, TRK1, TRKA, Trk-A, p140-TrkA,NTRK1,TRK,TRK1,TRKA,Trk-A,p140-TrkA
- 基因ID
- 4914
- UniProt
- P04629
- 途径
- RTK signaling, Neurotrophin Signaling Pathway, cAMP Metabolic Process
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